A5021046897- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Engineering Applied Research
- Antibiotic Use and Resistance
- Insect symbiosis and bacterial influences
- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Genetics, Bioinformatics, and Biomedical Research
- Plant Virus Research Studies
- Microbial Community Ecology and Physiology
- Plant-Microbe Interactions and Immunity
Yonsei University
2012-2019
Acinetobacter baumannii is an opportunistic pathogen that causes serious nosocomial infection in intensive care units. In particular, carbapenem-resistant A. (CRAB) strains have been increasing the past decade, and they caused major medical problems worldwide. this study, a novel lytic phage, YMC 13/03/R2096 ABA BP (phage Βϕ-R2096), which specifically lysis of CRAB strains, was characterized detail vitro silico, vivo effectiveness phage therapy evaluated using Galleria mellonella mouse model...
Extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) is a life-threatening pathogen that causes serious global problems. Here, we investigated two novel P. bacteriophages (phages), Bϕ-R656 and Bϕ-R1836, in vitro, silico, vivo to evaluate the potential of phage therapy control XDR-PA clinical strains. Bϕ-R1836 belong Siphoviridae family exhibited broad host ranges which could lyse 18 (64%) 14 (50%) 28 In addition, phages showed strong bacteriolytic activity against strains from...
ABSTRACT The increasing prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in intensive care units has caused major problems public health worldwide. Our aim was to determine whether this phage could be used as an alternative therapeutic agent against multidrug-resistant bacterial strains, specifically CRAB clinical isolates, using a mouse model. Ten bacteriophages that lysis including bla OXA-66-like genes, were isolated. YMC13/01/C62 ABA BP (phage Bϕ-C62), which...
The emergence of carbapenem-resistant Acinetobacter baumannii, responsible for causing nosocomial infections, has been becoming a significant global health issue. In this article, we report the complete genome sequence bacteriophage B-B1251 (YMC/09/02/B1251 ABA BP), which causes lysis A. baumannii strain. belongs to family Podoviridae and double-stranded circular DNA with length 45,364 bp 39.05% G+C content. Genome analysis showed that it had no similarity other previously reported...
The aim of this study was to characterize phenotypical properties, analyse whole genomes novel Acinetobacter baumannii phages infecting carbapenem-resistant Ac. (CRAB) and evaluate their potential as antimicrobial alternatives control in clinical settings.The phages, Βϕ-R1215 Βϕ-R2315, were isolated from sewage samples. These characterized by transmission electron microscopy, host spectrum, the thermal/pH stability test, bacterial lysis assay genome analysis. Both lysed 21 45 CRAB hosts,...
Carbapenemase-producing organisms (CPO) are rapidly disseminating worldwide, and their presence in tertiary care hospitals poses a significant threat to the management of nosocomial infections. There is need control CPO, especially intensive unit (ICU) patients, because these resistant most β-lactam antibiotics easily transmitted. At present, identification CPO time-consuming; hence, this study focused on use Xpert CARBA-R assay (Cepheid, USA) determine intestinal colonization rates patients...
Multidrug-resistant Pseudomonas aeruginosa commonly causes serious nosocomial infections. In this study, a novel lytic bacteriophage belonging to member of the family Podoviridae, YMC01/01/P52 PAE BP, which infects carbapenem-resistant aeruginosa, was isolated and characterized. BP genome analyzed by whole-genome sequencing putative function identification. The consists double-stranded linear DNA 49,381 bp with GC content 62.16%.
Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of serious infection, both in the community and hospital settings. Despite sophisticated strategies efforts, antibiotic options for treating MRSA infection have been narrowed due to limited number newly developed antimicrobials. Herein, we analyze completely sequenced genome a novel virulent phage YMC/09/04/R1988 BP as potential alternative anti-MRSA agent, which lysed clinical isolates from patient admitted hip...
본 연구에서는 소재의 IR 분석 및 변형량 측정을 통해 전조등 내측의 결로고장 발생원인을 추정하고자 하였다. 수거한 시장고품을 OM, SEM, CT에 의한 표면 검사를 전면커버와 후면 구조물 사이에 도포된 밀봉용 핫멜트 내에 외부에서 내부로 물이 침투할 수 있는 공극이 존재함을 확인하였다. 침투경로부를 중심으로 분석을 점착제 열화시 발생되는 기능기가 증가되어 있음을 확인하였으며 ESPI 기구적으로 적절히 구속되지 못한 경우, 체결부를 과대한 변형량이 발생함도 또한, 시편을 이용한 고장재현시험으로 체결력이 약한 부분에서 반복적 수축팽창과 특성열화로 발생될 있음도 알 있었다.