A5065711202- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Adenosine and Purinergic Signaling
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Retinal Diseases and Treatments
- Neurological Disorders and Treatments
- Circular RNAs in diseases
- Neurological Complications and Syndromes
- Nerve injury and regeneration
- Brain Metastases and Treatment
- Cannabis and Cannabinoid Research
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Vectors
- Heme Oxygenase-1 and Carbon Monoxide
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Foot and Ankle Surgery
Affiliated Hospital of Nantong University
2016-2025
Nantong University
2016-2025
Fudan University
2012-2015
Eye & ENT Hospital of Fudan University
2015
Shanghai Center for Brain Science and Brain-Inspired Technology
2015
Korea Institute of Brain Science
2012
Government ENT Hospital
2012
Müller cell gliosis, which is characterized by upregulated expression of glial fibrillary acidic protein (GFAP), a universal response in many retinal pathological conditions. Whether down-regulation inward rectifying K + (Kir) channels, commonly accompanies the enhanced GFAP expression, could contribute to gliosis poorly understood. We investigated changes Kir currents, and Kir4.1 cells rat chronic ocular hypertension (COH) model, explored mechanisms underlying gliosis. show that currents...
Purpose: To investigate potential modes of programmed cell death in the lens epithelial cells (LECs) patients with early age-related cortical cataract (ARCC) and to explore early-stage intervention strategies. Methods: Anterior capsules were collected from ARCC for comprehensive analysis. Ultrastructural examination LECs was performed using transmission electron microscopy. Cell death–associated protein markers quantified via Western blot analysis, including those paraptosis (ALIX, GRP78),...
Background: Although prediabetes increases the risk of developing diabetes, its role in neuropathy remains unclear. We aim to assess alterations corneal nerve structure and function factors for loss. Methods: An examination IVCM sensitivity was conducted on a cohort 75 participants, comprising 23 controls, 32 prediabetes, 20 Type 2 diabetes. Semiautomatic analysis employed quantify fiber length (CNFL), density (CNFD), dendritic cell (DC) density. Results: CNFL CNFD were lower diabetes than...
Previous studies have demonstrated that activation of P2X7 receptors (P2X7R) results in the proliferation and migration some types tumor. Here, we asked whether how activated P2X7R contribute to human glioma cells. Results showed number positive cells was increasing with grade In U87 U251 cell lines, both expressed expression enhanced by 3'-O-(4-benzoylbenzoyl) ATP (BzATP), agonist P2X7R, siRNA. Our also 10 μM BzATP sufficient induce significantly, while reached peak 100 BzATP. Also,...
To assess postoperative changes in angle alpha, and to evaluate the visual quality of patients with different alpha values after implantation extended depth focus (EDOF) intraocular lenses (IOLs).Seventy-nine eyes 79 who had phacoemulsification EDOF IOLs were enrolled. A cut-off value 0.3 mm, 0.4 0.5 mm preoperative was chosen divide into groups. Distance, intermediate, near acuities, modulation transfer function (MTF), aberrations recorded during a 6-month follow-up. patient questionnaire...
Angle kappa plays a vital role in the implantation of multifocal intraocular lens (MIOL). Large angle is related to higher risk postoperative photic phenomena. This study aims compare preoperative eyes cataract patients obtained from Pentacam Scheimpflug system (Pentacam), optical low-coherence reflectometry (Lenstar), and ray-tracing aberrometry (iTrace).One hundred thirteen 113 with cataracts were included. Each eye was examined 3 times using all devices obtain pupil diameter. When...
Abstract Background In the present study, we explored role of N 6 -methyladenosine (m A) modification long non-coding RNAs (lncRNAs) and its association with ferroptosis in lens epithelium cells (LECs) age-related cataract (ARC). Methods Through m A RNA immunoprecipitation sequencing A-RIP-seq) (RNA-seq), identified mediated differentially expressed lncRNAs (dme-lncRNAs) ARC patients. Based on bioinformatics analysis, selected critical dme-lncRNAs pathways associated formation to reveal...
P2X 7 receptor (P2X R), an ATP-gated ion channel, plays important role in glaucomatous retinal ganglion cell (RGC) apoptotic death, which activated Müller glial cells may be involved by releasing ATP. In the present study, we investigated whether and how induce changes R expression RGCs using immunohistochemistry Western blot techniques. Intravitreal injection of DHPG, a group I metabotropic glutamate (mGluR I) agonist, induced upregulation GFAP expression, suggestive activation (gliosis),...
To determine the incidence of anterior chamber (AC) instability during phacoemulsification (phaco) combined with intraocular lens implantation and investigate its effect on tissues. Among 248 enrolled eyes, 121 127 eyes were categorized into irrigation nonirrigation groups, respectively, depending use a self-made maintainer (ACM) phaco. AC stability was evaluated using operating microscopy intraoperative optical coherence tomography (iOCT). Slit-lamp examination flare cells performed 1 day...
To explore the value of visual electrophysiology in evaluating fundus function mature cataract patients.124 patients (153 eyes) were examined before surgery; examinations included best corrected acuity (BCVA), pattern evoked potential (PVEP), full-field electroretinogram (ffERG), and multifocal (mfERG). According to postoperative conditions, subjects divided into two groups: no disease group group. Approximately one month after operation, BCVA was measured, performed on who had a stable...
<title>Abstract</title> <bold>Background:</bold> Premium intraocular lens (IOL) can provide a fixed distance of near vision, which may be affected for patients who prefer different distances. Thus, this study evaluate the effects and comfortable after implantation extended depth focus (EDOF), multifocal (Multi) monofocal (Mono) lenses (IOLs). <bold>Methods: </bold>Seventy eligibleparticipants were implanted with their preferred IOL completed relevant follow-up.Assessments focused on...
Abstract Background Angle kappa plays a vital role in the implantation of multifocal intraocular lens (MIOLs). Large angle is related to higher risk postoperative photic phenomena. This study aims compare preoperative eyes cataract patients obtained from Pentacam Scheimpflug system (Pentacam), optical low-coherence reflectometry (Lenstar), and ray-tracing aberrometry (iTrace). Methods One hundred thirteen 113 with cataracts were included. Each eye was examined by devices obtain (X-Y...
In present study, we explored the role of N 6 -methyladenosine (m A) modification long non-coding RNAs (lncRNAs) and their link to ferroptosis in lens epithelium cells (LECs) age-related cataract (ARC). LECs were obtained from patients with cortical (ARCC) age-matched controls who received transparent extraction. Then, via m A RNA immunoprecipitation sequencing A-RIP-seq) (RNA-seq), determined A-lncRNAs differentially expression lncRNAs. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...
Abstract Background: To assess postoperative changes in angle alpha, and to evaluate the visual quality of patients with different alpha values after implantation extended depth focus (EDOF) intraocular lenses (IOLs). Methods: Seventy-nine eyes 79 who had phacoemulsification EDOF IOLs were enrolled. A cut-off value 0.3 mm, 0.4 0.5 mm preoperative was chosen divide into groups. Distance, intermediate, near acuities, modulation transfer function (MTF), aberrations recorded during a 6-month...