A5010309754- Bacteriophages and microbial interactions
- Genetic Associations and Epidemiology
- Antibiotic Resistance in Bacteria
- Ear and Head Tumors
- Hearing, Cochlea, Tinnitus, Genetics
- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Schizophrenia research and treatment
- Salmonella and Campylobacter epidemiology
Public Health Agency of Canada
2025
University of Manitoba
2021-2024
Ciprofloxacin is important for treatment of severe or invasive Salmonella infections in humans. As laboratories transition from phenotypic to genomics-based methods determining ciprofloxacin non-susceptibility, it define the correlation between genetic determinants resistance and outcomes. Here, we examined mechanisms tested hypothesis that isolates containing only one mechanism had intermediate while two more full according breakpoints Clinical Laboratory Standards Institute. Among 13,750...
Abstract Background Cisplatin-induced ototoxicity (CIO), characterized by irreversible and progressive bilateral hearing loss, is a prevalent adverse effect of cisplatin chemotherapy. Alongside clinical risk factors, genetic variants contribute to CIO genome-wide association studies (GWAS) have highlighted the polygenicity this drug reaction. Polygenic scores (PGS), which integrate information from multiple across genome, offer promising tool for identification individuals who are at higher...