A5089610978- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
- Plant biochemistry and biosynthesis
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Oral and Maxillofacial Pathology
- Anesthesia and Sedative Agents
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Tumors and Oncological Cases
- Virus-based gene therapy research
- Prostate Cancer Treatment and Research
- Phytochemicals and Medicinal Plants
- Immune Cell Function and Interaction
- Veterinary Pharmacology and Anesthesia
- Bone Tumor Diagnosis and Treatments
- Plant tissue culture and regeneration
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Systemic Lupus Erythematosus Research
- PI3K/AKT/mTOR signaling in cancer
- Drug-Induced Hepatotoxicity and Protection
- Transgenic Plants and Applications
- Alzheimer's disease research and treatments
- RNA modifications and cancer
Indian Institute of Integrative Medicine
2017-2025
Malaviya National Institute of Technology Jaipur
2025
All India Institute of Medical Sciences
2022-2024
Virginia Commonwealth University
2021-2024
Teerthanker Mahaveer University
2024
Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya
2014-2024
Rajasthan University of Veterinary and Animal Sciences
2023-2024
Johns Hopkins Medicine
2018-2023
Johns Hopkins University
2018-2023
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2022-2023
Lysine acetylation is a posttranslational modification that dynamically regulated by the activity of acetyltransferases and deacetylases. The human mouse genomes encode 18 different lysine deacetylases (KDACs) which are key regulators many cellular processes. Identifying substrates KDACs pinpointing sites on target proteins may provide important information about molecular basis their functions. Here we apply quantitative proteomics to identify endogenous mitochondrial deacetylase Sirtuin 3...
Crocus sativus is the only plant species which produces apocarotenoids like crocin, picrocrocin and safranal in significant amounts. These compounds impart organoleptic properties to saffron (dried stigmas of flower) making it world's costliest spice. have tremendous medicinal as well. Effect endophytes on apocarotenoid production molecular mechanism involved has not been reported so far. Here we studied effect an oleaginous fungal endophyte, Mortierella alpina CS10E4 growth, metabolism...
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein depletes Tregs, was approved for the treatment of cell malignancies, but its clinical use limited due to presence aggregates toxicity associated with vascular leakage. Here, we report production second-generation IL-2 receptor-targeted, fully-folded, monomeric diphtheria...
Cells have evolved their communication methods to sense microenvironments and send biological signals. In addition using ligands receptors, cells use diverse channels including gap junctions communicate with immediate neighbors. Current approaches, however, cannot effectively capture the influence of various microenvironments. Here, we propose a novel approach investigate cell neighbor-dependent gene expression (CellNeighborEX) in spatial transcriptomics (ST) data. To categorize based on...
Selected medicinal plants possess many phytochemicals that have excellent antioxidant and anti-cell proliferation potential. The banana stem extract (BSE) is also one among them which therapeutic values. objective of the current experiment was to identify confirm activity using suitable validated in-vitro experiments. Banana prepared by traditional extraction method. presence various classes were confirmed qualitative phytochemical screening tests a standard protocol. BSE subjected cell...
The present work employs the CCSD(T)/CBS//M06-2X/aug-cc-pVTZ level of theory to investigate effect a water monomer (WM) and dimer (WD) on oxidation nitrous acid (HONO) by Criegee intermediate (CH 2 OO).
Abstract The wonder drug artemisinin, a sesquiterpene lactone endoperoxide from Artemisia annua is the million‐dollar molecule required to curb deadliest disease, Malaria. One of major challenges even today increase concentration artemisinin within plants. transcription factors are important regulators plant secondary metabolites and have potential regulate key steps or whole biosynthetic pathway. In this study, we identified characterised two bHLH ( Aa6119 Aa7162 ) A. . Both turned out be...
CYP2E1 plays a crucial role in the bio-activation of toxic substances leading to liver damage. In this context, converts paracetamol (PCM) N-acetyl-p-benzoquinone imine (NAPQI), which is prone cause hepatotoxicity. Hence, we aimed explore protective effect glabridin on widely used PCM-induced injury model present study and, after that, correlated with toward its efficacy. Glabridin was isolated from Glycyrrhiza glabra and characterized before investigation an in-vivo mice injury. oral...
Bone metastasis is a frequent and incurable consequence of advanced prostate cancer (PC). An interplay between disseminated tumor cells heterogeneous bone resident in the metastatic niche initiates this process. Melanoma differentiation associated gene-9 ( mda-9/Syntenin/syndecan binding protein ) prometastatic gene expressed multiple organs, including marrow–derived mesenchymal stromal (BM-MSCs), under both physiological pathological conditions. We demonstrate that PDGF-AA secreted by...
The Kaposi's sarcoma-associated herpesvirus infects the human population and maintains latency stage of viral life cycle in a variety cell types including cells epithelial, mesenchymal endothelial origin. establishment latent infection by KSHV requires expression an unique repertoire genes among which associated nuclear antigen (LANA) plays critical role replication genome. LANA regulates transcription number cellular essential for survival virus host cell. present study demonstrates...