A5043502416- Ubiquitin and proteasome pathways
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Breastfeeding Practices and Influences
- Virus-based gene therapy research
- Diabetes Management and Research
- Autophagy in Disease and Therapy
- Viral gastroenteritis research and epidemiology
- Obesity, Physical Activity, Diet
- Respiratory viral infections research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Healthcare Systems and Challenges
- Sleep and related disorders
- School Health and Nursing Education
- Emergency and Acute Care Studies
- Genetics and Neurodevelopmental Disorders
- Cystic Fibrosis Research Advances
- Obesity and Health Practices
- Neurological diseases and metabolism
- Indigenous Health, Education, and Rights
University of Auckland
2011-2024
St. Paul's Hospital
2024
University of British Columbia
2024
Cancer Society of New Zealand
2004-2011
Stanford University
2001-2004
Australian National University
1997-2001
Singleton Hospital
2000
Abstract Background Vitamin D has immune‐modulating effects. We determined whether vitamin supplementation during pregnancy and infancy prevents aeroallergen sensitization primary care respiratory illness presentations. Methods A randomized, double‐blind, placebo‐controlled parallel‐group trial. assigned pregnant women, from 27‐week gestation to birth, then their infants, birth 6 months, placebo or one of two dosages daily oral D. Woman/infant pairs were randomized to: placebo/placebo, 1000...
Ubiquitin is a small eukaryotic protein that synthesized naturally as one of several fusion proteins, which are processed by ubiquitin-specific proteases to release free ubiquitin. The expression heterologous proteins fusions ubiquitin in either prokaryotic or hosts often dramatically enhances their yield, and allows the exposure any amino acid following cleavage single exception when proline immediately ubiquitin; ubiquitin-proline bond poorly cleaved presently studied proteases. We show...
Pregnant women routinely receive information in support of or opposing infant immunization. We aimed to describe immunization sources future mothers' and determine if receiving is associated with timeliness.We analyzed data from a child cohort born 2009-2010 New Zealand. (N = 6822) at median gestation 39 weeks described encouraging discouraging Immunizations received by infants were determined through linkage the National Immunization Register (n 6682 6853 [98%]). Independent associations...
In children, community-acquired pneumonia is a frequent cause of emergency department (ED) presentation and hospital admission. Quality primary care may prevent some these visits. The aim this study was to identify factors associated with ED admission preschool-aged children pneumonia. A case–control conducted by enrolling three groups: presenting the admitted (n=326), or discharged home (n=179), well-neighbourhood controls (n=351). Interviews parents staff were health record review...
Pertussis immunization programs aim to prevent severe infant disease. We investigated temporal trends in pertussis deaths and pediatric intensive care unit (PICU) admissions associations of changes disease detection vaccines used with death PICU admission rates.Using national data from New Zealand (NZ), we described 1991 2013, over which time coverage at 2 years age increased <80% 92%. In NZ, became a notifiable polymerase chain reaction (PCR) diagnosis available 1997 acellular replaced...
The ubiquitin‐proteasome system (UPS) is a central component in the cellular defence against potentially toxic protein aggregates. UPS dysfunction linked to pathogenesis of both sporadic and inherited neurodegenerative diseases, including dominantly familial amyotrophic lateral sclerosis (fALS). To investigate role fALS pathogenesis, transgenic mice expressing mutant G93A Cu,Zn superoxide dismutase (SOD1) were crossed with epitope tagged, wild‐type or dominant‐negative ubiquitin (Ub K48R )....
Infectious diseases are the leading cause of hospital admissions in young children. Hospitalisation with an infectious disease is a recurrent event for some Our objective was to describe risk factors readmission following admission first two years life.We performed national cohort study New Zealand children, born 2005-2009, before age 24 months. Children readmitted within 12 months were identified. Every categorised as respiratory, enteric, skin and soft tissue, urinary or other infection....
Abstract Aim The incidence of childhood empyema has been increasing in some developed countries despite the introduction pneumococcal vaccination. This study aimed to document incidence, bacterial pathogens, and morbidity/mortality parapneumonic effusion/empyema New Zealand. Methods A prospective 102 children <15 years age requiring hospitalization with between May 1, 2014 31, 2016 notified via Zealand Paediatric Surveillance Unit. Parapneumonic was defined as pneumonia pleural effusion...
To determine if the routine use of automatically calculated birthweight centiles prior to discharge from delivery unit is associated with improved adherence neonatal hypoglycaemia guideline.We conducted retrospective audits guideline in a tertiary maternity hospital Auckland, New Zealand randomly selected cohort newborn infants at risk before (2011) and after (2015) introduction for all infants. The primary outcome was guideline, defined as (i) blood glucose concentration screening first 48...
The information fathers receive about infant vaccination may influence their decision to vaccinate. We describe fathers' sources of and paternal determinants timely vaccinations. Participants were from a child cohort study in New Zealand. was established by enrolling pregnant women partners. During pregnancy, (n = 4017) the children born 2009-2010 described that encouraged or discouraged vaccination. National Immunization Register provided data. Independent associations received with...
Whānau Pakari is a healthy lifestyle assessment and intervention programme for children adolescents with obesity in Taranaki (Aotearoa/New Zealand), which, this region, replaced the nationally funded Green Prescription Active Families (GRxAF) programme. We compared national referral rates from GRxAF (age 5-15 years) B4 School Check (B4SC, preschool health development assessment) Pakari. retrospectively analysed 5 years of clinical data (2010-2015), comparing before, during, after trial,...
Following trials of inhaled antibiotics in adults, this study investigates the efficacy nebulised gentamicin to improve respiratory function children with bronchiectasis.This is a randomised, double-blind, placebo-controlled, crossover trial 12-week placebo/gentamicin, 6-week washout, gentamicin/placebo. Participants were (5-15 years) bronchiectasis, chronic infection (any pathogen), and able perform spirometry from hospital bronchiectasis clinic. Primary outcomes change forced expiratory...