A5053804505- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Neonatal and fetal brain pathology
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Prenatal Substance Exposure Effects
- Congenital heart defects research
- RNA and protein synthesis mechanisms
- Amphibian and Reptile Biology
- Bipolar Disorder and Treatment
- Genomic variations and chromosomal abnormalities
University of Zagreb
2013-2024
Rudjer Boskovic Institute
2000-2010
University of Pennsylvania
2002
Institute of Neurobiology
1998
OBJECTIVE: An association between the 5-HTTLPR short variant polymorphism in promoter region of serotonin transporter gene and risk for alcohol dependence has been reported from case-control studies that are, however, prone to chance findings related artifacts population structure. The authors sought additional evidence this a family-based study. METHOD: Ninety-two alcohol-dependent probands their parents were tested nonrandom transmission alleles heterozygous affected probands. RESULTS:...
We tested the hypothesis that gestational diabetes mellitus (GDM) alters DNA methylation pattern of fetal serotonin transporter gene (SLC6A4), and examined functional relevance for regulation SLC6A4 expression in human placenta. The study included 50 mother-infant pairs. Eighteen mothers were diagnosed with GDM 32 had normal glucose tolerance (NGT). All neonates birth weight born at term by planned Cesarean section. RNA isolated from samples tissue collected side placenta immediately after...
Abstract Background Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other physiological processes. DNA methylation plays a significant role modulating the expression of genes responsible for maintaining 5-HT balance, such as transporter ( SLC6A4 ), monoamine oxidase A MAOA receptor type 2A HTR2A ). Maternal metabolic health can influence long-term outcomes offspring, with mediating these effects. We investigated...
Adversities during the perinatal period can decrease oxygen supply to fetal brain, leading various hypoxic brain injuries, which compromise regularity of development in different aspects. To examine catecholaminergic contribution link between an early-life insult and adolescent behavioral aberrations, we used a previously established rat model hypoxia but altered hypobaric normobaric conditions. Exploratory social behavior learning abilities were tested 70 rats both sexes at age. Inherent...
Disturbed brain and peripheral serotonin homeostasis is often found in subjects with autism spectrum disorder (ASD). The role of the receptor 2A (HTR2A) regulation central homeostasis, as well its altered expression autistic subjects, have implicated HTR2A gene a major candidate for disturbance seen autism. Several studies, yielding so far inconclusive results, attempted to associate functional SNP -1438 G/A (rs6311) promoter region, while possible contribution epigenetic mechanisms, such...
The serotonin receptor 2A gene (HTR2A) is a strong candidate for the fetal programming of future behavior and metabolism. Maternal obesity gestational diabetes mellitus (GDM) have been associated with an increased risk metabolic psychological problems in offspring. We tested hypothesis that maternal status affects methylation HTR2A placenta. prospective study included 199 pairs mothers healthy full-term newborns. Genomic DNA was extracted from feto-placental samples analyzed genotypes two...
This study was designed in a rat model to determine the hallmarks of possible permanent behavioral and structural brain alterations after single moderate hypoxic insult. Eighty-two Wistar Han (RccHan: WIST) rats were randomly subjected hypoxia (pO2 73 mmHg/2 h) or normoxia at first postnatal day. The substantially increased blood lactate, significantly decreased cytochrome-C-oxygenase expression brain, depleted subventricular zone suggested high vulnerability subset cell populations...
Genome-wide studies on autism spectrum disorders (ASDs) have mostly focused large-scale population samples, but examination of rare variations in isolated populations may provide additional insights into the disease pathogenesis. As a first step genetic analysis ASD Croatia, we characterized variation sample 103 subjects with and 203 control individuals, who were genotyped using Illumina HumanHap550 BeadChip. We analyzed diversity Croatian its relationship to other populations, degree...
Serotonin (5-hydroxytryptamine, 5HT) homeostasis is essential for many physiological processes in the central nervous system and peripheral tissues. Hyperserotonemia, a measurable sign of 5HT disruption, can be caused by 5HT-directed treatment psychiatric gastrointestinal diseases. Its impact on long-term balance function compartment remains unresolved requires further research due to possible effects human health. We explored perinatal imbalance organs responsible serotonin metabolism—the...
Objective and Background .—Serotonergic mechanisms play an important role in the pathogenesis of headache. To search for potential indicators altered serotonin homeostasis migraine, we have investigated three parameters platelet (5HT) system, level (PSL), uptake (PSU), monoamine oxidase (MAO‐B) activity, a group 55 patients with migraine 81 healthy controls. Methods .—After separation, PSL was determined fluorimetrically; PSU measured by incubating aliquots platelet‐rich plasma six...