The purpose of this study was to investigate whether lavender oil aromatherapy can reduce the bispectral index (BIS) values and stress decrease pain needle insertion in 30 volunteers.Thirty (30) healthy volunteers were randomly allocated 2 groups: experimental group received oxygen with a face mask coated for 5 minutes, control through no minutes. level (0=no stress, 10=maximum stress), BIS value, intensity pain, 10=worst imaginable) measured.There significant differences age, sex, height,...

Objective The purpose of this study was to verify the appropriateness ovariectomized rats as osteoporosis animal model. Methods Twelve female Sprague-Dawley underwent a sham operation (the group) or bilateral ovariectomy [the (OVX) group]. Eight weeks after operations, serum biochemical markers bone turnover were analyzed; osteocalcin and alkaline phosphatase, which are sensitive formation, C-terminal telopeptide fragment type I collagen C-terminus (CTX), is marker resorption. Bone...

Background and Objective . Vitamin C has antioxidant, neuroprotective, neuromodulating effects. Recently, it showed antinociceptive effect as a result of the antioxidant properties. Therefore, we designed this study to assess intravenous vitamin on opiate consumption pain in patients undergoing laparoscopic colectomy. Methods A total 100 were enrolled allocated receive 50 mg/kg or placebo by infusion immediately after induction anesthesia. Morphine scores assessed at 2, 6, 24 h completion...

Peripheral nerve injury results in chronic neuropathic pain characterized by allodynia and/or spontaneous pain. It has been suggested that activation of mitogen-activated protein kinases such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal (JNK) contribute to the pain.We investigated if curcumin could prevent development rats with constriction (CCI) sciatic nerve.The animals were divided into 3 groups. In treatment group (n = 10), (50 mg/kg/d PO) was administered once...

Objective Accurate measurement of pelvic floor muscle (PFM) strength is crucial for the management disorders. However, current methods are invasive, uncomfortable, and lack standardization. This study aimed to introduce a novel noninvasive approach precise PFM quantification by leveraging extracorporeal surface perineal pressure (ESPP) measurements machine learning algorithms. Methods Twenty-one healthy women participated in this study. ESPP were obtained using 10 × array sensor during...

Clinical application of the cartilage formed by tissue engineering is not practical due to failure maintain long-term structural integrity. One important factors for maintaining integrity biomaterial a scaffold. The purpose current study was evaluate difference between poly-lactic glycolic acid (PLGA) and chitosan as scaffolds. Human auricular chondrocytes were used. Chondrocyte-scaffold complexes implanted in nude mice analyzed at 4, 8, 12, 16, 24 weeks after implantation. volume...

Background: An emerging theme in the study of pathophysiology persistent pain is role reactive oxygen species (ROS). In present study, we examined hypothesis that exogenous supply antioxidant drugs during peri‐reperfusion would attenuate induced by ischemia/reperfusion (IR) injury. We investigated analgesic effects three antioxidants administered using an animal model complex regional syndrome‐type I consisting chronic post‐ischemia (CPIP) hind paw. Methods: Application a tight‐fitting...

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a member of the CC chemokine family that exhibits potent chemotactic activity for monocytes/macrophages. In current study, proportion monocyte protein-1-immunoreactive (IR) neurons in dorsal root ganglion (DRG) rats was shown to increase markedly following adjuvant injection into hindpaw. MCP-1-IR axon terminals were not found spinal cord or hindpaw control adjuvant-treated rats. Instead, inflamed dermis infiltrated by numerous inflammatory...

Objective To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery. Study Design A prospective, randomized, double‐blind, placebo‐controlled study. Subjects and Methods Ninety women patients undergoing surgery with general anesthesia received intravenously either 0.075 mg/kg or normal saline (n = 45 each) induction anesthesia. The incidence severity postoperative nausea vomiting, rescue antiemetics, pain intensity, side effects such as headache, dizziness,...

Postherpetic neuralgia (PHN) is a serious complication resulting from herpes zoster infections, and it can impair the quality of life. In order to relieve pain PHN, various treatments, including pharmacological interventional methods have been used. However, little information on recommendations for treatment along with lack nation-wide surveys current status PHN exists. This multicenter study first survey in Korea.Retrospective chart reviews were conducted entire patients who visited...

Objective Although curcumin has a protective effect on bone remodeling, appropriate therapeutic concentrations of are not well known as drugs for osteoporosis. The purpose this study was to compare the sparing treatment low-dose and high-dose after ovariectomy in rats. Methods Forty female Sprague-Dawley rats underwent either sham operation (the group) or bilateral (OVX). ovariectomized animals were randomly distributed among three groups; untreated OVX group, (10 mg/kg) administered (50...

Using the Korean Society of Anesthesiologists database anesthesia-related medical disputes (July 2009-June 2014), causative mechanisms and injury patterns were analyzed. In total, 105 cases Most patients aged < 60 yr (82.9%) classified as American physical status ≤ II (90.5%). 42.9% all cases, injuries determined to be 'avoidable' if appropriate standard care had been applied. Sedation was sec most common type anesthesia (37.1% cases), following by general anesthesia. sedation (27/39, 69.2%)...

The purpose of this study was investigating the effects curcumin on histological changes and functional recovery following spinal cord injury (SCI) in a rat model. Following either sham operation or SCI, 36 male Sprague–Dawley rats were distributed into three groups: group, curcumin-treated vehicle-injected group. Locomotor function assessed according to Basso, Beattie, Bresnahan (BBB) scale who had received daily intraperitoneal injections 200 mg/kg an equivalent volume vehicle for 7 days...

Abstract We investigated the therapeutic potential of mouse ESC-derived gamma-amino butyric acid (GABA)ergic neurons (∼74% total in vitro) to reduce neuropathic pain following spinal cord injury (SCI) rats. Spinal hemisection at T13 segment, which is used as a rat SCI model, induced tactile hypersensitivity hind paw, evidenced by decreased paw withdrawal thresholds response von Frey filaments, and also hyperexcitability wide dynamic range lumbar natural cutaneous stimuli. At 2 weeks...

Herpes zoster as a result of reactivated varicella-zoster virus is characterized by vesicular eruptions on skin and painful neuralgia in the dermatome distribution. Pain during an acute phase herpes has been associated with higher risk developing postherpetic neuralgia. The current therapies for including analgesics sympathetic nerve block well antiviral agents are important to alleviate pain prevent However, some cases, does not respond these treatments. We had case which patient did...