A5008774723- Ocular Infections and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Bacterial Identification and Susceptibility Testing
- Ocular Diseases and Behçet’s Syndrome
- Antimicrobial Resistance in Staphylococcus
- Herpesvirus Infections and Treatments
- Bacterial biofilms and quorum sensing
- Legionella and Acanthamoeba research
- Skin Protection and Aging
- Drug-Induced Adverse Reactions
- Acne and Rosacea Treatments and Effects
- Acupuncture Treatment Research Studies
- Retinal and Optic Conditions
- Orthopedic Surgery and Rehabilitation
- Ophthalmology and Eye Disorders
- Congenital Anomalies and Fetal Surgery
- Vibrio bacteria research studies
- Virus-based gene therapy research
- Xenotransplantation and immune response
- Autoimmune Bullous Skin Diseases
University of Pittsburgh
2015-2025
University of Pittsburgh Medical Center
2015-2024
University of Pikeville
2023
Virginia Eye Consultants
2023
Icahn School of Medicine at Mount Sinai
2022
University of Maryland, Baltimore
2015-2022
NYU Langone Health
2022
Eye and Ear Foundation
2003-2019
UPMC Health System
2019
Campbell Foundation
2019
Purpose: To investigate the visual significance of "glistenings" in acrylic intraocular lenses (IOLs). Setting: John Moran Eye Center, University Utah, Salt Lake City. Methods: Seventeen patients who had phacoemulsification with implantation AcrySof® IOL were evaluated by slitlamp examination and acuity, contrast sensitivity, glare testing. Ten a silicone posterior chamber opposite eye testing similar parameters for comparison. Glistenings noted IOLs graded at slitlamp. Laboratory analysis...
Abstract Background Mesenchymal stem cells in the adult corneal stroma (named stromal cells, CSSCs) inhibit inflammation and scarring restore clarity pre-clinical injury models. This cell therapy could alleviate heavy reliance on donor materials for transplantation to treat opacities. Herein, we established Good Manufacturing Practice (GMP) protocols CSSC isolation, propagation, cryostorage, developed vitro quality control (QC) metric vivo anti-scarring potency of CSSCs treating Methods A...
Purpose: To compare the visual outcomes and associated morbidity of patients with Fuchs endothelial corneal dystrophy who were treated either Descemet membrane keratoplasty (DMEK) or descemetorhexis without (DWEK). Methods: This is a retrospective comparative cohort study 27 eyes mild to moderate (with guttae/edema limited central cornea relatively clear periphery) that at University Pittsburgh Medical Center from 2015 2017 DMEK (n = 15) DWEK 12). Descemetorhexis was performed by removing 4...
Purpose: The definitive identification of ocular pathogens optimizes effective treatment. Although the types are known; there is less information on prevalence causative infections including viruses, fungi, and protozoa, which focus this retrospective laboratory review. Methods: Data used for certification were reviewed detection bacteria, from patients with infectious keratitis, endophthalmitis, conjunctivitis. main outcome parameter was laboratory-positive infection. Results: distribution...
Corneal blindness due to scarring is conventionally treated by corneal transplantation, but the shortage of donor materials has been a major issue affecting global success treatment. Pre-clinical and clinical studies have shown that cell-based therapies using either stromal stem cells (CSSC) or keratocytes (CSK) suppress at lower levels. Further treatments strategies are required improve treatment efficacy. This study examined combined CSSC CSK in mouse model anterior injury. We hypothesize...
To compare endophthalmitis rates after cataract extraction in patients with different preoperative prophylaxis: double povidone-iodine preparation topical antibiotics versus a control group. All cases of postoperative over the last 17 years were reviewed. Incidence for all surgeries (current procedural terminology codes 66982 and 66984) performed by 26 surgeons calculated. Cataract surgery combined glaucoma corneal procedures excluded (1,347 surgeries). compared study group (i.e., use...
Abstract: The prevalence of myopia is high and increasing. Approximately 5 billion people around the world are expected to be myopic by year 2050. Methods slow progression therefore potentially decrease associated sight-threatening complications have been subject a number investigations. A workshop, sponsored United States Food Drug Administration (FDA) Center for Devices Radiological Health, American Academy Ophthalmology, Optometry, Association Pediatric Ophthalmology Strabismus,...
We report a case of 20-year-old woman with tear deficiency secondary to Stevens Johnson syndrome who developed bilateral corneal melting following use bromfenac (Xibrom), nonsteroidal antiinflammatory drug (NSAID), for 2 weeks. The patient presented complaints light sensitivity and pain in the right eye. slitlamp examination revealed perforation iris plug eye an 85% thinned cornea left She was admitted hospital, where Xibrom discontinued, therapeutic contact lenses were placed, regimen...
Purpose: Dry eye disease (DED) is a common disorder that negatively impacts quality of life and vision. Prior studies have shown some benefit acupuncture for dry eye, but very few included control group to mitigate placebo effect. This study was designed with sham evaluate true treatment Methods: prospective, randomized, double-blinded, sham-acupuncture-controlled trial. Acupuncture performed as per the Niemtzow Protocol. Twenty-four patients received twenty-five acupuncture. Treatment...
To investigate the cellular effects of mitomycin C (MMC) treatment on corneal endothelial (CE) cells at clinically relevant applications and dosages.Radial posterior diffusion MMC was determined by an Escherichia coli growth inhibition bioassay. A modified version comet assay (single cell gel electrophoresis) used to detect DNA cross-linking. Immunostaining detected nuclear phosphorylated histone variant H2AX (gamma-H2AX) indicating double-strand breaks. Apoptosis in MMC-treated with annexin...
Purpose: Descemet stripping only (DSO) is a relatively novel treatment for Fuchs endothelial corneal dystrophy (FECD). In this procedure, central area of membrane and endothelium removed without the insertion donor tissue. Evaluation long-term outcomes (≥5 years) after DSO imperative to establish validity procedure determine its role in management dystrophy. Published are limited but promising. This study evaluates 5- 6-year patients who had at single institution. Methods: retrospective...