A5026169586- Muscle Physiology and Disorders
- Amino Acid Enzymes and Metabolism
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
Institut Pasteur
2023
Centre National de la Recherche Scientifique
2023
Université Paris Cité
2023
Sorbonne Université
2023
The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process unknown. Here we show that the primary cilium acts as a sensor through GPR161. Using an ex vivo neuronal model and microfluidic assays, demonstrate fluid shear stress induces via mechanoreceptor GPR161 at cilium, with its mechanosensitive Helix 8 being essential. We activates recently discovered cAMP/PKA signaling pathway leading to phosphorylation NDE1, dynein complex...
Dysregulation of stem cell properties is a hallmark many pathologies, but the dynamic behaviour cells in their microenvironment during disease progression remains poorly understood. Using mdx mouse model Duchenne Muscular Dystrophy, we developed innovative live-imaging muscle (MuSCs) vivo, and ex vivo on isolated myofibres. We show that MuSCs have impaired migration precocious differentiation through unbalanced symmetric divisions, driven by p38 PI3K signalling pathways, contrast to p38-only...