A5049797501- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Botulinum Toxin and Related Neurological Disorders
- Children's Physical and Motor Development
- Restless Legs Syndrome Research
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Salmonella and Campylobacter epidemiology
- Muscle activation and electromyography studies
- Parkinson's Disease and Spinal Disorders
- Obsessive-Compulsive Spectrum Disorders
- Nerve injury and regeneration
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Vagus Nerve Stimulation Research
- Viral gastroenteritis research and epidemiology
Maastricht University
2015-2025
Maastricht University Medical Centre
2016-2025
John Wiley & Sons (United States)
2023
European Graduate School of Neuroscience
2020
Neurology, Inc
2006-2016
University Medical Center
2016
Erasmus MC
2007-2013
Erasmus University Rotterdam
2007-2011
Spaarne Ziekenhuis
2009
Rotterdam University of Applied Sciences
2002
Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression Parkinson's disease has stagnated. Consequently, patients do not receive best care, leading to unnecessary disability, mounting costs for society. The Personalized Parkinson Project (PPP) proposes an unbiased approach biomarker development with multiple biomarkers measured longitudinally. main aims are: (a) perform a set hypothesis-driven analyses on comprehensive dataset, correlating established novel...
Abstract Parkinson’s disease symptoms are most often charted using the MDS-UPDRS. Limitations of this approach include subjective character assessments and a discrepant performance in clinic compared to home situation. Continuous monitoring wearable devices is believed eventually replace golden standard, but measurements lack parallel ground truth or only tested lab settings. To overcome these limitations, study explores feasibility newly developed system, which aims measure during daily...
Molecular mimicry between lipooligosaccharides (LOS) of Campylobacter jejuni and gangliosides in peripheral nerves plays a crucial role the pathogenesis C. jejuni-related Guillain-Barré syndrome (GBS). We have analyzed LOS outer core structures 26 strains associated with GBS its variant, Miller Fisher (MFS), by capillary electrophoresis coupled electrospray ionization mass spectrometry. Sixteen out 22 (73%) GBS-associated all 4 (100%) MFS-associated expressed ganglioside mimics. GM1a was...
ABSTRACT Carbohydrate mimicry between Campylobacter jejuni lipooligosaccharides (LOS) and host neural gangliosides plays a crucial role in the pathogenesis of Guillain-Barré syndrome (GBS). LOS may mimic various gangliosides, which affects immunogenicity type neurological deficits GBS patients. Previous studies have shown interaction with sialic acid-specific siglec receptors, although functional consequences remain unknown. Cells that express high levels siglecs include dendritic cells...
ABSTRACT Background Anxiety disorders are among the most prevalent and disabling neuropsychiatric syndromes in patients with Parkinsonʼs disease (PD), but no randomized controlled treatment trials of anxiety have been published to date. Objective The aim this study was assess effectiveness cognitive behavioral therapy (CBT) PD. Methods Forty‐eight PD were 1:1 between CBT clinical monitoring only (CMO). program developed specifically address symptoms consisted 10 weekly sessions. Assessments...
Detection of serum antibodies to myelin-associated glycoprotein (MAG) by Western blot (WB) is a valuable assay diagnose distinct type demyelinating polyneuropathy with immunoglobulin M (IgM) monoclonal gammopathy. In this study, the diagnostic accuracy new and more practical ELISA detect these was validated.Routine WBs from 2 independent laboratories were used anti-MAG IgM in 207 patients neuropathy controls. The sensitivity specificity assays compared related patient clinical...
Abstract In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. LOS modulate dendritic cell (DC) activation and subsequent B proliferation as a possible mechanism for aberrant humoral immune response GBS. Highly purified sialylated isolates from three GBS patients induced human DC maturation secretion inflammatory...
Deep brain stimulation is a treatment for Parkinson's disease and other related disorders, involving the surgical placement of electrodes in deeply situated basal ganglia or thalamic structures. Good clinical outcome requires accurate targeting. However, due to limited visibility target structures on routine MR images, direct targeting can be challenging. Non-clinical scanners with ultra-high magnetic field (7T higher) have potential improve quality these images. This technology report...
Background Parkinson's disease (PD)-related anxiety occurs frequently and may be associated with imbalance between anxiety-related circuits. While the thalamus is a shared region of these circuits, its role in PD-related has not been explored so far. Objective To identify changes volume subnuclei patients anxiety. Methods Cognitively intact PD (n = 105) were divided into two groups based on their score Parkinson scale (PAS): 31 had (Anx-PD) 74 did have (non-Anx-PD). Forty-five healthy...
Abstract Background 22q11.2 deletion syndrome (22q11.2DS) has been associated with increased risk of early‐onset Parkinson's disease (PD). Objective To determine the prevalence and predictors PD in a large international 22q11.2DS sample. Methods The sample comprised 856 adults (median age 28 (range 16–76) years; 53.0% female). was defined as clinical diagnosis by neurologist (including bradykinesia, rest tremor and/or rigidity). Age‐specific were analyzed using Kaplan–Meier curve Cox...
Introduction: The subthalamic nucleus, substantia nigra, and globus pallidus, three nuclei of the human basal ganglia, play an important role in motor, associative, limbic processing. network ganglia is generally characterized by a direct, indirect, hyperdirect pathway. This study aims to investigate mesoscopic nature these connections between pallidus their surrounding structures. Methods: A post mortem brain specimen including was scanned on 7 T MRI scanner. High resolution diffusion...
The continuous monitoring of Parkinsons's disease (PD) symptoms would allow to automatically adjust medication or deep brain stimulation parameters a patient's momentary condition. Wearable sensors have been proposed monitor PD and validated in number lab hospital settings. However, taking these into the daily life patients introduces difficulties, most notably absence an observable ground truth what user is currently doing. In this pilot study, we investigate by combining wearable on both...
Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson’s disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed randomized controlled trial including PD mild impairment. Participants were randomly allocated 12-week home-based CT intervention or waiting-list control group. Assessments at baseline and weeks 12 24. Forty-one...
Introduction Despite careful patient selection for subthalamic nucleus deep brain stimulation (STN DBS), some Parkinson’s disease patients show limited improvement of motor disability. Innovative predictive analysing methods hold potential to develop a tool clinicians that reliably predicts individual postoperative response, by only regarding clinical preoperative variables. The main aim prediction would be improve counselling, expectation management, and satisfaction. Methods We developed...
Motor fluctuations in Parkinson's disease are characterized by unpredictability the timing and duration of dopaminergic therapeutic benefits on symptoms, including bradykinesia rigidity. These significantly impair quality life many patients. However, current clinical evaluation tools not designed for continuous, naturalistic (real-world) symptom monitoring needed to optimize therapy treat fluctuations. Although commercially available wearable motor monitoring, used over multiple days, can...
Objective: The aim of this work was to investigate marker profiles for proposed anxiety subtypes in Parkinson disease (PD). Methods: We used the persistent anxiety, episodic and avoidance behavior subscales Anxiety Scale as dependent variables multivariable linear regression analyses using a cross-sectional data set 311 patients with PD. Independent consisted range demographic, psychiatric, disease-specific markers. Results: In most parsimonious model higher Hamilton Depression Rating...