A5026066700- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Occupational Health and Performance
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Noise Effects and Management
- Intensive Care Unit Cognitive Disorders
- Injury Epidemiology and Prevention
- COVID-19 Clinical Research Studies
- Older Adults Driving Studies
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Resilience and Mental Health
- Mental Health via Writing
- Neurobiology of Language and Bilingualism
- Anesthesia and Neurotoxicity Research
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Machine Learning in Healthcare
- Reproductive Health and Contraception
- Hearing Loss and Rehabilitation
Stony Brook University
2019-2025
Stony Brook School
2020-2025
World Trade Club
2024
Vanderbilt University
2023
University of Maryland, Baltimore
2022
West Virginia University
2020
This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis prospective cohort WTC responders.Incidence MCI was assessed clinical sample responders (N = 1800) who cognitively intact at baseline assessment. Crude rates calculated compared to population estimates using standardized ratios. Multivariable analyses used Cox proportional-hazards...
Reports suggest that the individuals who served in rescue operations following terrorist attacks on World Trade Center (WTC) have poorer brain health than expected.
Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods WTC (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed 34 regions of interest. Region-based and surface-based morphometry CI versus unimpaired responders. measures were also compared to published norms. Results Participants 55.8 (SD 0.52) years old; 48 had CI. Compared responders,...
World Trade Center (WTC) responders who aided in the search and rescue efforts are now at midlife, evidence has demonstrated that many experiencing early-onset cognitive impairment risk of developing dementia, such as Alzheimer's disease (AD). According to recent NIA-AA framework, AD is characterized by a neuropathological cascade commencing with β-amyloid deposition (A), followed tauopathy (T) neurodegeneration (N). However, ATN model not been replicated utilizing recently validated...
Abstract Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum responders with impairment (CI). In first examine cerebellar cortical thickness WTC CI, we fielded a structural magnetic resonance imaging protocol. ( N = 99) participated (MRI) study, whom 48 had CI. Participants CI did not differ demographically or by...
Abstract Introduction World Trade Center (WTC) responders are experiencing a high risk of mild cognitive impairment (MCI) and dementia, though the etiology remains inadequately characterized. This study investigated whether WTC exposures chronic post‐traumatic stress disorder (PTSD) were correlated with plasma biomarkers characteristic Alzheimer's disease (AD) neuropathology. Methods Eligible participants included WTC‐exposed individuals baseline assessment available sample. We examined...
Chronically re-experiencing the memory of a traumatic event might cause glial response. This study examined whether activation would be associated with PTSD in responders present after 9/11 World Trade Center attacks without comorbid cerebrovascular disease.
Abstract Posttraumatic stress disorder (PTSD) has been linked to increased prevalence and incidence of cognitive physical impairment. When comorbid, these conditions may be associated with poor long‐term outcomes. We examined associations between chronic PTSD symptom domains functioning in World Trade Center (WTC) responders nearly 20 years after the September 11, 2001, terrorist attacks. Participants included a cross‐sectional sample 4,815 who attended monitoring program 2015–2018. Montreal...
Abstract Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following terrorist attacks 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T 1 MRI images, reported reduced in variety psychiatric and neurological conditions. In this...
Abstract Introduction The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and vivo volumetric measures hippocampal subfield volumes WTC at midlife. Methods A sample 99 divided into unimpaired groups. Participants underwent structural T1‐weighted magnetic resonance imaging. Volumetric included the overall hippocampus eight subfields. Regression models examined measure interest adjusting for confounders including intracranial...
The individuals who served our country in the aftermath of attacks on World Trade Center (WTC) following 11 September 2001 have, since then, been diagnosed with a number conditions as result their exposures. In present study, we sought to determine whether these were risk factors for increased COVID-19 disease severity within cohort N = 1280 WTC responders complete information health outcomes prior and infection. We collected data COVID-19, or had evidence receiving positive SARS-CoV-2...
Abstract Background Recent reports suggest that World Trade Center (WTC) responders are at increased risk for cognitive impairment (CI). The current study utilized neuroimaging to determine whether WTC with CI have reduced cortical thickness (CTX). Method (N=99) and without CI, recruited from an epidemiologic of aging among responders, participated in a included T1‐MPRAGE protocol. CTX was computed 34 Desikan‐Killiany atlas regions interest (ROIs). Regional between non‐CI were compared using...
Background New York City and Long Island, NY were early foci of the COVID-19 epidemic in US. The effects on different sub-populations, its key epidemiologic parameters remain unknown or highly uncertain. We investigated epidemiology from January to August 2020 an established academic monitoring cohort N = 9,697 middle-aged World Trade Center responders residing NY. Methods A seroprevalence survey a series cross-sectional surveys nested prospective study. Measures included IgG antibody...
Research into COVID-19-related cognitive decline has focused on individuals who are cognitively impaired following hospitalization for COVID-19. Our objective was to determine whether emerged after the onset of COVID-19 and more pronounced in patients with postacute sequelae SARS-CoV-2 infection (PASC).
ABSTRACT Background The emergency personnel who responded to the World Trade Center (WTC) attacks endured severe occupational exposures, yet prevalence of cognitive impairment remains unknown among WTC‐exposed‐FDNY‐responders. present study screened for mild and in WTC‐exposed FDNY responders using objective tests, compared rates a cohort non‐FDNY responders, descriptively meta‐analytic estimates MCI from global, community, clinical populations. Methods A sample WTC‐exposed‐FDNY ( n = 343)...
Background: There is a high incidence of cognitive impairment among World Trade Center (WTC) responders, comorbid with post-traumatic stress disorder (PTSD). Yet, it remains unknown whether genetic liability for Alzheimer’s disease, PTSD, educational attainment, or combination these phenotypes, associated in this high-risk population. Similarly, the effects are comparable to PTSD and indicators exposure severity unknown. Objective: In study 3,997 WTC polygenic scores attainment were used...
Abstract Introduction The clock drawing task (CDT) is frequently used to aid in detecting cognitive impairment, but current scoring techniques are time‐consuming and miss relevant features, justifying the creation of an automated quantitative approach. Methods We computer vision methods analyze stored scanned images ( N = 7,109), intelligent system was created examine these files a study aging World Trade Center responders. Outcomes were CDT, Montreal Cognitive Assessment (MoCA) score,...
Abstract Multimodal imaging using network connectivity techniques shows promise for investigating neuropathology influencing Post-Traumatic Stress Disorder (PTSD) symptom maintenance and course. We recruited World Trade Center (WTC) responders who continued to suffer from chronic PTSD into a diffusion tensor neuroimaging protocol (n = 100), along with nine unexposed controls without other sources. Using graph theory approach probe alterations in brain images, we calculated weighted...
Abstract Responders to the World Trade Center (WTC) attacks on 9/11/2001 inhaled toxic dust and experienced severe trauma for a prolonged period. Studies report that WTC site exposure duration is associated with peripheral inflammation risk developing early-onset dementia (EOD). Free Water Fraction (FWF) can serve as biomarker neuroinflammation by measuring in vivo movement of free water across neurons. The present case-controlled study aimed examine associations between well EOD status...
World Trade Center (WTC) responders have a high risk of early-onset cognitive impairment (CI), but little is known about the etiology including extent to which CI in WTC accompanied by cortical atrophy as common progressive diseases causing age-related such Alzheimer's disease and related dementias. In current study, we entrained an artificial neural network (ANN) determine accuracy thickness (CTX) on magnetic resonance imaging identify at midlife (aged 44-65 years) with possible dementia.A...
More than 8% of responders who participated in the search and rescue efforts at World Trade Center (WTC) following 9/11 developed early-onset cognitive impairment (CI). Approximately 23% were also diagnosed with chronic post-traumatic stress disorder (PTSD).
Abstract Background Cognitive impairment is the most common and disabling manifestation of post-acute sequelae SARS-CoV-2. There an urgent need for application more stringent methods evaluating cognitive outcomes in research studies. Objective To determine whether decline emerges with onset COVID-19 it pronounced patients Post-Acute Sequelae SARS-CoV-2 or severe COVID-19. Methods This longitudinal cohort study compared performance 276 to that 217 controls across four neuroinflammation...
Little is known about the characteristics and causes of early-onset cognitive impairment. Responders to 2001 New York World Trade Center disaster represent an ageing population that was recently shown have excess prevalence Neuroimaging molecular data demonstrate a subgroup affected responders may unique form parietal-dominant Alzheimer's Disease. Recent neuropsychological testing artificial intelligence approaches emerged as methods can be used identify monitor subtypes We utilized from...