A5025687141- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Tuberculosis Research and Epidemiology
- Hormonal Regulation and Hypertension
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Inflammatory Myopathies and Dermatomyositis
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Smart Agriculture and AI
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Histone Deacetylase Inhibitors Research
- Parathyroid Disorders and Treatments
- Endometriosis Research and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Ion Transport and Channel Regulation
Henry Ford Hospital
2023-2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2014-2024
Translational Health Science and Technology Institute
2023-2024
Henry Ford Health System
2024
Galgotias University
2022-2024
Indian Institute of Management Rohtak
2024
Jawaharlal Nehru Medical College
2023
Cancer Institute (WIA)
2023
Amity University
2022
Artificial Intelligence in Medicine (Canada)
2022
Triple-negative breast cancer (TNBC), as one of the most aggressive forms cancer, is characterized by a poor prognosis and very low rate disease-free overall survival. In recent years, immunotherapeutic approaches targeting T cell checkpoint molecules, such cytotoxic lymphocyte antigen-4 (CTLA-4), programmed death1 (PD-1) or its ligand, death ligand 1 (PD-L1), have shown great potential been used to treat various cancers single therapies in combination with other modalities. However, despite...
In various cancer models, dietary interventions have been shown to inhibit tumor growth, improve anticancer drug efficacy, and enhance immunity, but no such evidence exists for epithelial ovarian (EOC), the most lethal gynecologic cancer. The immune responses induced by 16-h intermittent fasting (IF) were studied in mice with EOC. IF consistently reduced metabolic growth factors cytokines that stimulate creating a tumor-hostile environment. Immune profiling showed dramatically alters...
Abstract Background Release of 5‐hydroxytryptamine (5‐ HT ; serotonin) from activated platelets following microvascular injury leads to tissue fibrosis. 5‐ strongly induces extracellular matrix synthesis in dermal fibroblasts a transforming growth factor beta 1 ( TGF ‐β1)‐dependent manner. Aim To evaluate anti‐fibrotic properties inhibitors 2 and 2B (terguride, SB 204741) respectively human adult HADF ) derived patient with scleroderma. Methods Anti‐fibrotic efficacy was evaluated as per two...
Epithelial Ovarian Cancer (EOC) is the most lethal gynecologic cancer with limited genetic alterations identified that can be therapeutically targeted. In tumor bearing mice, short-term fasting, fasting mimicking diet and calorie restriction enhance activity of antineoplastic treatment by modulating systemic metabolism boosting anti-tumor immunity. We tested outcome sixteen-hour intermittent (IF) on mouse EOC progression focus driven antitumor immune responses. IF resulted in consistent...
Purpose This study systematically reviews the existing literature on application of gamification in logistics and supply chain management (LSCM). aims to categorise various domains, conceptualise framework pertinent context LSCM provide a research agenda for scholars area. Design/methodology/approach The study’s methodology adopts Preferred Reporting Items Systematic Review Meta-Analysis conduct systematic review. Forty relevant papers published from 2012 2023 are included analysis. Findings...
Context: Clinical, endoscopic, radiological and histological parameters of intestinal tuberculosis (IT) Crohn's disease (CD) are so similar that differentiation between these two diseases, which require different treatment, is difficult. Anti- Saccharomyces cerevisiae antibody (ASCA), often present in the sera patients with CD, may be potentially useful to differentiate CD from IT. Aim: To evaluate role enzyme-linked immunosorbent assay test for ASCA serum differentiating tuberculosis....
Introduction: Peritoneal fibrosis (PF) results in technique failure peritoneal dialysis (PD) patients. fibroblasts are characterized by increase the ACTA2 gene, responsible for alpha smooth muscle actin (α−SΜΑ), extracellular matrix (ECM) production, and inflammatory cytokines which key mediators pathogenesis of PF. 5-hydroxytryptamine (5-HT; serotonin) induces ECM synthesis a transforming growth factor-beta 1 (TGF-β1) dependent manner. The purpose our study was to identify potential...
High-resolution 1H-NMR spectroscopy of serum and urine samples an 11-year-old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous excretion urinary post-transplantation. High in both blood concomitant reduced urea were found be evidence impairment cycle compatible persistently graft function. Thus urine, the as observed by highlight their important roles monitoring function; lead brain damage, if untreated.
Background: Reduced HDACs levels have been reported in steroid resistant chronic obstructive pulmonary disease and bronchial asthma patients. P-glycoprotein (P-gp) over expression peripheral blood mononuclear cells (PBMCs) has patients with nephrotic syndrome (NS). Whether how P-gp are linked each other is not clear, especially NS Aim: To evaluate mRNA of P-gp/MRP-1 HDAC2 PBMCs sensitive (SSNS) (SRNS) patients, determine the relationship between P-gp/ MRP-1in Methods: Twenty subjects (10...
The quality of platelet concentrates (PC) is an important issue in transfusion therapy. Recently, indices have been used as markers for the control PCs, these reflect storage-induced shape changes platelets. We also analyzed such count, which could be detrimental and influence rate pH change during acceptable storage conditions. In present study, (with without EDTA) were stored PC. Forty pooled PRP-PCs 7 days various with EDTA incubation. These included count (PLT), mean volume (MPV),...
With the advancement of AI technology, generation content has become easier and more accessible. In such a scenario, it is difficult to differentiate between human-generated text AI-generated text. To address this concern, our methodology proposes an intelligent system capable analyzing files classifying unique writing styles using stylometric analysis. This work also compares various clustering algorithms, including k-means, k-means++, hierarchical, DBSCAN, utilizing silhouette scores as...
In horticulture and agriculture, classification intelligent identification of disease is the need hour. Apple one most cultivated consumed fruit in world. It a nutritious that contains vitamin A, B1, B12, folic acid. can even keep doctors away. The same susceptible to various diseases such as blotch nematode, leading social economic losses. This paper proposes diseased healthy apples using deep learning technique. A dataset 570 images 3 (Blotch, Rot, Scab) are used model along with normal...
Neutrophil CD64 (nCD64) has been found to identify sepsis from nonseptic patients. It is also reported be a predictor of survival and severity sepsis. The goal this study was correlate serial nCD64 with Intensive Care Unit (ICU) outcome sepsis.A prospective observational conducted in 12-bedded critical care unit tertiary center. Adult patients were included study. Demographics, illness scores, clinical parameters, laboratory data, 28-day recorded. Serial analysis done (on days 0, 4, 8)...
Abstract To assess utility of neutrophilCD64 (nCD64) expression in differentiating bacterial infection from inflammation patients with severe alcoholic hepatitis (SAH) fulfilling systemic inflammatory response syndrome criteria. Patients SAH and (n = 58), without 70), healthy controls 20) were included. Neutrophil CD64 by flowcytometry, serum Procalcitonin (ELISA) C-reactive protein (Nephelometry) neutrophil–lymphocyte ratio (NLR) studied. Percentage neutrophils (nCD64%) was significantly...
Introduction: Resistance to corticosteroid is an essential mechanism in uncontrolled asthma as the mainstay of therapy. There are recent reports that epigenetic factors play a crucial role regulation steroid action. Overexpression P glycoprotein (P-gp) and reduced expression Histone Deacetylase 2 (HDAC2) have been linked regulating action other diseases like Nephrotic Syndrome (NS). However, their still not clear warrants further investigation. We evaluated activity P-gp HDAC2 patients with...
Medical Laboratory Science (MLS) is a vital component of the health care system that provides diagnostic services and contributes to medical research. In India, MLS has been evolving rapidly in terms technology, education, regulation, quality. This paper aims provide comprehensive overview current status future prospects with focus on challenges opportunities faced by professionals stakeholders involved this field. The historical development scope India described, highlighting various roles...