A5067773937- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Diet, Metabolism, and Disease
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Alcohol Consumption and Health Effects
- Mast cells and histamine
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Assays
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Pulmonary Hypertension Research and Treatments
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Forensic Toxicology and Drug Analysis
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
Medical University of Białystok
2016-2025
King's College London
2016
Centro Cardiologico Monzino
2016
Institute of Experimental Cardiology
2016
Imperial College London
2016
University of Florence
2016
University of Bonn
1991-2012
Wrocław University of Science and Technology
2012
October 6 University
1997
Universitat de les Illes Balears
1996
We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate (HR) in spontaneously (SHR) deoxycorticosterone (DOCA-salt) hypertensive rats. Hypertension was connected with increases cardiac plasma markers lipid peroxidation both models, whereas endocannabinoid levels decreased SHR increased DOCA-salt. CBD (10 mg/kg once a day for 2 weeks) did not modify BP HR hypertension but counteracted pro-oxidant effects. Moreover, it or anandamide, 2-arachidonoylglycerol...
Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric (sMAs). Methods: Vascular effects CBD were examined hPAs obtained from patients during resection lung carcinoma sMAs spontaneously hypertensive (SHR); 11-deoxycorticosterone acetate (DOCA-salt) rats or their appropriate normotensive controls using organ bath wire myography,...
Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties. The aim of our study was to examine potential preventive effect chronic CBD administration (10 mg/kg/day three weeks) on monocrotaline (MCT)-induced hypertension (PH) rats. PH connected with elevation right ventricular systolic pressure; ventricle hypertrophy; lung edema; artery remodeling; enhancement vasoconstrictor decreasing vasodilatory...
Pulmonary hypertension (PH) is a progressive disease characterized by elevated blood pressure in the pulmonary arteries, associated also with inflammation and oxidative stress. Inducible nitric oxide synthase (iNOS) one of key mediators immune system activation. Although preclinical studies mostly suggest detrimental role iNOS overactivation PH, there lack exhaustive analyses summaries. Therefore, this literature overview aims to fill gap. The involvement pathogenesis four main clinical...
The influence of β 1 , 2 and 3 ‐adrenoceptor agonists CGP 12177 cyanopindolol on heart rate diastolic blood pressure was studied in the pithed rat. agonist, prenalterol, increased fenoterol, caused a fall pressure. effect prenalterol antagonized by antagonist, 20712 0.1 μ m ol kg −1 action fenoterol attenuated ICI 118551 . Both effects were markedly diminished non‐selective β‐adrenoceptor bupranolol isoprenaline, three ‐agonists as well elicited positive chronotropic effect, exhibiting...
Cannabidiol (CBD) is a nonpsychotropic constituent of Cannabis sativa L. It suggested to be useful in hypertension. Under vitro conditions, it activates vanilloid TRPV1 and inhibits serotonin 5-HT3 receptors, i.e., receptors involved the Bezold-Jarisch reflex stimulation. The aim our study was compare cardiovascular effects CBD spontaneously hypertensive (SHR) normotensive Wistar Kyoto (WKY) rats. Experiments were performed on conscious, urethane-anesthetized, pithed In SHR WKY, increased...
Background The endocannabinoid anandamide is implicated in the pathogenesis of hypotension haemorrhagic, endotoxic, and cardiogenic shock. It has been demonstrated animal, but not human, vessels that vasodilatory effects abnormal cannabidiol are partially mediated by an as yet unidentified endothelial cannabinoid receptor. Our study was performed to examine influence on human pulmonary artery. Methods Isolated arteries were obtained from patients without clinical evidence hypertension during...
The endocannabinoid virodhamine is a partial agonist at the cannabinoid CB(1) receptor and full CB(2) receptor, relaxes rat mesenteric arteries through endothelial receptors. Its concentration in periphery exceeds that of anandamide. Here, we examined influence on human pulmonary artery.Isolated were obtained during resections for lung carcinoma. Vasorelaxant effects endothelium-intact vessels precontracted with 5-HT or KCl.Virodhamine, unlike WIN 55,212-2, relaxed 5-HT-precontracted...
Recent evidence suggests that endocannabinoids acting via cannabinoid CB 1 receptors may modulate vascular responses of various vasoconstrictors in the rodent systemic vasculature. The aim study was to investigate whether contractile evoked by a thromboxane A 2 analog (U46619), angiotensin II (ANG II), serotonin (5-HT), and phenylephrine, which stimulate distinct G q/11 protein-coupled (thromboxane, ANG type 1, 5-HT , α -adrenergic receptors) isolated endothelium-intact human rat pulmonary...