A5081846473- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Autoimmune and Inflammatory Disorders
- Cervical Cancer and HPV Research
- Parvovirus B19 Infection Studies
- Genital Health and Disease
- Immunotherapy and Immune Responses
- Adolescent Sexual and Reproductive Health
- Vasculitis and related conditions
- Eosinophilic Esophagitis
- Dermatological and COVID-19 studies
- Reproductive Health and Contraception
- Women's cancer prevention and management
- Cancer Risks and Factors
- Reproductive tract infections research
- Renal Diseases and Glomerulopathies
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Disorders and Syndromes
- Breastfeeding Practices and Influences
Universidade do Estado do Rio de Janeiro
2017-2025
Hospital Universitário Pedro Ernesto
2018-2023
Fundação Oswaldo Cruz
2023
Hospital Federal dos Servidores do Estado
2020
Objective This study analyzed longitudinal trajectories of soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) sFlt‐1/PlGF ratio in a cohort pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14‐18, 24‐26, 30‐32, 34‐36 38‐40 weeks), stored at ‐80°C evaluated for serum levels sFlt‐1, PlGF sFlt1/PlGF ratios. Patients classified as inactive SLE (SLEPDAI < 4), active disease > or preeclampsia (PE). Medians...
To analyze the impact of different classes lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort pregnant patients.This is study with retrospective prospective data collection, conducted at University Hospital State Rio de Janeiro, Brazil, from 2011 to 2016. A total 147 pregnancies 137 systemic erythematosus patients whom 66 had were included. Demographic clinical features, well observed each histological class among compared those without nephritis....
Objective To evaluate mean serum levels of vascular endothelial growth factor (VEGF), placental (PlGF), and soluble Flt‐1 (sFlt‐1) in pregnant patients with systemic lupus erythematosus (SLE) inactive disease, active nephritis, preeclampsia for differential diagnosis between these conditions. Methods Pregnant women SLE, singleton pregnancies no other autoimmune diseases, were classified according to disease activity (inactive SLE nephritis) the presence preeclampsia. Serum samples collected...
Acute vulvar ulcer (Lipschütz's ulcer) is a rare lesion with local hyperimmunoreactivity triggered by infection, which characterized acute, painful, and necrotic ulcerations. This condition usually found in non-sexually active adolescents, it resolves spontaneously. We report case of 35-year-old woman who was diagnosed COVID-19 did not have severe symptoms, but had high levels D-dimer for 9 days. The diagnosis followed the appearance an necrotic, extremely painful ulcer, although symptoms...
This study analyzed maternal and fetal outcomes of pregnancies neuropsychiatric systemic lupus erythematosus patients followed in a reference unit. retrospective cohort included 26 seen between 2011 2015 with history and/or active among 135 pregnancies. Three had at conception, but only one remained neurological activity during gestation, characteristically related to the inadvertent suspension medications. Twenty six percent newborns were small for gestational age 40% live births premature,...
This article describes three complicated cases in rheumatology and pregnancy. The first case elucidates the challenges treating SLE conjunction with pulmonary arterial hypertension, while second features an SLE-affected pregnancy development of portal hypertension secondary to vein thrombosis related APS. third is a pregnant woman stable who developed thrombotic microangiopathy caused by atypical haemolytic uraemic syndrome, failed improve despite multiple measures including biopsy elective...
SUMMARY OBJECTIVE: The aim of this study was to analyze the occurrence and risk factors associated with infections during pregnancy in patients systemic lupus erythematosus. METHODS: This is a retrospective cohort using data pregnant women who were followed up between 2011 2018 at university hospital. RESULTS: 221 erythematosus analyzed. incidence 22.6% (50/221), urinary tract being most frequent site infection (32/221, 14.5%) by respiratory (15/221, 6.8%). bivariate analysis showed that...
The objective of this study was to evaluate the potential impact irreversible damage accrual in women with systemic lupus erythematosus (SLE) and adverse maternal and/or fetal/neonatal outcomes.Retrospective cohort SLE pregnant patients carried out from January 2011 2020 at Hospital University Pedro Ernesto (HUPE) State Rio de Janeiro, Brazil. Irreversible defined according SLICC/ACR index (SDI). association SDI on pregnancy outcomes established by univariate multivariate regression models...
The present paper aims to outline the panorama of cervical cancer in Brazil, correlating particularities these data and their costs scenario Brazilian Army, by conducting a retrospective cross-sectional study military population attended Praia Vermelha Military Polyclinic Rio de Janeiro, period December 2011 July 2014.The authors use an auxiliary tool for obtaining database, finite sampling quotas age with 95% confidence interval error 5%.Such is relevant when consider statistical that...
Abstract Patients with systemic lupus erythematosus have a higher incidence of neoplasms associated human papillomavirus infections, such as those that affect the vulva, vagina, and cervix; however, little is known about frequency anal cancer among these patients. Although there are recommendations for screening this in immunosuppressed individuals, it possible procedure not strictly followed. We describe case 47-year-old woman who was treated immunosuppressants developed advanced squamous...
Introdução: A amamentação é uma prática de suma importância para a saúde materna e neonatal. O aleitamento materno exclusivo recomendado por, pelo menos, 4 meses está associado, acordo com Organização Mundial Saúde (OMS), redução 13% na mortalidade infantil até os 5 anos. Apesar dos benefícios, muitas pacientes portadoras doenças crônicas, como o caso do lúpus eritematoso sistêmico (LES), são desencorajadas mal orientadas sobre realização materno. Objetivo: Descrever forma tempo LES...
Introdução: O lúpus eritematoso sistêmico (LES) é uma doença que afeta principalmente mulheres em idade reprodutiva, e a nefrite lúpica (NL) manifestação frequente, com um aumento do risco de complicações. micofenolato mofetil (MMF) medicamento imunossupressor atualmente considerado o tratamento primeira linha para NL. No entanto, desde relato primeiro caso malformação congênita associada ao uso materno MMF na década 1990, esses imunossupressores têm sido evitados pacientes planejam...
Introdução: O lúpus eritematoso sistêmico (LES) tem maior incidência e prevalência em mulheres no período do menacme certas medicações para o tratamento desta comorbidade, como a ciclofosfamida (CTX), micofenolato mofetil (MMF) metotrexato (MTX), têm potencial teratogênico. Alterações cardíacas, esofágicas, auditivas, renais de membros são relatadas especialmente com MMF, enquanto MTX, por ser antagonista ácido fólico, pode ter associação mielomeningocele disfunções sistema nervoso central....
Úlcera de Lipschütz (LU) em adolescente, como manifestação da primoinfecção por Epstein-Barr (EBV). Relato
Introdução: As mulheres grávidas têm um risco quatro vezes maior para tromboembolismo em comparação a não grávidas. Entre as pacientes que apresentam trombose arterial e/ou venosa recorrente, recomenda-se pesquisa de anticorpos antifosfolípides (aPL), como anticorpo anticardiolipina, anticoagulante lúpico, antibeta2 glicoproteína I, o diagnóstico da Síndrome Antifosfolipídeo (SAF). Objetivo: Comparar os resultados gestacionais apresentaram profunda (TVP) sem aPL com SAF história vascular....
Introdução: As infecções sexualmente transmissíveis (IST) incluem um grupo de doenças interesse tanto na saúde pública quanto privada, dada sua alta prevalência. O termo IST substituiu o anterior pela característica assintomática algumas. Entre elas, a clamídia e gonorreia, maioria dos casos, não provocam sintomas, mas podem ter repercussões consideráveis em ambos os sexos, especialmente fertilidade, uma forma rastreio deve ser discutida. Objetivos: Propor rotina para gonorreia clínicas...