A5056496279- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Retinal Development and Disorders
- Ubiquitin and proteasome pathways
- Glycogen Storage Diseases and Myoclonus
- Cardiac Arrest and Resuscitation
- Occupational Health and Performance
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Memory and Neural Mechanisms
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
Stony Brook School
2021-2025
Stony Brook University
2021-2025
Stanford University
2024
Abstract The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated perceptual decision-making, transforming stimuli to action outcomes. Despite its known connections diverse neurological conditions, dopaminergic modulation sensory striatal neuronal activity and behavioral influences remain unknown. We demonstrated that optogenetic inhibition projections from substantia nigra pars compacta specifically impairs mouse choice performance but not movement an...
Abstract The auditory striatum, a sensory portion of the dorsal plays an essential role in learning and memory. In contrast to its roles underlying mechanisms operant conditioning, however, little is known about contribution classical fear conditioning. Here, we reveal function striatum auditory-conditioned We find that optogenetically inhibiting striatal neurons impairs memory formation, which mediated through striatal-amygdala pathway. Using calcium imaging behaving mice, neuronal...
Auditory signal-cued behaviors rely on a sophisticated neural network. While extensive research has focused auditory processing and decision-making, the circuits governing motor coordination for goal-directed actions remain poorly understood. The red nucleus (RN) is essential coordination, whereas zona incerta (ZI) plays key role in modulating sensorimotor circuits. Using tetrode recordings optogenetics, we investigated ZI-RN circuit’s an auditory-cued decision task. RN neurons were...
Fanconi–Bickel syndrome (FBS) is a rare metabolic disorder caused by decreased glucose transporter 2 (GLUT2) function due to several known mutations in the SLC2A2 gene. As of 2020, 144 cases FBS have been described literature. Metabolic and somatic sequelae include dysglycemia accumulation glycogen kidney liver. However, there are no descriptions literature possible neuropsychiatric manifestations FBS. This case report our knowledge first this regard, describing patient with who was admitted...
Little is known about the characteristics and causes of early-onset cognitive impairment. Responders to 2001 New York World Trade Center disaster represent an ageing population that was recently shown have excess prevalence Neuroimaging molecular data demonstrate a subgroup affected responders may unique form parietal-dominant Alzheimer's Disease. Recent neuropsychological testing artificial intelligence approaches emerged as methods can be used identify monitor subtypes We utilized from...
Objective: World Trade Center (WTC) responders are susceptible to both cognitive and neuropsychiatric impairments, particularly chronic posttraumatic stress disorder. The present study examined self-reported behavioral impairments in a sample of 732 WTC responders, 199 whom were determined have high risk WTC-related cortical atrophy by an artificial neural network. Results: We found that at increased showed impairment across five domains: motivation, mood, disinhibition, empathy, psychosis...