A5114929050- Heavy metals in environment
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Environmental Justice and Health Disparities
- Heavy Metal Exposure and Toxicity
- Radioactivity and Radon Measurements
- Advanced Nanomaterials in Catalysis
- Toxic Organic Pollutants Impact
- Lipid Membrane Structure and Behavior
- Arsenic contamination and mitigation
- Antimicrobial Peptides and Activities
- Characterization and Applications of Magnetic Nanoparticles
- Virus-based gene therapy research
- Biological Activity of Diterpenoids and Biflavonoids
- Nanoparticle-Based Drug Delivery
- Ginger and Zingiberaceae research
- Sesquiterpenes and Asteraceae Studies
- Hepatitis Viruses Studies and Epidemiology
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Urban Agriculture and Sustainability
- Nanoplatforms for cancer theranostics
- X-ray Diffraction in Crystallography
- Urban Green Space and Health
- Health, Environment, Cognitive Aging
Sun Yat-sen University
2019-2024
Chinese Research Academy of Environmental Sciences
2020-2023
Minzu University of China
2023
Karlsruhe Institute of Technology
2013-2020
Southeast University
2011-2014
State Key Laboratory of Digital Medical Engineering
2011-2014
Soochow University
2008
Co3O4 nanoparticles (Co3O4 NPs), synthesized by the coprecipitation method, showed intrinsic catalase-like, peroxidase-like, and SOD-like activity. The catalytic activity of NPs was much higher than analogous Fe3O4 NPs. Co3O4's mechanisms were analyzed in detail using electron spin resonance (ESR) which confirmed that don't follow classical Fenton reactions with hydrogen peroxide way do. high redox potential Co3+/Co2+ supposed to be leading cause differences both mechanism Fe3O4. Based on...
Peptide hydrogels are widely used for biomedical applications owing to their good biocompatibility and unique advantages in terms of amino acid-based structures functions. However, the exploration peptide/saccharide composite as potential biomaterials chronic diabetic wound healing is still limited. Herein, hyaluronic acid (HA) was incorporated into diphenylalanine (FF) conjugated with different aromatic moieties by a one-pot reaction. Our results showed that dipeptide derivatives modified...
Dimercaptosuccinic acid (DMSA) modified ultra-small particles of iron oxide (USPIO) were synthesized through a two-step process. The first step: oleic (OA) capped Fe3O4 (OA-USPIO) by novel oxidation coprecipitation method in H2O/DMSO mixing system, where DMSO acts as an oxidant simultaneously. second OA was replaced DMSA to obtain water-soluble nanoparticles. as-synthesized nanoparticles characterized TEM, FTIR, TGA, VSM, DLS, EDS and UV–vis. Hydrodynamic sizes Peroxidase-like catalytic...
Efficient delivery of plasmid DNA and siRNA into cells is essential for biological biomedical research. Although significant efforts have been made to develop efficient nonviral vectors, such as cationic lipids polymers, most the vectors require multistep synthesis, which complicates both fast structural optimizations combinatorial synthesis vectors. Here, we present a facile, single-step method based on an alkylation amines, allowing parallel libraries lipid-like molecules (lipidoids). We...
A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
Qiyuan Liu*, Yihang Wu*, Wenhao Zhao, Jin Ma*, Yajing Qu, Haiyan Chen, Yuxin Tian & Fengchang WuState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy Sciences, Beijing, China
Abstract: Metabolic reprogramming of cells, from the normal mode glucose metabolism named glycolysis, is a pivotal characteristic impending cancerous cells. Pyruvate kinase M2 (PKM2), an important enzyme that catalyzes final rate-limiting stage during highly expressed in numerous types tumors and aids development favorable conditions for survival tumor Increasing evidence has suggested PKM2 one promising targets innovative drug discovery, especially developments antitumor therapeutics....
Cationic lipid-like molecules (lipidoids) are widely used for in vitro and vivo gene delivery. Nearly all lipidoids developed to date employ double-tail or multiple-tail structures transfection. Single-tail seldom considered transfection as they have low efficiency So far, there is no detailed study on the contribution of single-tail when combined with standard lipidoids. Here, we use combinatorial chemistry synthesize 17 using thiol-yne thiol-ene click chemistry, respectively. HEK 293T...