A5054539574- Influenza Virus Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Respiratory viral infections research
- Immune Cell Function and Interaction
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Proteoglycans and glycosaminoglycans research
- Malaria Research and Control
- Virology and Viral Diseases
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Xenotransplantation and immune response
- Herpesvirus Infections and Treatments
- Mast cells and histamine
- Ion Transport and Channel Regulation
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
Vaxess Technologies (United States)
2024
Human Immunome Project
2022
Crozet BioPharma (United States)
2022
VaxInnate (United States)
2007-2016
United States Military Academy
2002-2008
Merck (Japan)
2003
University of Oxford
1997-2000
Institute of Molecular Medicine
1995-1997
John Radcliffe Hospital
1994-1997
University of North Carolina at Chapel Hill
1991-1996
We describe the efficacy of L-870812, an inhibitor HIV-1 and SIV integrase, in rhesus macaques infected with simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression viremia, preserving levels permitting induction virus-specific cellular immunity. was also active chronic infection; however, magnitude durability effect varied conjunction pretreatment immune response viral load. These studies demonstrate...
The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaques using an SIVmac239 challenge. Cohorts either Mamu-A*01(+) or Mamu-A*01(-) were immunized with a prime-Ad5 boost regimen; for comparison, third cohort consisting monkeys the Ad5 vector alone both prime boost. All animals, along unvaccinated control cohorts macaques, challenged intrarectally SIVmac239. Viral...
Abstract Background Cytokine flow cytometry (CFC) or intracellular cytokine staining (ICS) can quantitate antigen-specific T cell responses in settings such as experimental vaccination. Standardization of ICS among laboratories performing vaccine studies would provide a common platform by which to compare the immunogenicity different candidates across multiple international organizations conducting clinical trials. As such, study was carried out several involved HIV trials, define inter-lab...
ABSTRACT Influenza virus is a global health concern due to its unpredictable pandemic potential. This potential threat was realized in 2009 when an H1N1 emerged that resembled the 1918 antigenicity but fortunately not nearly as deadly. 5J8 human antibody potently neutralizes broad spectrum of viruses, including and viruses. Here, we present crystal structure Fab complex with bacterially expressed refolded globular head domain from hemagglutinin (HA) A/California/07/2009 (H1N1) virus....
It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency linked antigens. We have used this approach to generate novel influenza vaccines fuse globular head domain protective hemagglutinin (HA) antigen with potent TLR5 ligand, flagellin. These fusion proteins are efficiently expressed in standard E. coli fermentation systems HA moiety can be faithfully refolded take on native conformation head. In mouse models infection, elicit robust...
The CD44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it functions as receptor for hyaluronan-mediated motility. Recently, interest has centered heparan sulfate proteoglycan (HSPG) because their potential to sequester heparin-binding growth factors and chemokines. Expression these ectodermal cells recently been shown regulate limb morphogenesis via presentation fibroblast factor (FGF) 4/FGF 8 while expression tumor was hepatocyte promote dissemination. To...
Nearly half of HLA-A2-positive individuals in African populations have a subtype HLA-A2 other than the A*0201 allele. We isolated common genes from Epstein-Barr virus-transformed B cell lines and established stable class I reduced transfectants expressing these alleles. studied peptide binding presentation properties A*0201, A*0202, A*0205, A*0214, A*6901 by combination approaches: assaying direct labeled synthetic peptides, studying ability antigen-specific cytotoxic T lymphocytes to...
Expression of several major histocompatibility complex (MHC) class I alleles is associated with a protective effect against disease progression in both human immunodeficiency virus type 1 and simian infection. To understand the mechanism underlying this effect, we investigated expression MHC allele Mamu-A*01 simian-human (SHIV) infection, one models for evaluation AIDS vaccine candidates. We found that was significantly delayed Mamu-A*01-positive rhesus monkeys infected highly pathogenic...
Background Currently controversy exists about the immunogenicity of seasonal trivalent influenza vaccine in certain populations, especially elderly. STF2.4×M2e (VAX102) is a recombinant fusion protein that links four copies ectodomain virus matrix 2 (M2e) antigen to Salmonella typhimurium flagellin, TLR5 ligand. The objectives this study were assess feasibility giving VAX102 and TIV combination an effort achieve greater provide cross-protection. Methodology/Principal Findings Eighty healthy...
We have previously demonstrated that the globular head of hemagglutinin (HA) antigen fused to flagellin Salmonella typhimurium fljB (STF2, a TLR5 ligand) elicits protective immunity H1N1 and H5N1 lethal influenza infections in mice (Song et al., 2008, PLoS ONE 3, e2257; Song 2009, Vaccine 27, 5875–5888). These fusion proteins can be efficiently economically manufactured E. coli fermentation systems as next generation pandemic seasonal vaccines. Here we report immunogenicity efficacy results...
Background The MIMIX platform is a novel microneedle array patch (MAP) characterized by slowly dissolving tips that deploy into the dermis following application. We describe safety, reactogenicity, tolerability and immunogenicity for MAP vaccination against influenza. Methodology trial was Phase 1, exploratory, first-in-human, parallel randomized, rater, participant, study analyst-blinded, placebo-controlled in Canada. Forty-five healthy participants (18 to 39 years of age, inclusive) were...
Human memory T lymphocytes have recently been re-defined as central or effector cells (Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Nature 1999. 401: 708-712). Effector (T(em)) are targeted to the peripheral tissues show rapid function in response antigenic stimulation. Central (T(cm)) lymph nodes cannot be immediately activated. In this report HLA-A2-Epstein-Barr virus (EBV) peptide tetramers used characterize EBV-specific CD8+ cell subsets persistent EBV infection....
We previously identified an HLA-B8+ donor, NW, whose lymphoblastoid cells failed to present a B8-restricted epitope from the influenza A nucleoprotein following viral infection, although added peptide could still be presented. The failure through HLA-B8 infection appears specific for NP epitope. Here, we report that donor NW makes HLA-B2702-restricted influenza-specific CTL response in overlaps by 8 aa. Two mechanisms of this cell line are investigated. One is there antigen processing...
The majority of untreated human immunodeficiency virus (HIV) type 1–infected individuals ultimately develop uncontrolled viremia and progressive disease. Cytotoxic T lymphocytes (CTLs) are known to play an important role in controlling HIV-1 replication, which has led increasing interest augmenting conventional antiretroviral therapy with therapeutic vaccination. successful development a vaccine will rely on the ability correlate aspect immune response clinical outcome. In this study, CD8+...