A5015762063- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Protease and Inhibitor Mechanisms
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Obstructive Sleep Apnea Research
- COVID-19 Clinical Research Studies
- Cardiovascular and Diving-Related Complications
- Occupational and environmental lung diseases
- Neurogenetic and Muscular Disorders Research
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Airway Management and Intubation Techniques
- Peptidase Inhibition and Analysis
- Viral Infections and Immunology Research
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
University of Padua
2012-2025
Azienda Ospedaliera di Padova
2007-2020
University of Ferrara
1999-2007
University of Modena and Reggio Emilia
2006
Imperial College London
2006
St. Joseph’s Healthcare Hamilton
2002
McMaster University
2002
Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes health care costs mostly related to hospitalization. The role infections in COPD is controversial.We investigated whether requiring hospitalization associated with viral and/or bacterial infection and evaluated relationships among infection, exacerbation severity, assessed by reduction FEV1, specific patterns airway inflammation.We examined 64 patients when hospitalized for exacerbations, stable...
Previous studies have shown an increased number of inflammatory cells and, in particular, CD8 + ve the airways smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar process is also present lungs, and particularly lung parenchyma arteries. We examined surgical specimens from three groups subjects undergoing resection for localized lesions: nonsmokers (n = 8), asymptomatic normal function 6), COPD 10). Alveolar walls arteries were...
To quantify the number of goblet cells and inflammatory in epithelium peripheral airways smokers with both symptoms chronic bronchitis airflow limitation, we examined surgical specimens obtained from 25 subjects undergoing lung resection for localized pulmonary lesions: 10 six asymptomatic normal function, nine nonsmoking control subjects. Peripheral were histochemical methods to identify immunohistochemical total leukocytes (CD45+ cells), neutrophils, macrophages, CD4+ CD8+ epithelium. When...
We investigated the relationship between reversibility of airflow limitation, concentration nitric oxide (NO) in exhaled air, and inflammatory cells sputum patients with stable chronic obstructive pulmonary disease (COPD). examined nine normal healthy control subjects 20 nonatopic COPD. Ten had no limitation (increase FEV(1) < 12% 200 ml after microg inhaled salbutamol), 10 partial but > salbutamol). Exhaled NO levels were higher COPD than those (median 24 [interquartile range 15.3 to 32]...
Summary Background Near‐fatal asthma (NFA) is characterized by severe attacks usually requiring intensive care unit admission. This phenotype of has been studied mainly in acute conditions. Methods The aim our study was to compare the clinical, functional and inflammatory characteristics NFA patients with mild asthmatics stable We recruited 155 asthmatic from five centres European Network for Understanding Mechanisms Severe Asthma: 67 mild‐to‐moderate controlled low/medium doses inhaled...
Pulmonary fibrosis (PF), a pathological outcome of chronic and acute interstitial lung diseases associated to compromised wound healing, is key component the "post-acute COVID-19 syndrome" that may severely complicate patients' clinical course. Although inconclusive, available data suggest more than third hospitalized patients develop fibrotic abnormalities after their discharge from hospital. The pathogenesis PF in recovering severe case complex, several hypotheses have been formulated...
Background: Patients suffering from idiopathic pulmonary fibrosis (IPF) may experience acute exacerbation (AE-IPF), which frequently results in respiratory failure (ARF) requiring hospitalization. Objective: This study aims to determine if survival has improved over the last decade patients hospitalized for ARF consequent AE-IPF, view of progress recently made pharmacological and supportive treatment strategies. Methods: was an observational retrospective single-center study. The data 14...
The precise locations of neurokinin (NK)-1 and NK-2 receptors in human airways, their role airway inflammatory diseases, have not been carefully examined. To determine the distribution NK-1 central to whether was different smokers, we examined surgical specimens from patients undergoing lung resection for limited lesions. We mapped four groups subjects: asymptomatic nonsmokers, seven symptomatic smokers with normal function, eight chronic airflow limitation. Tissues were immunostained...
Patients with fixed airflow limitation are grouped under the heading of chronic obstructive pulmonary disease (COPD). The authors investigated whether COPD patients have distinct functional, radiological and sputum cells characteristics depending on presence or absence emphysema. Twenty-four outpatients, 12 without emphysema high-resolution computed tomography scan chest, were examined. underwent chest radiography, function tests induction analysis. Subjects documented had lower forced...
Some patients with idiopathic pulmonary fibrosis (IPF) develop acute exacerbation (AE-IPF) leading to severe respiratory failure (ARF); despite conventional supportive therapy, the mortality rate remains extremely high. The aim of this study was assess how a treatment algorithm incorporating high-flow nasal cannula (HFNC) oxygen therapy affects short-term AE-IPF who ARF.A retrospective cohort analysis conducted.The consisted 17 admitted intensive care unit (RICU) for ARF managed using HFNC....
Objective: To examine the effect of pirfenidone on survival patients hospitalized due to acute exacerbation idiopathic pulmonary fibrosis (AE–IPF).Methods: The outcomes 11 consecutive AE–IPF who were receiving treatment when they admitted a respiratory intensive care unit (RICU) for failure (ARF) (treatment group) retrospectively compared with those 9 not at admission (control group). study’s primary outcome measure was following RICU admission; patients’ mortality rate and length time spent...
Objectives: The effect of induction chemotherapy (IC) on lung function and exercise capacity in patients with malignant pleural mesothelioma (MPM) has not been largely examined. aim this study was to evaluate the changes pulmonary oxygen consumption following IC MPM. Methods: Between 2004 2009, 36 consecutive (mean age 62.1 ± 1.5 years, M/F = 25/11) were prospectively investigated. Data concerning medical history, histology, staging response collected. All underwent test before (in absence...
The efficacy and effectiveness of nintedanib as a first-line therapy in idiopathic pulmonary fibrosis (IPF) patients have been demonstrated by clinical trials real-life studies. Our aim was to examine the safety profile when it is utilized second-line treatment subjects who discontinued pirfenidone.The medical charts 12 were switched from pirfenidone examined retrospectively. drug's defined number adverse events (AEs) that reported; disease progression evaluated based on patient's vital...
Background: Patients with COVID-19 may experience hypoxemic Acute Respiratory Failure (hARF) requiring O2-therapy by High-Flow Nasal Cannula (HFNO). Although Prone Positioning (PP) improve oxygenation in non-intubated patients, the results on its clinical efficacy are controversial. The present study aims to prospectively investigate whether PP reduce need for endotracheal intubation (ETI) patients receiving HFNO. Methods: All consecutive unselected adult bilateral lung opacities chest X-ray...
Objectives: The real incidence of pneumomediastinum (PNM) in adult patients with severe acute asthma exacerbation continues to be unknown. current study aims investigate the occurrence PNM an population presenting a attack and evaluate risk factors associated its development. Methods: 45 consecutive subjects who were admitted our Division between January 1, 2015 December 31, 2016 for underwent diagnostic protocol including standard chest X-ray continuous monitoring arterial oxygen saturation...
Abstract Background Despite improvement in lung function, most transplant (LTx) recipients show an unexpectedly reduced exercise capacity that could be explained by persisting peripheral muscle dysfunction of multifactorial origin. We analyzed the course symptoms, including dyspnea, effort and pain its relation with cardiac pulmonary function parameters during incremental testing. Methods Twenty-four bilateral LTx were evaluated observational cross-sectional study. Recruited patients...