A5075504248- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Cerebrovascular and Carotid Artery Diseases
- Neuroblastoma Research and Treatments
- Case Reports on Hematomas
- Cerebral Venous Sinus Thrombosis
- Ear and Head Tumors
- Cellular Mechanics and Interactions
- Management of metastatic bone disease
- Spinal Dysraphism and Malformations
- Venous Thromboembolism Diagnosis and Management
Kyungpook National University
2013-2025
Kongju National University
2024
Kyungpook National University Hospital
2013-2023
Emory University
2021
University of Michigan
2020
Research Center for Applied Science, Academia Sinica
2016
Korea Aerospace Research Institute
2013
Kumoh National Institute of Technology
2012
Dongguk University
2011
Hospital for Sick Children
2002-2008
A 65nm generation logic technology with 1.2nm physical gate oxide, 35nm length, enhanced channel strain, NiSi, 8 layers of Cu interconnect, and low-k ILD for dense high performance is presented. Transistor length scaled down to while not scaling the oxide as a means improve reduce power. Increased NMOS PMOS drive currents are achieved by strain junction engineering. 193nm lithography along APSM mask used on critical provide aggressive design rules 6-T SRAM cell size 0.57/spl mu/m/sup 2/....
Sphingosine 1-phosphate is a bioactive sphingolipid that regulates cell growth and suppresses programmed death. The biosynthesis of sphingosine catalyzed by kinase (SK) but the mechanism which subcellular localization activity SK regulated in response to various stimuli not fully understood. To elucidate origin structural determinant specific SK, we performed biophysical studies human SK1 (hSK1) selected mutants. In vitro measurements showed hSK1 selectively bound phosphatidylserine over...
Malignant glioma is the most common primary brain tumor, and its ability to invade surrounding parenchyma a leading cause of tumor recurrence treatment failure. Whereas molecular mechanisms invasion are incompletely understood, there growing evidence that cytoskeletal-matrix interactions contribute this process. Fascin, an actin-bundling protein, induces parallel actin bundles in cell protrusions increases motility multiple human malignancies. The role fascin remains unclear. We demonstrate...
Abstract Purpose Leptomeningeal metastasis (LM)-associated hydrocephalus is a rare but severe complication of non-small cell lung cancer (NSCLC). The spread malignant cells to the leptomeninges obstructs cerebrospinal fluid flow and increases intracranial pressure (ICP). This study compared outcomes lumboperitoneal (LP) ventriculoperitoneal (VP) shunt surgeries in managing LM-associated hydrocephalus, focusing on symptom-free periods (SFPs) overall survival (OS). Methods A retrospective...
We introduce the concept of a switching strategy for mechanical thrombectomy with period-to-period analysis. In period 1, forced arterial suction Penumbra reperfusion catheter was performed, even in difficult cases; 2, initially to Solitaire cases.We analyzed 135 consecutive patients treated acute large vessel occlusion anterior circulation, 61 from 1 and 74 2. defined case both periods as ≥3 failed attempts at recanalization.Period 2 showed trend better angiographic outcome Thrombolysis...
Ventriculoperitoneal (VP) shunt complication is a major obstacle in the management of hydrocephalus. To study differences VP complications between children and adults, we analyzed revision surgery performed at our hospital during past 10 years.Patients who had undergone from January 2001 to December 2010 were evaluated retrospectively by chart review about age distribution, etiology hydrocephalus, causes revision. Patients grouped into below above 20 years old.Among 528 cases over years, 146...
Objective : Remote cerebellar hemorrhage (RCH) is one of the rare complications occurring after supratentorial surgery, and its pathomechanism poorly understood.We report 10 cases RCH from our institution review 154 a database in order to delineate incidence, common presentation, risk factors, outcomes this complication.In addition, means prevention are discussed.Methods We reviewed medical records patients who experienced undergoing surgery at between 2001 2008.A search Medline revealed...
Objective : Pituitary apoplexy (PA) is described as a clinical syndrome characterized by sudden headache, vomiting, visual impairment, and meningismus caused rapid enlargement of pituitary adenoma.We retrospectively analyzed the presentation surgical outcome in PA presenting with cranial neuropathy.Methods Twelve cases (3.3%) were reviewed among 359 patients diagnosed adenoma.The study included 6 males females.Mean age was 49.0 years, range 16 to 74 years.Follow-up duration ranged from 3 20...
The aim of this study was to provide information help confirm the diagnosis trigeminal neuralgia (TN) using MR imaging.The authors evaluated atrophy nerve, cross-sectional area cerebellopontine angle (CPA) cistern, and length cisternal segment nerve on affected side in 26 consecutive patients with TN who were treated Gamma Knife surgery.The mean volume significantly smaller than unaffected (p < 0.001). Nerve present 25 (96.2%) 1 patient side. CPA cistern (188.5 mm2) (232.8 = (7.9 mm) shorter...
The natural compound curcumin was known to inhibit migration and invasion of glioblastoma (GBM) cells. Fascin, a kind actin-binding proteins, is correlated with GBM purpose this study investigate anti-migration anti-invasion effects via suppression fascin expression in cells.U87 cell line used as an experimental model GBM. Fascin quantified by Western blot analysis. And, the signal transducer activator transcription 3 (STAT3), play important role tumor cells, were analyzed sandwich-ELISA....
Objective Although curcumin has a protective effect on bone remodeling, appropriate therapeutic concentrations of are not well known as drugs for osteoporosis. The purpose this study was to compare the sparing treatment low-dose and high-dose after ovariectomy in rats. Methods Forty female Sprague-Dawley rats underwent either sham operation (the group) or bilateral (OVX). ovariectomized animals were randomly distributed among three groups; untreated OVX group, (10 mg/kg) administered (50...
The purpose of this study was investigating the effects curcumin on histological changes and functional recovery following spinal cord injury (SCI) in a rat model. Following either sham operation or SCI, 36 male Sprague–Dawley rats were distributed into three groups: group, curcumin-treated vehicle-injected group. Locomotor function assessed according to Basso, Beattie, Bresnahan (BBB) scale who had received daily intraperitoneal injections 200 mg/kg an equivalent volume vehicle for 7 days...
Abstract The generation of contractile force mediated by actin‐myosin interactions is essential for cell motility. Myosin activity promoted phosphorylation myosin light chain (MLC). MLC in large part controlled kinases that are effectors Rho family GTPases. Accordingly, this study we examined the effects ROCK and Rac1 inhibition on astrocytoma cells. We found low concentrations inhibitor Y27632 increased state Triton X‐100 soluble fraction MLC, whereas higher decreased phospho‐MLC. These...
Immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis, defined as focally or diffusely thickened dura mater and lymphoplasmacytic infiltration with increased IgG4 bearing plasma cells, is a rare disease. Moreover, cases involving bone are even rarer. In this report, the authors describe case of IgG4-related pachymeningitis skull in 65-year-old man presenting generalized tonic seizures. There 2.4 cm diameter extra-axial mass at vertex left frontal convexity contrast enhancement on...
The authors describe 9 cases of children with eosinophilic granuloma (EG) the skull and report on their clinical manifestations, treatment, prognosis.Nine consecutive patients were diagnosed as EG confirmed pathologically between 1996 2005. In present study, multi- single-system Langerhans' cell histiocytosis without involvement excluded. Patients divided into two groups: (1) those only a single bone lesion (2) multiple lesions. Surgical removal was performed 2 10 years age (mean, 4.2...
Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma the central nervous system, which arises from melanocytes within leptomeninges and carries poor prognosis.We report case in 17-year-old man, was diagnosed with 18 F-fluorodeoxyglucose (F-18 FDG) PET/CT, post hoc F-18 FDG PET/MRI fusion images.Whole-body PET/CT helpful ruling out extracranial origin lesions, assessing therapeutic response.Post images facilitated correlation between PET MRI demonstrated...
Case Report of the Surgical ExperienceIntramedullary spinal cord metastasis (ISCM) from renal cell carcinoma (RCC) is rare manifestation and most them are treated by adjuvant treatment modalities like radiotherapy.Despite radio-resistance RCC itself, focal radiotherapy has been preferred as first-line modality ISCM only a few cases underwent surgical treatment.We describe case RCC, which excision pathologically confirmed.A 44-yr-old man was presented with rapid deterioration motor weakness...