A5090790474- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Peripheral Artery Disease Management
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Vascular anomalies and interventions
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Vascular Malformations and Hemangiomas
- Medical Imaging and Pathology Studies
- Ultrasound and Hyperthermia Applications
- Coronary Interventions and Diagnostics
- Cancer Immunotherapy and Biomarkers
Singapore General Hospital
2015-2024
Duke-NUS Medical School
2018-2024
Society of Interventional Radiology
2023
Sengkang General Hospital
2021-2022
KK Women's and Children's Hospital
2022
A*STAR Graduate Academy
2016-2020
National University Hospital
2020
National University of Singapore
2018-2019
Mount Elizabeth Hospital
2018
Hillrom (Singapore)
2018
Mesenchymal epithelial transition factor ( MET) activation has been implicated as an oncogenic driver in epidermal growth receptor EGFR)-mutant non-small-cell lung cancer (NSCLC) and can mediate primary secondary resistance to EGFR tyrosine kinase inhibitors (TKI). High copy number thresholds have suggested enrich for response MET inhibitors. We examined the clinical relevance of gain (CNG) setting treatment-naive metastatic EGFR-mutant-positive NSCLC.
Purpose To compare lesion primary patency and restenosis rates between drug-eluting balloon (DEB) percutaneous transluminal angioplasty (PTA) conventional PTA (cPTA) in the treatment of arteriovenous fistula (AVF) graft (AVG) stenosis. Materials Methods In this prospective study, 119 participants (mean age, 59.2 years; 79 men, 40 women) with failing AVFs (n = 98) or AVGs 21) were randomly assigned to undergo either DEB 59) cPTA 60) from January 2012 May 2013. Primary end points at 6 months;...
Hepatocellular carcinoma (HCC) is the 6th most common cancer in world, but second cause of death. There no universally accepted consensus practice guidelines for HCC owing to rapid developments new treatment modalities, heterogeneous epidemiology and clinical presentation worldwide. However, a number regional national currently exist which reflect relevant collective experience group. In 2014, clinicians at multidisciplinary Comprehensive Liver Cancer Clinic (CLCC) National Centre Singapore...
4590 Background: Nivolumab (N) and Y90-radioembolization (RE) are both therapeutic options in advanced hepatocellular carcinoma (aHCC). Increasing evidence suggests that radiotherapy synergizes with immune checkpoint inhibitors to augment anti-tumour effects. Methods: Eligible Child-Pugh A aHCC patients (pts) were treated Y90-RE followed by N 240mg, 21 days after every 2 weeks thereafter. Pre- on-treatment tumor biopsies together circulating biomarkers obtained. Primary end-point was overall...
Background There is a paucity of randomized trials demonstrating superior efficacy drug-coated balloon angioplasty (DCBA) compared with conventional percutaneous transluminal (PTA) for below-the-knee arterial disease in patients critical limb ischemia. Purpose To compare DCBA versus PTA lesions participants critical ischemia through 12 months. Materials and Methods In this prospective, randomized, two-center, double-blind superiority study, rest pain or tissue loss atherosclerotic the...
Dense breasts are common in Asian women and they limit the sensitivity of mammography. This study evaluates performance supplementary breast ultrasound screening with dense mammograms.The was approved by hospital's Institutional Review Board. A prospective clinical trial performed between September 2002 November 2004. Asymptomatic negative mammograms were offered for cancer. Ultrasound assessment categorised as U1 to U4. U2 cases recommended routine interval U3 follow-up 6 months mammography...
With astonishing speed, COVID-19 has become a global pandemic. As it is uncertain when the pandemic will be controlled, crucial for procedurists of all stripes to familiar and confident in performing procedures patients prevent intra-hospital infection. In this article, we detail our approach on how perform interventional at bedside isolation room with patient transferred radiology centre. These workflows have been developed conjunction multiple other stakeholders within hospital, drawing...
Abstract Purpose: Despite the established role of EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC, drug resistance inevitably ensues, with a paucity treatment options especially EGFRT790M-negative resistance. Experimental Design: We performed whole-exome and transcriptome analysis 59 patients first- second-generation TKI-resistant metastatic NSCLC to characterize compare molecular alterations mediating T790M-positive (T790M+) -negative (T790M−) disease. Results: Transcriptomic...
History A 70-year-old man presented to the emergency department with fever, chills, rigors, and upper abdominal discomfort. Physical examination revealed jaundice mild right quadrant tenderness. Laboratory tests an increased C-reactive protein level of 133 mg/L (normal range, 0.2–0.9 mg/L), a white blood cell count 11.69 ×109/L 4–10 ×109/L), obstructive pattern on liver function tests, total bilirubin 3.5 mg/dL (59.9 µmol/L) 0.4–1.9 [6.8–32.5 µmol/L]), alkaline phosphatase 716 U/L (11.9...
8107 Background: Overcoming EGFR TKI resistance (R) is a major clinical challenge; reported mechanisms include T790M mutation (mt), MET amplification (amp) and PIK3CA mt. As the PI3K pathway central convergent signaling node, we hypothesized that addition of buparlisib (BKM) could overcome TKI-R. Methods: Patients (pt) resistant to (Jackman JCO 2010) were enrolled determine safety, tolerability, pharmacokinetics (PK) pharmacodynamics BKM-gef. Using “3+3” design, escalating doses BKM added pt...
Severe acute respiratory syndrome (SARS) was a highly virulent atypical pneumonia caused by novel coronavirus that resulted in pandemic 2003. Singapore one of the most severely affected countries, and SARS took heavy toll on our health care system. The lessons learned during have shaped national contagion response plan proved valuable subsequent epidemics. We describe for radiology department.Our experience with has changed daily practice radiology.
Hepatic venous pressure gradient (HVPG) is the gold-standard for measurement of portal hypertension, a common cause life-threatening conditions such as variceal bleeding and hepatic encephalopathy. HVPG also plays crucial role in risk stratification, treatment selection assessment response. Thus recognition pitfalls unusual crucial. This article aims to provide radiographical clinical guide with representative cases.
Background: Percutaneous pharmacomechanical thrombolysis is increasingly used to salvage thrombosed hemodialysis access. We aim evaluate the effectiveness of alteplase compared urokinase in percutaneous clotted Methods: Records patients who underwent at Interventional Nephrology Suite a tertiary teaching hospital from 1 January 2016 31 December were reviewed. Technical and clinical success rates, thrombosis-free cumulative survivals, procedure time, radiation dose imparted for with versus...
This study aimed to report the outcomes of endovascular salvage clotted arteriovenous (AV) accesses and determine potential predictors poor patency rates after thrombectomy.Records hemodialysis patients who underwent AV access were reviewed retrospectively. Technical clinical success rates, complication 3- 6-month determined. Multivariate analysis was performed thrombectomy.A total 294 during period; 156 had fistula, whereas remaining 138 grafts (AVGs). The technical 96.3% 93.2%; major minor...