A5101787848- Respiratory viral infections research
- Renal and related cancers
- Viral gastroenteritis research and epidemiology
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Systemic Sclerosis and Related Diseases
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Analysis
- Cardiac and Coronary Surgery Techniques
- Atrial Fibrillation Management and Outcomes
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Muscle and Compartmental Disorders
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Erythropoietin and Anemia Treatment
- SARS-CoV-2 detection and testing
- Morinda citrifolia extract uses
- Viral Infections and Vectors
- Otitis Media and Relapsing Polychondritis
- Connective Tissue Growth Factor Research
- Restless Legs Syndrome Research
Hubei University of Science and Technology
2025
Beijing Center for Disease Prevention and Control
2022-2024
Capital Medical University
2019-2024
Shandong University
2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Beijing Sanbo Brain Hospital
2023-2024
Dalian Medical University
2014-2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Guangzhou University of Chinese Medicine
2023
Respiratory syncytial virus (RSV) has posed substantial morbidity and mortality burden to young children older adults globally. The coronavirus disease 2019 (COVID-19) pandemic was reported have altered RSV epidemiology could important implications for prevention control strategies. We aimed compare in different phases of the COVID-19 with pre-pandemic period by leveraging epidemiological, molecular, serological data collected from a prospective respiratory pathogen surveillance serology study.
Abstract The GDF11 expression pattern and its effect on organ regeneration after acute injury in the elderly population are highly controversial topics. In our study, GDF11/8 increased kidney ischemia–reperfusion (IRI), relatively lower level of kidneys aged mice was associated with a loss proliferative capacity decline renal repair, compared to young mice. vivo , supplementation vimentin Pax2 as well percentage 5-ethynyl-2′-deoxyuridine (EdU)-positive proximal tubular epithelial cells....
Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). We have previously demonstrated low expression miR-133b in MSC-derived extracellular vesicles (MSC-EVs) aged rats. However, can mediate the inhibition epithelial-mesenchymal transition (EMT) tubules induced transforming growth factor-β1 (TGF-β1). investigated effect for treatment geriatric fibrosis evaluated its target genes.We performed...
Background: One-third of intractable epilepsy patients have no visually identifiable focus for neurosurgery based on imaging tests [magnetic resonance (MRI)-negative cases]. Stereo-electroencephalography-guided radio-frequency thermocoagulation (SEEG-guided RF-TC) is utilized in the clinical treatment to lower incidence complications post-open surgery. Objective: This study aimed identify prognostic factors and long-term seizure outcomes SEEG-guided RF-TC with MRI-negative epilepsy. Design:...
Background Heparin-induced thrombocytopenia is an immune response mediated by anti-PF4/heparin antibody, which clinically characterized and thromboembolic events. In this study, a prospective multi-center clinical investigation determined the positive rate of antibody in maintenance hemodialysis patients China, identified related risk factors, further explored effect on bleeding, events, death patients. Methods The serum was measured 661 from nine centers, detected IgG-specific ELISA...
Background: The incidence of chronic kidney disease (CKD) and end-stage (ESKD) is increasing worldwide. Hemodialysis (HD) the mainstay renal replacement therapy for patients with ESKD. Risk factors associated late arteriovenous fistula (AVF) failure in HD are poorly investigated. Therefore, aim this study was to identify AVF patients. Methods: Patients (ESRD) who underwent forearm or upper arm angioplasty at Second Affiliated Hospital Chongqing Medical University between September 2009...
The crosstalk between glioma cells and astrocytes plays a crucial role in developing temozolomide (TMZ) resistance of glioblastomas, together with the existence BBB contributing to unsatisfactory clinical treatment glioblastomas. Herein, we developed borneol-modified gastrodin-loaded liposome (Bo-Gas-LP), intent enhancing efficacy TMZ therapy after intranasal administration. results showed that Bo-Gas-LP improved GL261 cells' sensitivity prolonged survival GL261-bearing mice by blocking...
Abstract Aims Deep brain stimulation (DBS) of the anterior nucleus thalamus, is an effective therapy for patients with drug‐resistant epilepsy, yet, its mechanism action remains elusive. Adenosine kinase (ADK), a key negative regulator adenosine, potential modulator epileptogenesis. DBS has been shown to increase adenosine levels, which may suppress seizures via A1 receptors (A 1 Rs). We investigated whether could halt disease progression and involvement mechanisms. Methods Control group, SE...
Background and Aims: Patients with heart failure reduced ejection fraction (HFrEF) are among the most challenging patients undergoing coronary artery bypass grafting surgery (CABG). Several surgical risk scores commonly used to predict in CABG. However, these do not specifically target HFrEF patients. We aim develop validate a new nomogram score of in-hospital mortality after Methods: The study retrospectively enrolled 489 who had underwent outcome was postoperative death. About 70% (n =...
Background Anticoagulation treatments are an important aspect of hemodialysis; however, few reports have addressed these treatments. This investigation intends to increase the understanding current status and improvements hemodialysis-related anticoagulation in China. Methods In this study, epidemiological was conducted that examined 842 patients 2007 1 175 2012 who underwent hemodialysis seven blood purification centers northern Chinese cities. Results Heparin most commonly used...
To investigate the epidemiological and clinical characteristics of RSV among patients aged ≥60 years in Beijing from 2015 to 2023.
Abstract Background and Aims Non-alcoholic fatty liver disease (NAFLD) is a progressive that ranges from simple steatosis to inflammation, fibrosis, cirrhosis. To address the unmet need for new NAFLD biomarkers, we aimed identify candidate biomarkers using publicly available RNA sequencing (RNA-seq) proteomics data. Methods An approach involving unsupervised gene clustering was performed homogeneously processed integrated RNA-seq data of 625 specimens screen in combination with public...
Background: Rhabdomyolysis (RM) is a clinical syndrome characterized by breakdown of skeletal muscle fibers and release their contents into the circulation. Myoglobin-induced acute kidney injury (AKI) one most severe complications RM. Based on our previous research, exogenous biological renal support alleviates ischemia–reperfusion in elderly mice. This study aimed to determine whether promotes recovery from RM-induced AKI preliminarily explore mechanisms involved. Methods: A parabiosis...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> Oral fluids (OFs) have been broadly used as non-invasive samples for evaluating protective IgG antibodies from natural infection or vaccination, especially in pediatric populations. </sec><sec> <b>Methods</b> Paired OF and serum were collected both individuals who received a booster dose of the inactive coronavirus disease 2019 (COVID-19) vaccine well those did not history COVID-19 vaccination (as control group). The total human...