A5044423712- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Coal Properties and Utilization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hepatocellular Carcinoma Treatment and Prognosis
- Optical Imaging and Spectroscopy Techniques
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Vasculitis and related conditions
- Ferroptosis and cancer prognosis
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Body Composition Measurement Techniques
- Ultrasound in Clinical Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
- COVID-19 and Mental Health
Xiangya Hospital Central South University
2021-2024
Central South University
2013-2024
Intensive Care Society
2023
Third Xiangya Hospital
2015
Abstract Background Sepsis-related acute kidney injury (AKI) is an inflammatory disease associated with extremely high mortality and health burden. This study explored the possibility of exosomes secreted by adipose-derived mesenchymal stem cells (AMSCs) serving as a carrier for microRNA (miR)-342-5p to alleviate sepsis-related AKI investigated possible mechanism. Methods Serum was obtained from 30 patients sepsis-associated healthy volunteers measurement miR-342-5p, blood urea nitrogen...
N6-methyladenosine (m6A) and MELLT3 assume a role in the development of acute kidney injury (AKI). However, their mechanism AKI remains under-explored. On this basis, study explored mitochondrial damage ferroptosis tubular epithelial cells after AKI. HK-2 were induced by lipopolysaccharide (LPS) to simulate AKI, followed gain loss function genes, detection indicators, analysis gene interactions. An mouse model was developed using cecal ligation puncture (CLP) method investigate effect METTL3...
Background: Since the coronavirus disease-2019 (COVID-19) outbreak, intensive care unit (ICU) healthcare workers were responsible for critical infected patients. However, few studies focused on mental health of ICU workers. This study aimed to investigate psychological impact COVID-19 in China. Methods: We distributed nine-item Patient Health Questionnaire (PHQ-9) and seven-item General Anxiety Disorder questionnaire (GAD-7) online Respondents divided into frontline second-line according...
MicroRNAs (miRNAs) are involved in the pathogenesis of intrahepatic cholangiocarcinoma (ICC). However, role microRNA-31 (miR-31) ICC has yet to be elucidated. In this study, we demonstrated that expression miR-31 was significantly upregulated tissues and human cell line HCCC-9810, when compared with normal adjacent tissues. Bioinformatic analysis a dual-luciferase reporter assay revealed RAS p21 GTPase activating protein 1 (RASA1) direct target HCCC-9810 cells. Further investigation showed...
Background Acute kidney disease (AKD) affects more than half of critically ill elderly patients with acute injury (AKI), which leads to worse short-term outcomes. Objective We aimed establish 2 machine learning models predict the risk and prognosis AKD in deploy as online apps. Methods Data on AKI (n=3542) (n=2661) from Medical Information Mart for Intensive Care IV (MIMIC-IV) database were used develop predicting in-hospital mortality, respectively. collected Xiangya Hospital Central South...
When resuscitating patients with septic shock, cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation (rSO
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer with poor responsiveness to existing drug therapies. Therefore, novel treatment strategies against ICC are required improve survival. The aim of this study was demonstrate role fused-in-glioblastoma-c-ros-oncogene1 (FIG-ROS) fusion gene in ICC. ROS positively expressed tissues and HUCCT1 cells. Plasmids expressing ROS- FIG-specific shRNAs were constructed transfected into results showed that single...
Background Acute kidney injury (AKI) is more likely to develop in the elderly admitted intensive care unit (ICU). disease (AKD) affects ∼45% of patients with AKI and increases short-term mortality. However, there are no studies on prognosis AKD elderly.Methods Data from 2666 Medical Information Mart for Intensive Care IV were used model development 535 eICU Collaborative Research Database external validation. Based 5 machine learning algorithms, 33 noninvasive parameters extracted as...
Approximately one-third of patients with sepsis-associated acute kidney injury (AKI) progress to disease (AKD) higher short-term mortality. We aimed identify the clinical characteristics that influence in-hospital death in AKD and develop a nomogram facilitate early warning.Logical regression was applied screen variables based on data from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. A established predict risk AKD. The eICU Collaborative Research Database (eICU-CRD)...
Using optics combined with automatic control and computer real-time image detection technology, a novel noninvasive method of noncontact pressure manometry was developed based on the airflow laser technology in this study. The new esoph
Both anti-glomerular basement membrane (GBM) disease and the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are common causes of pulmonary-renal syndrome. Organizing pneumonia (OP), a special pattern interstitial lung disease, is extremely rare either in AAV or anti-GBM disease. We report an old woman presented with OP on background co-presentation both ANCA antibodies.
<sec> <title>BACKGROUND</title> Acute kidney disease (AKD) affects more than half of critically ill elderly patients with acute injury (AKI), which leads to worse short-term outcomes. </sec> <title>OBJECTIVE</title> We aimed establish 2 machine learning models predict the risk and prognosis AKD in deploy as online apps. <title>METHODS</title> Data on AKI (n=3542) (n=2661) from Medical Information Mart for Intensive Care IV (MIMIC-IV) database were used develop predicting in-hospital...
Objective To investigate the characteristics of lung ultrasound images in critical care postoperative patients using BLUE-plus protocol. Methods Two hundred and twenty-two who were performed measurements according to protocol within 24 hours admitted Department included this study. Data was collected retrospectively analyzed compare proportion different signs at speculate regions, undergo surgeries. Results Excluding A lines, most common abnormal diaphragmatic points B7 lines...
Objective To investigate the clearance rate of calcium in ultrafiltrate and to determine whether it can be used as a reference indicator for supplementation patients during continuous venous-venous hemofiltration (CVVH) treatment with local sodium citrate anticoagulation. Methods Fifty-five at high risk bleeding who required renal replacement therapy (CRRT) were included. They underwent CVVH anticoagulant citrate, 4% was 200 ml/h. In first stage experiment, totally post-dilutional...
Abstract Aim: To investigate the efficacy of Tigecycline (TG) or polymyxin B(PB) against Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection in ICUs. Method: Electronic medical record systems were used to capture CRKP-infected patients who treated with TG- PB-based therapies from ICUs four academic hospitals Hunan, China. Propensity-score matching and logistic regression compare find prognostic factors. Results: Of 236 patients, 106 received TG-based therapy (TG), 102 (PB), 28 a...