A5065099795- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Immunotherapy and Immune Responses
- Plant Reproductive Biology
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Animal Virus Infections Studies
King's College London
2022-2024
Instituto de Biología Molecular y Celular de Plantas
2023
Consejo Superior de Investigaciones Científicas
2023
Universitat Politècnica de València
2023
Medical Research Council
2022
King's College Hospital
2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017-2020
Hospital Clínic de Barcelona
2017-2020
Universitat de Barcelona
2017-2020
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017-2020
Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this study was analyse the HBV-specific T cell response, parallel peripheral and intrahepatic viral parameters, undergoing NA discontinuation.Twenty-seven without cirrhosis CHB complete suppression (>3 years) were studied prospectively. Intrahepatic HBV-DNA (iHBV-DNA), HBV-RNA (iHBV-RNA), covalently...
CD4
Abstract Background & Aims Acute hepatitis A is transmitted mainly via the faecal‐oral route and/or contaminated aliment. Furthermore, several outbreaks in men who have sex with ( MSM ) population classified as a sexually disease STD ). We aimed to clarify an ongoing outbreak Barcelona respect patients’ characteristics and viral phylogenetic analysis. Methods prospectively analyzed 46 cases of infection that were registered our hospital between January June 2017. evaluated demographics...
Abstract Background & Aims Detailed hepatitis C virus (HCV) kinetics modelling is scarce in patients with advanced liver disease receiving direct‐acting antivirals (DAAs). Due to budget restrictions, and health systems would benefit from the shortest possible treatment course. We investigated whether very early HCV cirrhotic under DAAs therapy could be used individualize care reduce duration achieve cure. Methods included 74 HCV‐related cirrhosis who received interferon‐free treatments...
Hepatitis E virus (HEV) and hepatitis A (HAV) are both secreted in feces. Despite HEV transmission Europe is mainly zoonotic, person-to-person has not been completely excluded. Men who have sex with men (MSM) constitute a high-risk group for HAV mostly due to oral sex. We investigated the potential of during an acute (AHA) outbreak affecting MSM. One hundred two patients were diagnosed AHA. Sixty-nine (68%) self-reported be MSM, 75% whom had sexual behaviors 46% suffered previous sexually...
Summary The emergence of resistance‐associated substitutions (RASs) can compromise the high efficacy direct‐acting antivirals (DAAs). Little is known about RASs selection at very early time points during DAA treatment. Therefore, we analyzed potential immediately after therapy initiation. Samples 71 patients treated with different DAAs were collected baseline, (hours 4 and 8; days 1‐7; weeks 2‐4) or until target not detected. HCV‐RNA levels determined by qPCR, detected deep sequencing....
Background: Chronic hepatitis C virus (HCV) infection impairs natural killer (NK) cell phenotype and function. Whether restoration of NK cells occurs after successful interferon (IFN)-free therapies remains a controversial issue. Aim: To analyze how HCV-related liver cirrhosis impacts changes in prior post-IFN-free therapies. Methods: analysis by multicolor flow cytometry was performed HCV-infected patients with (n = 17) without 14) at baseline, week 4 during therapy, weeks 12 48 the end...
Chronic hepatitis C virus (HCV) infection impairs HCV CD8+ T-cell responses, while it could influence immune responses towards unrelated viruses/vaccines (e.g. cytomegalovirus, CMV, and influenza, Flu). The aim of our study was to delineate whether restoration these virus-specific T cells occurs after direct-acting antiviral (DAA) therapies particularly in patients with cirrhosis. We performed longitudinal analysis (baseline, week 4, follow-up [FU] 12 FU48) by multicolour flow cytometry...
Abstract The DEVIL/ROTUNDIFOLIA-LIKE (DVL/RTFL) family of plant peptides is present in all land plants, but their biological role and mode action remains largely unknown, part due to the lack reported phenotypes associated DVL/RTFL loss function. In this work we have generated high order mutants characterized reproductive development. Our results indicate that dvl are affected cell elongation processes, mainly related pollen tube growth, they appear provide robustness these processes. We...