A5054257763- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Bone health and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Congenital Heart Disease Studies
- Homelessness and Social Issues
- Bone health and osteoporosis research
- Parvovirus B19 Infection Studies
- Breastfeeding Practices and Influences
- Craniofacial Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Congenital Diaphragmatic Hernia Studies
- Cytomegalovirus and herpesvirus research
- Cleft Lip and Palate Research
- Epilepsy research and treatment
- Cardiac Ischemia and Reperfusion
- Pericarditis and Cardiac Tamponade
- Bone Metabolism and Diseases
- Child and Adolescent Health
- Antimicrobial Resistance in Staphylococcus
- Neural dynamics and brain function
Children's Hospital at Westmead
2014-2024
The University of Sydney
2016-2024
National Institute of Mental Health and Neurosciences
1982
Edward Hospital
1963
We describe the clinical presentations of 118 infants admitted to hospital in New South Wales, Australia, during an epidemic human parechovirus type 3. Infants presented with acute sepsis-like syndrome a high rate intensive care admission. Background. Infections parechoviruses (HPeVs) are associated wide range children, ranging from mild or asymptomatic infections severe meningoencephalitis. Methods. reviewed medical records 5 hospitals outbreak HPeV-3 infection. Data were collected on...
Abstract Cantú syndrome (CS), characterized by hypertrichosis, distinctive facial features, and complex cardiovascular abnormalities, is caused pathogenic variants in ABCC9 KCNJ8 genes. These genes encode gain‐of‐function mutations the regulatory (SUR2) pore‐forming (Kir6.1) subunits of K ATP channels, respectively, suggesting that channel‐blocking sulfonylureas could be a viable therapy. Here we report neonate with CS, carrying heterozygous variant (c.3347G>A, p.Arg1116His), born...
Aim Amplitude‐integrated electroencephalogram ( aEEG ) is widely used in neonates to detect electrical seizure and predict outcome following hypoxic ischaemic encephalopathy other encephalopathy. Because accurate interpretation important for clinical decision‐making family counselling, inter‐observer reliability a major concern. We aimed evaluate the of tracings neonatal intensive care unit. Methods Three unit clinicians with different levels experience reading independently reviewed scored...
Objective Awareness of the need for early identification and treatment sleep disordered breathing (SDB) in neonates is increasing but challenging. Unrecognised SDB can have negative neurodevelopmental consequences. Our study aims to describe clinical profile, risk factors, diagnostic modalities interventions that be used manage with facilitate recognition improved management. Methods A single-centre retrospective referred assessment suspected a tertiary newborn intensive care unit New South...
We report a preterm (35 4/7 weeks) male neonate with Down's syndrome (DS) diagnosed isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours life respiratory distress, anemia due to feto-maternal bleed, hypotension, hepatomegaly, coagulopathy. Postnatal echocardiography confirmed 5 mm rim PE without tamponade, normal cardiac structure, function. stabilized ventilation, packed red cell, fresh...
The authors aimed to evaluate preoperative amplitude-integrated electroencephalography (aEEG) patterns for predicting neurodevelopmental outcome among infants undergoing major surgery in the neonatal period. They retrospectively reviewed aEEG data of 58 neonates who had undergone between 2006 and 2008. classified aEEGs using a weighted background score. Neurodevelopmental was assessed at 3 years age Bayley Scales Toddler Infant Development III. Over third (36%) showed an abnormal background....
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Objectives: Understanding the long-term consequences of sleep-disordered breathing (SDB) in neonates is crucial. A lack consensus on diagnostic and treatment thresholds has resulted limited research this area. Our study aims to describe trajectory SDB a cohort high-risk their respiratory neurodevelopmental outcomes at 3 years age, explore relationship between during early infancy neurocognitive outcomes. Methods: retrospectively identified with moderate–severe were prospectively followed...
There is strong evidence of a link between parental substance use and/or mental health problems and adverse outcomes in children. We wanted to know the impact these early childhood adversities on social also determine whether identification risks made difference child's outcome what effective strategies interventions are available that will ensure safety children, provide support for them improve their long-term outcomes.This was retrospective analysis children attending specialized...
Objective To determine the practices of neonatologists in managing high-risk neonates believed to be at risk sleep disordered breathing (SDB). Design An electronic web-based questionnaire assessing awareness and current for predisposed SDB with conditions like craniofacial anomalies, neuromuscular disorders or airway problems was emailed 232 neonatal fellows working Australia New Zealand (NZ). Additionally, were approached directly during annual NZ perinatal conference 2019. Results 93 (40%)...