A5101558552- Brucella: diagnosis, epidemiology, treatment
- Streptococcal Infections and Treatments
- Nigella sativa pharmacological applications
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Dermatological and COVID-19 studies
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Diabetic Foot Ulcer Assessment and Management
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Hematological disorders and diagnostics
- Biochemical effects in animals
- Circadian rhythm and melatonin
- Yersinia bacterium, plague, ectoparasites research
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Parasitic Infections and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Chemotherapy-induced organ toxicity mitigation
- Organoselenium and organotellurium chemistry
Ankara Bilkent City Hospital
2024
Bilkent University
2024
Sağlık Bilimleri Üniversitesi
2021
Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi
2021
Süleyman Demirel University
2018
Turkish Armed Forces
2008-2016
Gülhane Askerî Tıp Akademisi
2009-2016
Türkiye Yüksek İhtisas Hastanesi
2015
Keio University
2015
Military Medical Academy
2008-2012
Abstract The aim of the present study was to evaluate possible protective effects Nigella sativa L. (NS) against β‐cell damage from streptozotocin (STZ)‐induced diabetes in rats. STZ injected intraperitoneally at a single dose 50 mg/kg induce diabetes. NS (0.2 ml/kg/day, i.p.) for 3 days prior administration, and these injections were continued throughout 4‐week study. Oxidative stress is believed play role pathogenesis mellitus (DM). To assess changes cellular antioxidant defense system, we...
<h2>Abstract</h2><h3>Objectives</h3> We described the clinical outcomes of diabetic patients who had foot infections with multidrug resistant organisms. <h3>Methods</h3> included (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients severe infection, complicated moderate infection were hospitalized. The followed-up for 6 months after discharge. <h3>Results</h3> In total, 791 included, 531(67%) male, median age 62 (19–90)....
The aim of the present study was evaluation possible protective effects exercise against β-cell damage in streptozotocin (STZ)-induced diabetes rats. animals were divided into five groups: control group, STZ-induced and light-intensity moderate-intensity heavy-intensity group. Animals groups made to swim one three protocols once a day for 12 consecutive weeks. STZ injected intraperitoneally at single dose 50 mg/kg induction. Exercise training continued 4 weeks prior administration; these...
The aim of this study was to investigate the possible beneficial effects Nigella sativa (NS) in comparison methylprednisolone on experimental spinal cord injury (SCI) rats. SCI performed by placing an aneurysm clip extradurally at level T11-12. Rats were neurologically tested over 24 h after trauma and tissue samples harvested for both biochemical histopathological evaluation. neurological scores rats not found be different groups. significantly increased malondialdehyde (MDA) protein...
Abstract Background Chat Generative Pre-Trained Transformer-v4 (ChatGPT-v4) is an unquestionable asset to healthcare professionals. This paper will outline a number of ways in which ChatGPT-v4 can be used improve the accuracy its diagnosis and treatment strategies for ulcerative colitis (UC) Crohn’s disease (CD), line with ECCO guidelines. Methods 102-item questionnaire was designed assess accuracy, consistenacy, inclusiveness responses questions about UC CD. The created form true/false...
Abstract: Cyclophosphamide (CP), an alkylating antineoplastic agent, has potential urotoxicity including causing hemorrhagic cystitis (HC). HC is now accepted as a non‐infectious inflammation and the pathogenesis of includes cytokine production which leads to inducible nitric oxide synthase (iNOS) induction. Moreover, overproduction reactive oxygen species (ROS) during extensive oxidative stress, cellular injury apoptosis/necrosis via several mechanisms. Based on these facts, aim this study...
Various therapeutic protocols were used for the management of sepsis including hyperbaric oxygen (HBO) therapy.It has been shown that ozone therapy (OT) reduced inflammation in several entities and exhibits some similarity with HBO regard to mechanisms action.We designed a study evaluate efficacy OT an experimental rat model c o m p r e w i t h H B O .M l W s d v n , + f p-sis+cefepime+HBO, sepsis+cefepime+OT groups.Sepsis was induced by intraperitoneal injection Escherichia coli;...
Free radicals have been reported to be responsible for many ailments including gastroduodenal ulcers. Recent studies demonstrated that quercetin (QE) has an antioxidant effects on injuries caused by various toxic agents in different experimental models. In our study, we examined anti-ulcerogen and of ethanol-induced gastric lesions rats. QE was administered intraperitoneally (i.p.) 50 mg/kg. It found pretreatment with significantly reduced damage malondialdehyde levels, increased enzyme...
Our aims were to evaluate the efficacy of ozone therapy (OT) in an experimental rat model acute necrotizing pancreatitis (ANP) and compare its effects with hyperbaric oxygen (HBO) this entity.Forty Sprague-Dawley rats divided into sham-operated, ANP, ANP + HBO, OT groups. Acute was induced by infusing 1-mL/kg 3% sodium taurocholate common biliopancreatic duct. Hyperbaric administered twice daily at a 2.8-atm pressure for 90 minutes. Ozone set as intraperitoneal injections 0.7-mg/kg...
Abstract: Studies have shown that ischemia–reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage of the nervous tissue. Melatonin, a main secretory product pineal gland, has radical scavenging antioxidant properties been diminish I/R injury in many tissues. There are limited number studies related effects melatonin on peripheral system. Therefore, present study, protective effect was investigated rats subjected 2 hr sciatic nerve ischemia followed by 3...
It was previously shown that nitric oxide (NO) produced by inducible NO synthase (iNOS) is responsible for cyclophosphamide (CP) induced cystitis. In this study we evaluated whether peroxynitrite also CP bladder damage in rats.A total of 38 male albino Wistar rats were divided into 4 groups. Group 1 served as controls and given 2 ml saline, while 3 groups received a single dose (200 mg/kg) at the same intervals. only, group selective iNOS inhibitor aminoguanidine (AG) (100 scavenger ebselen...
This study was designed to investigate the protective effects of vitamin C and A on oxidative renal tissue damage. Male Wistar rats were given an intraperitoneal injection 0.5 ml saline (control) or solution lipopolysaccharide (10 mg/kg), which caused endotoxemia. Immediately (within 5 min) after endotoxin injection, endotoxemic untreated treated with (195 mg/kg bw), (500 bw) their combination. After 24 hours, blood samples obtained for histopathological biochemical investigation. Endotoxin...