A5103078122- Pleural and Pulmonary Diseases
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- Dialysis and Renal Disease Management
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Biomedical and Chemical Research
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Cancer survivorship and care
- Philippine History and Culture
- Medical Practices and Rehabilitation
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Ultrasound in Clinical Applications
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Electrolyte and hormonal disorders
- Epigenetics and DNA Methylation
Medizinische Hochschule Brandenburg Theodor Fontane
2017-2024
Klinikum Konstanz
2010-2023
Federal Institute for Population Research
2020
Beiersdorf (Germany)
2019
Universität Greifswald
2004-2013
Universitätsmedizin Greifswald
2005-2012
Medizin Campus Bodensee
2011
University of Bonn
2009
Klinikum Ernst von Bergmann
2008
University Hospital Leipzig
2008
Uraemic pruritus (UP) is still one of the most vexing and disabling symptoms in chronic renal failure. The pathogenesis UP obscure effective therapeutic strategies are elusive. Deduced from partial successful treatment modalities, there evidence that an alteration immune system with a pro-inflammatory pattern along deranged T-helper-cell differentiation may be involved UP. We, therefore, investigated whether related to augmented Th1-differentiation as measured by determination...
The present project involved a collective effort agreed by the European Society of Thoracic Surgeons, American Association for Surgery, and General Surgery Club to assemble joint panel experts review available data address ambiguous aspects chest tube definitions nomenclature. task force was composed 11 invited participants, identified their expertise in area management. subject divided different topics, which were turn assigned at least two experts. draft reports written on each topic...
A paucity of coxsackie adenovirus receptor (CAR) hampers the serotype 5 (Ad5)-based vector-mediated gene transfer into malignant hematopoietic cells. Fiber-retargeted adenoviral vectors with species B tropism can potentially bypass CAR requirement and facilitate efficient cells.For feasible generation fiber-retargeted vectors, we have modified versatile AdEasy system a chimeric fiber encoding Ad5 tail domain Ad35 shaft knob domains. An Ad5-based vector green fluorescent protein (GFP) under...
Abstract The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). significance low level circulating t(14;18)‐positive cells healthy individuals clonal precursors or indicators risk still unclear. We determined the age dependent prevalence and frequency BCL2/IgH rearrangements 715 ranging from newborns to octo‐ nonagenarians. These results were compared with number 108 FL patients at initial presentation. overall...
The study was undertaken to compare antitumor efficacy of electrochemotherapy (ECT) with cold plasma therapy (CP) in a melanoma mouse model. After implantation into the flank C57BL/6N mice, CP by two different sources (APPJ and DBD) applied directly tumor surface. ECT performed bleomycin intravenously at field strength 1000 V/cm without or combined CP. Primary endpoints were growth acceleration (TGA), daily volume progression (DVP) survival after treatment. Both as single treatment showed...
Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection lack efficient treatments. Identifying novel drug targets for this indication may open way new treatment strategies. Comparison gene expression profiles NSCLC normal adjacent tissue (NAT) allowed determine that 5-alpha-reductase type I (SRD5A1) was up-regulated in compared NAT. This raised question whether SRD5A1 involved sustained proliferation survival...
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic management it utmost importance realize parametrize bed verify actual, plan further treatment noninvasive diagnostics. U p now monitoring based on visual inspection wounds as conventionally practiced over more than decades. The main problems are the lack standardization comparability because interindividual variations. Therefore technical performance with...
Abstract Diamond-Blackfan anemia (DBA) is a congenital red-cell aplasia in which 25% of the patients have mutation ribosomal protein (RP) S19 gene. It not known how RPS19 deficiency impairs erythropoiesis and proliferation hematopoietic progenitors. To elucidate molecular mechanisms RPS19-deficient DBA, we analyzed effects on erythropoietin (EPO)-induced signal transduction, cell cycle, apoptosis TF-1 cells. We did find any abnormality EPO-induced transduction. However, cells showed G0/G1...
Several types of peripheral blood cells express ABC transporters. ABCC4 (MRP4) and ABCC5 (MRP5) localize to different cellular sites fulfill lineage-specific functions such as mediator storage in platelets' dense granules. All mature originate from the same precursor specific functionalities arise during differentiation. To characterize this process, expression, localization function MRP4 MRP5 were assessed differentiating human CD34+ progenitors leukemia cell lines using real time...
Diamond–Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have mutation ribosomal protein S19 (RPS19) gene. No models exist for RPS19-deficient DBA and molecular pathogenesis unknown. To establish an vitro inducible model DBA, human erythroid leukemic lines, TF-1 UT-7 cells, were cotransduced with lentiviral vector expressing green fluorescent (GFP) gene small interfering RNA (siRNA) against RPS19 controlled by tet operator regulatory element another...
Summary This study of first‐line treatment in advanced‐stage follicular lymphoma patients analysed the effects MCP (mitoxantrone, chlorambucil and prednisolone) chemotherapy alone or combination with rituximab (R‐MCP) on circulating cells (CLC) assessed prognostic value a quantitative monitoring CLC. CLC numbers were determined by polymerase chain reaction (PCR) for t(14;18)‐translocation allele‐specific PCR rearranged immunoglobulin heavy genes. We blood samples from 43 treated randomized...
Patients with end-stage renal disease (ESRD) are at high risk of hepatitis B infection. Only 50-60% the patients respond adequately to routinely performed intramuscular (i.m.) vaccination. We examined whether low dose intradermal (i.d.) application vaccine is equivalent regular i.m. administration. Thirty-two ESRD different etiologies were investigated onset dialysis treatment [11 on continuous ambulatory peritoneal (CAPD) and 21 hemodialysis (HD)]. vaccinated month 0, 1, 3 6 either 40 μg...
Diamond–Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by specific deficiency in erythroid progenitors. Since some patients with DBA develop reduction thrombocytes and granulocytes age, we asked whether multipotent hematopoietic progenitors from had normal proliferative capacity liquid expansion cultures. CD34+ cells derived showed deficient proliferation culture containing IL-3, IL-6, SCF. Single CD38− exhibited recruitment limiting dilution assay SCF, Tpo,...
Uraemic pruritus is a frequent and disabling symptom in patients on dialysis. The pathogenesis of uraemic nevertheless still obscure. We investigated whether di(2-ethylhexyl)phthalate (DEHP), the most commonly used plasticizer polyvinylchloride (PVC) haemodialysis tubings, possible pathogenetic factor pruritus. Serum concentrations DEHP its major derivatives mono-(2-ethylhexyl)phthalate (MEHP), 2-ethylhexanol (2-EH) phthalic acid (PA) were determined before after session compared with...