A5101778127- Photonic and Optical Devices
- Tryptophan and brain disorders
- Nonlinear Optical Materials Research
- Pain Mechanisms and Treatments
- Semiconductor Lasers and Optical Devices
- Stress Responses and Cortisol
- Gastrointestinal motility and disorders
- Advanced materials and composites
- Advanced ceramic materials synthesis
- Advanced Fiber Laser Technologies
- Gut microbiota and health
- Advancements in PLL and VCO Technologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Adhesion, Friction, and Surface Interactions
- Liquid Crystal Research Advancements
- Pharmacological Effects of Natural Compounds
- Orthopaedic implants and arthroplasty
- Immune cells in cancer
- Transcranial Magnetic Stimulation Studies
- Health and Well-being Studies
- Mechanical and Optical Resonators
- Nonlinear Optical Materials Studies
- Thin-Film Transistor Technologies
- Advanced Photonic Communication Systems
- Axon Guidance and Neuronal Signaling
Shenzhen University
2023-2025
Shanghai Mental Health Center
2016-2024
Shanghai Jiao Tong University
2016-2024
Beijing University of Technology
2021-2024
Southern University of Science and Technology
2024
University of Houston
2016-2024
Shenzhen Bay Laboratory
2023
Shenzhen University Health Science Center
2020-2021
Guangzhou Experimental Station
2021
University of Arizona
2014-2015
Yttria partially stabilized zirconia was introduced into WC-Co cemented carbides to enhance their mechanical performance. The hardness and fracture toughness were improved simultaneously with the addition of ZrO2. Particularly, significantly enhanced. mechanism mainly attributed stress-induced phase transformation tetragonal ZrO2 monoclinic This a compressive stress field deflected micro-cracks. In addition, particles dispersed homogeneously in WC skeleton had good interfacial bonding both...
Although the link between gut microbiota and depression has been suggested, changes of vary largely among individuals with depression.Explore heterogeneity microbiota-gut-brain axis new pathogenic characteristics in murine models depression.Adolescent female mice were randomly divided into control (CON) group (n=10), chronic unexpected mild stress (CUMS) (n=15) dexamethasone (DEX) (n=15). Mice DEX gavaged twice a day 0.2 mg/kg for 5 weeks, whereas CON given same amount solvent. CUMS exposed...
Abstract Aim This study aimed to investigate the regulation of pain hypersensitivity induced by spinal synaptic transmission mechanisms underlying interleukin (IL)‐10 and glucagon‐like peptide 1 receptor (GLP‐1R) agonist exenatide‐induced anti‐hypersensitivity in neuropathic rats through nerve ligations. Methods Neuropathic model was established ligation L5/L6 verified electrophysiological recording immunofluorescence staining. Microglial expression β‐endorphin autocrine IL‐10‐ inhibition...
Schizophrenia is a serious mental illness affecting approximately 20 million individuals globally. Both genetic and environmental factors contribute to the illness. If left undiagnosed untreated, schizophrenia results in impaired social function, repeated hospital admissions, reduced quality of life decreased expectancy. Clinical diagnosis largely relies on subjective evidence, including self-reported experiences, reported behavioural abnormalities followed by psychiatric evaluation. In...
Ceramic-based composites generally have low fracture toughness, and toughening these materials without sacrificing their hardness has been a big challenge. This study presents an approach for ceramic-based by modulating the strain partition stress distribution in phase-boundary regions. A new concept of homogenizing lattice to achieve high toughness is proposed based on collective shear martensitic phase transformation. The strategy was demonstrated ZrO2-containing WC-Co ceramic-metal as...
Background Advancements in research have confirmed that gut microbiota can influence health through the microbiota–gut–brain axis. Meditation, as an inner mental exercise, positively impact regulation of individual’s physical and health. However, few studies comprehensively investigated faecal following long-term (several years) deep meditation. Therefore, we propose meditation may regulate homeostasis and, turn, affect Aims To investigate effects on microbiome structure. Methods examine...
Increasing evidence indicates an interaction between dysbiosis of the microbiota and pathogenesis schizophrenia. However, limited information is available on specific microbial communities associated with symptoms Therefore, this study aimed to investigate gut its relationship psychopathologies in We recruited 126 participants divided them into three groups according Diagnostic Statistical Manual Mental Disorders, Fifth Edition, criteria—acute group (patients acute schizophrenia), remission...
Abstract Acute myeloid leukemia (AML) is a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance natural killer (NK) by gene mutation, fusions and epigenetic modification. The mechanism immune evasion not clearly understood. Here we show that CD48 high expression favorable prognosis factor down-regulated in patients, which help evade from NK cell recognition killing. Furthermore, demonstrate regulated methylation hypomethylating agent increase the expression,...
Major depressive disorder (MDD) and chronic pain are two complex disorders that often coexist. The underlying basis for this comorbidity is unknown. In the current investigation, microglia brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) pathway were investigated. A model, with characteristics of both MDD pain, was developed by administration dextran sodium sulfate (DSS) induction unpredictable psychological stress (CUS). Mechanical threshold sensory...
Neonatal or infant period is a critical stage for the development of brain neuroplasticity. Early life stresses in neonatal period, including maternal separation (NMS), have adverse effects on increased risk psychiatric disorders juveniles and adults. However, underlying molecular mechanisms are not largely understood. Here, we found that juvenile rats subjected to daily 4 hour NMS during postnatal day (PND) 1-PND 20 exhibited autism-like behavioral deficits without impairments learning...
Neuropathic pain (NP), resulting from nerve injury, alters neural plasticity in spinal cord and brain via the release of inflammatory mediators. The remodeling store-operated calcium entry (SOCE) involves refilling endoplasmic reticulum STIM1 Orai1 proteins is crucial for maintaining neurotransmitter release. mechanism underlying SOCE-mediated NP remains largely unknown. In this study, we found was significantly higher during neuropathic pain, major component specifically co-localized with...
Background. Neuropathic pain is a common chronic pain, which related to hypersensitivity stimulus and greatly affects the quality of life patients. Maladaptive gene changes molecular signaling underlie sensitization nociceptive pathways. We previously found that activation microglial glucagon-like peptide 1 receptor (GLP-1R) could potently relieve formalin-, bone cancer-, peripheral nerve injury-, diabetes-induced hypersensitivity. So far, little known about how profile upon GLP-1R in...
A low half-wave voltage V(pi) of 1.57 V was obtained with a 2-cm-long birefringent polymer waveguide modulator at wavelength 1.3 microm by use design constant-bias electric field and high-microbeta chromophore. The allows the maximum achievable electro-optic coefficient material to be utilized. This can more than twice as high residue value that is used conventional designs, after fast partial relaxation following poling.
Ultrahigh-speed integrated electrooptic polymer phase modulators have been fabricated and tested. They are made from a new nonlinear optical polymer, amino phenylene isophorone isoxazolone (APII), incorporated with high-speed electrode transitions for W-band (75-110 GHz) operation. This has also used to fabricate Mach-Zehnder modulators. These devices show good performance over wide frequency band ranging 40 GHz V/spl pi/<10 V. The measurements establish APII, other chromophores specially...
The input-output and discharge properties of neurons are shaped by both passive active electrophysiological membrane properties. Whole cell patch-clamp recordings in lamina I-III an isolated preparation the whole spinal cord juvenile rats with attached dorsal roots root ganglia were used to further define which these provides most impactful classification strategy. A total 95 recorded segment L5 classified based on responses L4 stimulation. results showed that high-threshold silent had...