A5005919671- Natural Antidiabetic Agents Studies
- Curcumin's Biomedical Applications
- Biochemical effects in animals
- Muscle Physiology and Disorders
- Antioxidant Activity and Oxidative Stress
- Paraoxonase enzyme and polymorphisms
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Aquaculture Nutrition and Growth
- Phytochemistry and biological activity of medicinal plants
- Adipose Tissue and Metabolism
- Alcoholism and Thiamine Deficiency
- Advanced Glycation End Products research
- Bone health and osteoporosis research
- Sugarcane Cultivation and Processing
- Polyamine Metabolism and Applications
- Synthesis of heterocyclic compounds
- Bone health and treatments
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
- Saffron Plant Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Biomedical Research and Pathophysiology
- Phytochemical and Pharmacological Studies
- Diet and metabolism studies
Universidade Estadual Paulista (Unesp)
2014-2022
Universidade Federal de São Paulo
2022
Centro Universitário de Araraquara
2015-2019
Universidade de São Paulo
2018
Universidade de Ribeirão Preto
2011-2013
This study measures the curcumin concentration in rat plasma by liquid chromatography and investigates changes glucose tolerance insulin sensitivity of streptozotocin-diabetic rats treated with curcumin-enriched yoghurt. The analytical method for detection was linear from 10 to 500 ng/mL. C max time reach (t max) were 3.14 ± 0.9 μg/mL 5 minutes (10 mg/kg, i.v.) 0.06 0.01 14 (500 p.o.). elimination half-time 8.64 2.31 (i.v.) 32.70 12.92 (p.o.) minutes. oral bioavailability about 0.47%....
Combination therapy using natural antioxidants to manage diabetes mellitus and its complications is an emerging trend. The aim of this study was investigate the changes promoted by treatment streptozotocin (STZ)-diabetic rats with yoghurt enriched bioactives curcumin, lycopene, or bixin (the latter two being carotenoids). Antioxidants were administered individually, as mixtures, biomarkers metabolic oxidative disturbances, particularly those associated cardiovascular risk, assessed....
Knowing that curcumin has low bioavailability when administered orally, and piperine bioenhancer activity by inhibition of hepatic intestinal biotransformation processes, the aim this study was to investigate antidiabetic antioxidant activities (90 mg/kg) (20 or 40 mg/kg), alone co-administered, incorporated in yoghurt, streptozotocin (STZ)-diabetic rats. The treatment for 45 days STZ-diabetic rats with curcumin-enriched yoghurt improved all parameters altered experimental model diabetes:...
Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, gained attention due beneficial effects in controlling the disturbances observed mellitus. The purpose this study was investigate if yoghurt enriched curcumin metformin, individually or mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers,...
Insulin with natural antioxidants is emerging as a combination treatment for diabetes mellitus that attempts to exert effective glycemic control without adverse effects. The present study aimed investigate the additive effects on metabolic disturbances, oxidative damage, and antioxidant defenses in streptozotocin‐diabetic rats treated curcumin reduced insulin dose. best results were obtained of diabetic 4‐U/day insulin; however, glycemia levels these lower than those normal rats, indicating...
There have been few studies on the pharmacological properties of Rhamnus sphaerosperma var. pubescens , a native Brazilian species popularly known as “fruto‐de‐pombo.” The aim this study was to investigate scavenging capacity emodin, physcion, and ethanolic crude extract against reactive oxygen nitrogen species, well their role plausible mechanisms in prompting cell death changes AKT phosphorylation after cervical (SiHa C33A) oral (HSC‐3) squamous carcinoma treatments. Emodin shown be best...
Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy the major conservative treatment for T1DM; however, effects this hormone on bone markers T1DM rats are limited, and regulatory mechanisms remain elusive. Therefore, evaluation molecular non-molecular parameters a chronic animal model T1DM-induced loss, treated without insulin, may help elucidating insulin mechanisms. Male Wistar were assigned...
Advances in the knowledge of mechanisms controlling protein breakdown skeletal muscles have allowed exploration new options for treating muscle-wasting conditions. Pentoxifylline (PTX), a nonselective phosphodiesterase (PDE) inhibitor, attenuates loss muscle mass during catabolic conditions, mainly via inhibiting breakdown. The aim this study was to explore by which PTX inhibits proteolysis soleus and extensor digitorum longus (EDL) streptozotocin-induced diabetic rats. levels atrogin-1 RING...
Diabetes mellitus is a disease characterized by persistent hyperglycemia, which may lead to brain tissue damage due oxidative stress and also contributes neuronal death changes in synaptic transmission. This study evaluated the effect of use antioxidants supplementation on myosins expression levels brains chronic diabetic rats induced streptozotocin. Lipid peroxidation, antioxidant enzymes activities, myosins-IIB -Va expressions at transcriptional translational were examined after 90 days...
In view of the prevalence oxidative stress in chronic kidney disease (CKD) patients, loss low-molecular-weight biomolecules by hemodialysis and antioxidant potential some uremic solutes that accumulate CKD, we used vitro model systems to test following solutes: uric acid, hippuric p-cresol, phenol, methylguanidine, L-arginine, L-tyrosine, creatinine urea. The efficiencies solutes, isolated or mixtures, were tested with assays: i) ABTS radical cation decolorization assay; ii) hypochlorous...
O objetivo deste estudo foi detectar a presença de antraceno, naftaleno, benzo[e]pireno e dibenzo[a,h]antraceno na fuligem da cana-de-açúcar avaliar toxicidade in vivo por meio frequência média aberrações cromossômicas. A análise cromatográfica (em fase gasosa) efetuada revelou dos hidrocarbonetos policíclicos aromáticos (HPA) estudados. teste micronúcleo, realizado em células ósseas camundongos, mostrou que apareceram com aumentada no micronúcleo nas doses testadas. No entanto, o antraceno...
Abstract Purpose Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. Methods The stereoisomers of were used against human tongue squamous cell line and negative stereoisomer showed lower IC50. 31 Holtzman rats (120-130 grams) cancer by (4-NQO/8 weeks/25 ppm) 32 Healthy toxicity experiments. Six groups used, healthy, 0.1nL/g TP-4-ol, 8nL/g 4-NQO, 4-NQO+0.1nL/g 4-NQO+8nL/g TP-4-ol. We performed analysis biochemical histopathological...