Flávio Santos da Silva

ORCID: 0000-0002-7019-0482
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Research Areas
  • Tendon Structure and Treatment
  • Cardiac Fibrosis and Remodeling
  • Gene expression and cancer classification
  • Protease and Inhibitor Mechanisms
  • Bone Metabolism and Diseases
  • Natural Antidiabetic Agents Studies
  • Cannabis and Cannabinoid Research
  • Bone health and osteoporosis research
  • Cardiovascular Disease and Adiposity
  • Diabetic Foot Ulcer Assessment and Management
  • Orthopedic Surgery and Rehabilitation
  • Diagnosis and Treatment of Venous Diseases
  • Berberine and alkaloids research
  • Cardiovascular Function and Risk Factors
  • Bioinformatics and Genomic Networks
  • Genetics and Physical Performance
  • Chronic Kidney Disease and Diabetes
  • Bee Products Chemical Analysis
  • Immune Response and Inflammation
  • Genomics, phytochemicals, and oxidative stress
  • Essential Oils and Antimicrobial Activity
  • Osteoarthritis Treatment and Mechanisms
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Muscle Physiology and Disorders
  • Exercise and Physiological Responses

Universidade Federal Rural do Semi-Árido
2017-2024

Universidade Federal do Rio Grande do Norte
2012-2016

Several studies have established an association between diabetes and alterations in bone metabolism; however, the underlying mechanism is not well established. Although zinc recognized as a potential preventive agent against diabetes-induced loss, there no evidence demonstrating its effect chronic diabetic conditions. This study evaluated effects of supplementation (90 days) type 1 bone-loss model. Male Wistar rats were distributed three groups: control, mellitus (T1DM), T1DM plus (T1DMS)....

10.1371/journal.pone.0125349 article EN cc-by PLoS ONE 2015-05-01

We investigated the role of an evidence-based integrated group rehabilitation program on treatment patients with knee osteoarthritis (KOA). This was a two-group, randomized controlled, 8 wk trial 41 moderate to very severe KOA. Patients were assigned intervention (IG) or control (CG). After both groups had received self-management education program, IG participants underwent including educational aspects about KOA followed by exercises. CG only general health orientation during this period....

10.1682/jrrd.2014.08.0199 article EN The Journal of Rehabilitation Research and Development 2015-01-01

Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy the major conservative treatment for T1DM; however, effects this hormone on bone markers T1DM rats are limited, and regulatory mechanisms remain elusive. Therefore, evaluation molecular non-molecular parameters a chronic animal model T1DM-induced loss, treated without insulin, may help elucidating insulin mechanisms. Male Wistar were assigned...

10.1111/bcpt.12672 article EN Basic & Clinical Pharmacology & Toxicology 2016-09-21

The aim of this study was to compare the treatment effects laser photobiomodulation (LPBM) therapy and aerobic exercise on biomechanical properties, tissue morphology expression tendon matrix molecules during early remodeling Achilles (AT) injury in diabetic rats. Animals were randomly assigned five groups: injured non (I, n = 15), (ID, plus LPBM (IDL, 16), (IDE, 16) (IDEAL, 17). Type 1 diabetes induced via a single intravenous injection Streptozotocin at dose 40 mg/kg. A partial tenotomy...

10.1371/journal.pone.0211643 article EN cc-by PLoS ONE 2019-02-04

The purpose of this study is to examine current beliefs about the use, clinical importance, theoretical fundamentals and utilization criteria therapeutic ultrasound (TUS) among physical therapists on practice in orthopedic sports physiotherapy Brazil.A brief survey was developed based previous studies sent 55 with advanced competency orthopedics physiotherapy. questions addressed general topics professional profile usage dosage.Our data show wide availability frequent use TUS sample...

10.1186/2036-7902-4-11 article EN cc-by Critical Ultrasound Journal 2012-05-28

S-methyl cysteine sulfoxide (SMCS) is a hydrophilic cysteine-containing natural compound found in plants and known to possess antidiabetic antioxidant properties. We investigated the immunomodulatory properties of SMCS, as well histopathological changes liver pancreas streptozotocin (STZ)-induced diabetic rats.The rats were divided into following groups: control (CG), comprising non-diabetic rats; STZ-DB, STZ-induced STZ-SMCS, treated with SMCS. SMCS (200 mg/kg) was administered by gavage...

10.1515/jcim-2020-0220 article EN Journal of Complementary and Integrative Medicine 2021-08-03

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed 12 cigarettes/day/5days treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) CSE (5%) In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance pro-inflammatory cytokine release while increasing anti-inflammatory one. These results...

10.3390/antiox12061258 article EN cc-by Antioxidants 2023-06-11

Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispermaceae) plant used to treat respiratory diseases. The aim this study was evaluate effect extract (CSE) in lungs diabetic rats. We 30 Wistar rats divided into three groups: control group (CG), (DG) and treatment (DTG). induced streptozotocin (40 mg/kg i.v.). CSE (400 mg/kg, po) administered daily, during four...

10.1590/s2175-97902019000417374 article EN cc-by Brazilian Journal of Pharmaceutical Sciences 2020-01-01

Metalloproteinases play a role in repair of venous ulcers the lower limbs. The great majority studies metalloproteinase enzyme activity conducted to date have employed material from biopsies ulcers. We evaluated viability using zymography measure metalloproteinases 2 and 9 samples ulcer exudate collected on swabs. method chosen for processing proved viable terms its ability provide adequate protein concentrations analysis. Using zymography, we observed that parameters provided best results...

10.1590/jvb.2014.038 article EN cc-by Jornal Vascular Brasileiro 2014-09-01

Diabetes mellitus is a metabolic disorder that can generate tissue damage through several pathways. Alteration and dysfunction of skeletal muscle are reported including respiratory muscles, which may compromise parameters in diabetic patients. We have aimed to evaluate the diaphragm contractility, remodeling, oxidative stress, inflammatory from 30 day streptozotocin-treated rats. The contractility was assessed using isolated muscle, remodeling histology zymography techniques, stress by...

10.1139/cjpp-2019-0609 article EN Canadian Journal of Physiology and Pharmacology 2020-04-03

<div>Introdução: Embora seja o mais forte dentre os tendões humanos, tendão calcâneo (TC) é comumente afetado por condições patológicas e/ou traumáticas. Apesar da prevalência e tratamento complexo, a patomecânica tendinopatia do continua desconhecida. Equipamentos capazes de mensurar as propriedades biomecânicas TCs são indispensáveis em estudos que visam elucidar fatores responsáveis pela ou influenciem reparo tecidual. Objetivo: Desenvolver um dispositivo, baixo custo, acoplado...

10.9771/cmbio.v12i1.6429 article PT cc-by Revista de Ciências Médicas e Biológicas 2013-08-20
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