A5074766156- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- Magnesium Alloys: Properties and Applications
- Anodic Oxide Films and Nanostructures
- Titanium Alloys Microstructure and Properties
- Additive Manufacturing and 3D Printing Technologies
- Corrosion Behavior and Inhibition
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Advanced Materials and Mechanics
- Nanofabrication and Lithography Techniques
- Aluminum Alloys Composites Properties
- Laser-Ablation Synthesis of Nanoparticles
- Semiconductor materials and devices
- Orthopedic Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Osteoarthritis Treatment and Mechanisms
- Concrete Corrosion and Durability
- Advanced Drug Delivery Systems
- Modular Robots and Swarm Intelligence
- Dental materials and restorations
- Cellular and Composite Structures
- Cancer Cells and Metastasis
Delft University of Technology
2016-2025
Faculty (United Kingdom)
2020
California Maritime Academy
2019
National Institute of Research and Development for Technical Physics
2002
IHE Delft Institute for Water Education
1999
Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, tissue formation. However, it remains largely unclear how collectively explore pattern complex landscapes with curvature gradients across the Euclidean non-Euclidean spectra. Here, we show that mathematically designed substrates controlled variations induce spatiotemporal organization of preosteoblasts. We quantify curvature-induced patterning find generally...
Abstract The existing 3D printing methods exhibit certain fabrication-dependent limitations for curved constructs that are relevant many tissues. Four-dimensional (4D) is an emerging technology expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D based on printing, featuring introduction time as fourth dimension, in which there a transition from printed scaffold new, distinct, stable state, upon application one or more stimuli. Here, we present...
Zinc and zirconium were selected as the alloying elements in biodegradable magnesium alloys, considering their strengthening effect good biocompatibility. The degradation rate, hydrogen evolution, ion release, surface layer vitro cytotoxicity of two Mg–Zn–Zr i.e. ZK30 ZK60, a WE-type alloy (Mg–Y–RE–Zr) investigated by means long-term static immersion testing Hank’s solution, non-static solution cell-material interaction analysis. It was found that, among these three had lowest rate least...
Exploiting the synergistic antibacterial behavior of Ag and Cu nanoparticles in self-defending implants.
Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) are otherwise very challenging to process using other additive manufacturing techniques. Iron one have been recently shown be amenable processing this approach. Indeed, fully interconnected design has potential resolving fundamental issue regarding bulk iron, namely low rate biodegradation. However, no extensive...
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining with time-dependent stimuli-induced transformation, enables shape-changing Here, a biofabrication method reported for cartilage engineering based differential swelling smart multi-material system made from two hydrogel-based materials: hyaluronan and alginate. Two ink formulations are used: tyramine-functionalized (HAT,...
Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate biodegradation and insufficient bioactivity. While additively manufactured porous iron has somewhat successful in addressing first challenge, limited bioactivity these biomaterials hinder their progress towards clinical application. Herein, we extrusion-based 3D printing for iron-matrix composites containing...
Abstract Durable interfacing of hard and soft materials is a major design challenge caused by the ensuing stress concentrations. In nature, soft-hard interfaces exhibit remarkable mechanical performance, with failures rarely happening at interface. Here, we mimic strategies observed in nature to efficient interfaces. We base our geometrical designs on triply periodic minimal surfaces (i.e., Octo, Diamond, Gyroid), collagen-like triple helices, randomly distributed particles. A combination...
The Poisson's ratio and elastic modulus are two parameters determining the behavior of biomaterials. While effects on cell response is widely studied, very little known regarding ratio. micro-architecture meta-biomaterials determines not only but also several other that influence response, such as porosity, pore size, effective modulus. It is, therefore, challenging to isolate from those micro-architectural parameters. Here, we computationally design with controlled ratios, ranging between...
We introduce folding strategies to fabricate lattice structures with arbitrarily complex surface (nano-) ornaments.
Abstract Development of synthetic bactericidal surfaces is a drug‐free route to the prevention implant‐associated infections. Surface nanotopographies with specific dimensions have been shown kill various types bacterial strains through mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective ranges required simultaneously achieve both aims are in <200 nm range. Here, nanoscale additive manufacturing (=3D printing) technique called electron...
The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application limited by fast degradation. Adding bioceramic particles into to form Mg-matrix composites promising strategy adjust biodegradation rates and improve mechanical properties cytocompatibility further. Here, we developed an extrusion-based additive manufacturing technique fabricate biodegradable...
The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most the challenges encountered developing such have been tackled individually or combination using additive manufacturing technologies. Yet not all overcome. Herein, we present porous FeMn-akermanite composite scaffolds fabricated by extrusion-based 3D printing to address unmet clinical needs associated with biomaterials for regeneration, including low biodegradation rate, MRI-incompatibility,...