A5071384926- Marine and coastal ecosystems
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Methane Hydrates and Related Phenomena
- Geology and Paleoclimatology Research
- Arctic and Antarctic ice dynamics
- Paleontology and Stratigraphy of Fossils
- Atmospheric and Environmental Gas Dynamics
- Fungal Biology and Applications
- Marine Biology and Ecology Research
- Geochemistry and Elemental Analysis
- Brain Tumor Detection and Classification
- Environmental and Agricultural Sciences
- Geomechanics and Mining Engineering
- Hydrocarbon exploration and reservoir analysis
- Ocean Acidification Effects and Responses
- Stock Market Forecasting Methods
- Oceanographic and Atmospheric Processes
- Polar Research and Ecology
- Phytochemicals and Antioxidant Activities
- Optical Imaging and Spectroscopy Techniques
- Isotope Analysis in Ecology
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
Sun Yat-sen University
2021-2025
Army Medical University
2019-2024
Zhejiang University
2018-2024
Second Institute of Oceanography
2011-2024
Shaanxi Normal University
2012-2024
Ministry of Natural Resources
2000-2024
China Power Engineering Consulting Group (China)
2024
Zhejiang Ocean University
2021-2024
Southern Medical University
2020-2022
Nanfang Hospital
2020-2022
It has been predicted that the Arctic Ocean will sequester much greater amounts of carbon dioxide (CO2) from atmosphere as a result sea ice melt and increasing primary productivity. However, this prediction was made on basis observations either highly productive ocean margins or ice-covered basins before recent major retreat. We report here high-resolution survey sea-surface CO2 concentration across Canada Basin, showing great increase relative to earlier observations. Rapid invasion low...
Peritoneal metastasis predicts poor prognosis of gastric cancer (GC) patients, and the underlying mechanisms are poorly understood.
Phenolic compounds and its antioxidant activity of extracts from seven cultivars Chinese jujubes were investigated by high performance liquid chromatography (HPLC) with standards different evaluation methods, such as phosphomolybdenum assay, superoxide radical scavenging (SRSA), hydroxyl (HRSA), antihemolytic inhibition lipid peroxidation in rat liver homogenate, respectively. The results showed the components are comprised total phenols flavonoids, content ranges 454.3 to 1298.9 (GAE mg/100...
Abstract Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role the progression of cancer. However, expression tDRs colorectal cancer (CRC) plasma their potential diagnostic values have not been systematically explored. Methods The profiles CRC health controls (HCs) investigated by RNA sequencing. level value 5′-tRF-GlyGCC evaluated quantitative PCR samples from 105 patients 90 HCs. mechanisms responsible for...
Studies on biological functions of RNA modifications such as N 6 -methyladenosine (m A) in mRNA have sprung up recent years, while the roles 1 cancer progression remain largely unknown. We find m A demethylase ALKBH3 can regulate glycolysis cells via a demethylation activity dependent manner. Specifically, sequencing and functional studies confirm that ATP5D, one most important subunit adenosine 5′-triphosphate synthase, is involved ALKBH3-regulated cells. The modified A71 at exon ATP5D...
Abstract Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification gene encoding receptor tyrosine kinase epidermal growth factor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal (ESCC), but may become quickly ineffective. Resistance can occur...
Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation. Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) was used to detect changes m6A levels cells. Transmission electron microscopy and flow cytometry were mitochondrial reactive oxygen species (ROS). sequencing (RNA-seq) employed analyze the factors regulating ferroptosis. Chromatin immunoprecipitation (ChIP)...
The antioxidative and anticancer effects of extracted flavonoids from Pink Lady apples on human colon cancer LoVo cells breast MCF-7 were evaluated. It was found that the property peel-flavonoids (Peel-F) more effective than flesh-flavonoids (Flesh-F). Meanwhile, both Peel-F Flesh-F can inhibit cell growth in a dose-dependent manner, with IC50 values 110.33 ± 2.52 mg mL(-1) 378.14 1.64 for 58.42 1.39 296.06 3.71 cells. This led to conclusion against Flesh-F, scavenging ROS significantly...
The excessive production of inflammatory cytokines during invasive infection primarily mediates the pathophysiology sepsis. To improve survival septic patients, many selective or mediator-specific anti-inflammatory agents have been developed. Saikosaponin A (SsA), a triterpenoid saponin isolated from Radix Bupleuri, inhibits proinflammatory mediators in several cell types and protects against CCl4-induced liver injury rats. However, whether SsA treatment provides protective effects sepsis...
Reliable records of Southern Ocean seawater palaeotemperatures are important because this region plays a significant role in regulating global climate change. Biomarkers such as GDGT-based indices have been effectively used to reconstruct temperatures. We analysed the composition and distribution iGDGTs, OH-GDGTs brGDGTs calculated temperature surface sediments from Prydz Bay, East Antarctica. Our results showed that all produced situ, with iGDGTs mostly synthesized by Thaumarchaeota....
Predicting and estimating the response of subway tunnel to adjacent excavation foundation pit is a research focus in field underground engineering. Based on principle two-stage method incremental method, an analytic approach suggested this paper solve problem accurate rapid way, upheavals due are solved by method. Besides, presented used practical engineering case Shenzhen Metro Line 11 verified numerical simulation situ measurement. Finally, parametric analysis performed investigate...
A method of improving the angular random walk (ARW) a fiber optic gyroscope (FOG) using ring resonator (FRR) to reduce relative intensity noise (RIN) is demonstrated. An FRR reduces RIN near proper frequency and improves ARW. The analytical forms for transfer function power transmission are derived when free spectral range much narrower than source bandwidth. Building couplers with low excess loss enhances reduction. For coupling ratios, there trade-off between reduction transmission. ratios...
Focal adhesion kinase (FAK) is a tyrosine with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual inhibition and/or significant activity on several kinases. Although multitargeted at times therapeutically advantageous, such behavior can also lead to toxicity confound chemical-biology studies. We report novel series small molecules...