A5103119249- Hippo pathway signaling and YAP/TAZ
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Phagocytosis and Immune Regulation
- Virus-based gene therapy research
- Neuropeptides and Animal Physiology
- Ginger and Zingiberaceae research
- CAR-T cell therapy research
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Garlic and Onion Studies
- Immune Cell Function and Interaction
- Cardiac Ischemia and Reperfusion
- Axon Guidance and Neuronal Signaling
- Autism Spectrum Disorder Research
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Cholinesterase and Neurodegenerative Diseases
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Fatty Acid Research and Health
Virginia Commonwealth University
2013-2024
Virginia Commonwealth University Medical Center
2023
Medical University of South Carolina
2010-2013
The University of Texas Health Science Center at San Antonio
2012
Annamalai University
2003-2008
Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The transporter (SERT) gene ( SLC6A4 ) has been associated with whole blood levels and ASD susceptibility. Previously, we identified multiple gain-of-function SERT coding variants in children ASD. Here establish that transgenic mice expressing the most common of these variants, Ala56, exhibit elevated, p38 MAPK-dependent phosphorylation,...
Abstract Melanoma Differentiation Associated Gene-7/Interleukin-24 (IL-24) and IL-15 provide therapeutic benefit in treating specific cancers. IL-24 displays cancer-specific apoptosis/toxic autophagy-inducing properties a broad spectrum of human tumors without harming normal cells. induces both differentiation proliferation T lymphocyte (T) natural killer (NK) cells, enhances the cytolytic activity CD8+ maturation dendritic cells (DCs). In vivo administration has antitumor effects several...
Brain-derived neurotrophic factor (BDNF) is critical in synaptic plasticity and the survival function of midbrain dopamine neurons. In this study, we assessed effects a partial genetic deletion BDNF on motor (DA) neurotransmitter measures by comparing Bdnf(+/-) with wildtype mice (WT) at different ages. WT had similar body weights until 12 months age; however, 21 months, were significantly heavier than mice. Horizontal vertical activity was reduced for compared to mice, but not influenced...
Melanoma differentiation associated gene-9 (MDA-9), Syntenin-1, or syndecan binding protein is a differentially regulated prometastatic gene with elevated expression in advanced stages of melanoma. MDA-9/Syntenin positively associates disease stage multiple histologically distinct cancers and negatively correlates patient survival response to chemotherapy. highly conserved PDZ-domain scaffold protein, robustly expressed spectrum diverse cancer cell lines clinical samples. PDZ domains...
The serotonin (5-HT) transporter (SERT) regulates serotoninergic neurotransmission by clearing 5-HT released into the synaptic space. Phosphorylation of SERT on serine and threonine mediates regulation. Whether tyrosine phosphorylation is unknown. Here, we tested hypothesis that tyrosine-phosphorylation transport. In support this, alkali-resistant <sup>32</sup>P-labeled was found in rat platelets, Src-tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(<i>t</i>-butyl)pyrazolo...
Bone metastasis is a frequent and incurable consequence of advanced prostate cancer (PC). An interplay between disseminated tumor cells heterogeneous bone resident in the metastatic niche initiates this process. Melanoma differentiation associated gene-9 ( mda-9/Syntenin/syndecan binding protein ) prometastatic gene expressed multiple organs, including marrow–derived mesenchymal stromal (BM-MSCs), under both physiological pathological conditions. We demonstrate that PDGF-AA secreted by...
The norepinephrine (NE) transporter (NET) regulates NE signaling by rapidly clearing synaptic NE. Cocaine binds NET and modulates transport. These actions contribute to rewarding effects abuse liability of cocaine. Activation mitogen-activated protein kinase (MAPK) cascades is implicated in cocaine-induced neuroadaptations. However, the role MAPK mechanisms involved cocaine modulation are not clear. Acute intra-peritoneal injections (20 mg/kg body weight) rats resulted increased uptake...
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer without effective therapies and with poor prognosis, causing 7% of all cancer-related fatalities in the USA. Considering lack for this cancer, there urgent need to define newer more therapeutic strategies. Polyinosine–polycytidylic acid (pIC) a synthetic double-stranded RNA (dsRNA) which directly activates dendritic cells natural killer inhibiting tumor growth. When pIC delivered into cytoplasm using polyethyleneimine...
Abstract Primary, glioblastoma, and secondary brain tumors, from metastases outside the brain, are among most aggressive therapeutically resistant cancers. A physiological barrier protecting blood–brain (BBB), functions as a deterrent to effective therapies. To enhance cancer therapy, we developed terminator virus ( CTV ), unique tropism‐modified adenovirus consisting of serotype 3 fiber knob on an otherwise Ad5 capsid that replicates in cancer‐selective manner simultaneously produces potent...
D-amphetamine (AMPH) down-regulates the norepinephrine transporter (NET), although exact trafficking pathways altered and motifs involved are not known. Therefore, we examined cellular molecular mechanisms in AMPH-induced NET regulation human placental trophoblast cells expressing wild-type (WT)-hNET hNET double mutant (DM)-bearing protein kinase C (PKC)-resistant T258A + S259A motif. function surface expression were significantly reduced WT-hNET but hNET-DM following AMPH treatment....
Abstract: This study was aimed to evaluate the preventive role of S‐allylcysteine (SAC) on creatine kinase‐MB, iron, iron binding capacity, uric acid, total protein, membrane‐bound enzymes such as sodium potassium‐dependent adenosine triphosphatase, calcium‐dependent triphosphatase and magnesium‐dependent glycoproteins hexose, hexosamine, fucose sialic acid in isoproterenol‐induced myocardial infarction rats. Male albino Wistar rats were pre‐treated with SAC (50, 100 150 mg/kg) daily for a...
Abstract Genome-wide gene expression analysis and animal modeling indicate that melanoma differentiation associated gene-9 (mda-9, Syntenin, Syndecan binding protein, referred to as MDA-9/Syntenin) positively regulates metastasis. The MDA-9/Syntenin protein contains two tandem PDZ domains serving a nexus for interactions with multiple proteins initiate transcription of metastasis-associated genes. Although targeting either domain abrogates signaling prometastatic phenotypes, the integrity...
Abstract The present study evaluates the effect of S ‐allylcysteine on marker enzymes, serum and myocardial lipids in normal isoproterenol‐induced infarction male Wistar rats. A significant increase activities enzymes such as creatine kinase, lactate dehydrogenase, aspartate transaminase alanine isoproterenol (150 mg kg −1 )‐treated rats was observed. levels (cholesterol, triglycerides, free fatty acids phospholipids) were significantly increased, while cholesterol, triglycerides increased...