A5082836813- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Cancer-related gene regulation
- Legume Nitrogen Fixing Symbiosis
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Plant Stress Responses and Tolerance
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Medical Imaging Techniques and Applications
- Hepatitis C virus research
- Plant-Microbe Interactions and Immunity
- Lung Cancer Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Plant Disease Resistance and Genetics
- Atomic and Subatomic Physics Research
- Plant nutrient uptake and metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cellular transport and secretion
- Zebrafish Biomedical Research Applications
- Plant responses to water stress
- Developmental Biology and Gene Regulation
- Mycotoxins in Agriculture and Food
- Plant Gene Expression Analysis
- Nuclear Physics and Applications
- Medicinal Plants and Neuroprotection
Chinese Academy of Forestry
2020-2025
Nanjing Agricultural University
2022-2025
COMSATS University Islamabad
2024
Dalian Medical University
2011-2021
Second Affiliated Hospital of Chongqing Medical University
2011-2021
Chongqing Medical University
2011-2021
Nanjing Forestry University
2021
Research Institute of Forestry
2021
Stanford University
2014
University of Massachusetts Amherst
1998-2002
Background The Hepatitis C virus (HCV) core protein has been implicated as a potential oncogene or cofactor in HCV-related hepatocellular carcinoma (HCC), but the underlying mechanisms are unknown. Overactivation of Wnt/β-catenin signaling is major factor oncogenesis HCC. However, pathogenesis HCV core-associated activation remains to be further characterized. Therefore, we attempted determine whether plays an important role regulating HCC cells. Methodology activity was investigated...
Hepatocellular carcinoma (HCC) is one of the most deadly cancers. Aberrant oncogenic activation Wnt/β-catenin signaling pathway contributes to hepatocellular carcinogenesis. Various epigenetic modifications Wnt antagonist secreted frizzled-related protein (SFRP) family have been implicated in regulating signaling. Here, we report that Hepatitis C virus (HCV) core downregulates SFRP1 expression when it expressed Huh7 and HepG2 cells. can be effectively restored by using either a DNA...
Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis. However, dysregulation SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never studied HBV-related hepatocellular carcinoma (HBV-HCC). In this study, we sought determine clinical significance and underlying mechanism HBx-induced hepatoma cells HBV-HCC patients. Our results showed that SFRP1 SFRP5 expression...
Glued 1 ( Gl ) mutants produce a truncated protein that acts as poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous have axonal defects in adult eye nervous system. Here we show selective expression of neurons giant fiber (GF) system disrupts synaptogenesis between GF one its targets, tergotrochanteral motorneuron (TTMn). Growth pathfinding by axon TTMn dendrite are normal, but terminal fails to develop normally becomes swollen with large vesicles. This is...
Abstract Several species of soil free‐living saprotrophs can sometimes establish biotrophic symbiosis with plants, but the basic biology this association remains largely unknown. Here, we investigate symbiotic interaction between a common saprotroph, Clitopilus hobsonii (Agaricomycetes), and American sweetgum ( Liquidambar styraciflua ). The colonized root cortical cells were found to contain numerous microsclerotia‐like structures. Fungal colonization led increased plant growth facilitated...
Soil salinity caused by NaCl is a major challenge to agricultural crops worldwide. For this, two WRKY transcription factors were evaluated for their role in salt stress tolerance tomato plants (Solanum lycopersicum; Sl). SlWRKY36 and SlWRKY51 provided novel insight into the regulatory mechanism against via virus-induced gene silencing (VIGS). Salt significantly reduced chlorophyll-a, an abundant form of chlorophyll content 6.0 5.1 mg/g proline 0.06 0.09 respectively silenced plants. This...
Long noncoding RNAs (lncRNAs) have emerged as pivotal regulators in plant immune responses, yet their roles rice resistance against Magnaporthe oryzae (M. oryzae) remain inadequately explored. In this study, we integrated translatome data with conventional genome annotations to construct an optimized protein-coding dataset. Subsequently, developed a robust pipeline (“RiceLncRNA”) for the accurate identification of lncRNAs. Using strand-specific RNA sequencing (ssRNA-seq) from resistant...
Fusarium species, recognised as global priority pathogens, frequently induce severe diseases in crops; however, certain species exhibit alternative symbiotic lifestyles and are either non-pathogenic or endophytic. In this study, we characterised the mutualistic relationship between eFp isolate of F. pseudograminearum five poplar resulting formation root structures reminiscent ectomycorrhizal (ECM) symbiosis. This functional symbiosis is evidenced by enhanced plant growth, reciprocal nutrient...
The Roundabout (Robo) receptors have been intensively studied for their role in regulating axon guidance the embryonic nervous system, whereas a dendritic has not explored. In adult giant fiber system of <i>Drosophila</i>, we revealed that ectopic Robo expression can regulate growth and specific motor neuron dendrites, Robo2 Robo3 no effect. We also show effect on be suppressed by Commissureless coexpression. Although confirmed all three guidance, strong alterations caused overexpression or...
The classification and identification of species in
Potato is one of the highly consumed vegetable crop grown in different regions across Pakistan that affected by fungal diseases. The current research was conducted to identify pathogen causing mold-like disease potato Khyber Pakhtunkhwa (KP), Pakistan. For molecular identification and characterization disease; tuber samples were collected followed culturing on dextrose agar (PDA). Based morphological features, identified as a Penicillium species. This result obtained 45 isolates from tubers....
Genus Fusarium (Ascomycota, Hypocreales, Nectriaceae) includes many economically important plant pathogens that cause devastating diseases of a wide range crops and trees. Interestingly, there is increasing evidence some species also live as endophytes benefit growth stress tolerance. In this work, we sequence the whole genomes endophytic F. culmorum pseudograminearum, isolated from coastal dunegrass (Leymus mollis), using long-read single-molecule real-time sequencing technology. Their are...
Clitopilus hobsonii (Entolomataceae, Agaricales, Basidiomycetes) is a common soil saprotroph. There also evidence that C. can act as root endophyte benefitting tree growth. Here, we report the genome assembly of QYL-10, isolated from ectomycorrhizal tips Quercus lyrata. The size 36.93 Mb, consisting 13 contigs (N 50 = 3.3 Mb) with 49.2% GC content. Of them, 10 approached length intact chromosomes, and three had telomeres at one end only. BUSCO analysis reported completeness score 98.4%,...
Symbiotic association Rhizobium astragali with barley roots was induced by a permanent magnetic field. Initially root hairs were deformed. Later, pseudonodules formed, showing infected cells infection threads, and bacteroids each enclosed within peribacteroid membrane. The overall picture is similar to that of legume nodules. No acetylene reduction activity could be detected in pseudonodules.
<title>Abstract</title> Potato tubers collected from different areas showed the prevalence of dry rot with characteristic white mycelia <italic>Fusarium</italic> pathogen. species on diseased were isolated based morphological features. 18S-ITS analysis followed by Phylogenetic tree constructed using TEF1-α identified isolates as <italic>Fusarium verticilloides</italic>, soloni</italic>, oxysporum</italic> and falciforme</italic>. According to our knowledge, this study is first report...
Purpose: We propose a novel lung functional imaging method to determine the spatial distribution of xenon (Xe) gas in single inhalation as measure regional ventilation. compare Xe‐CT ventilation single‐photon emission CT (SPECT) ventilation, which is current clinical reference. Regional information may be useful for diagnosis and monitoring pulmonary diseases such COPD, radiotherapy planning, assessing progression toxicity after radiation therapy. Methods: In an IRB‐approved study, SPECT...
To investigate the biological function of hepatitis C virus (HCV)-encoded F protein in hepatocytes.The full-length gene was amplified by PCR from HCV genotype 1a and cloned into plasmid pSEB-3Flag restriction enzyme digestion ligation. Hepatoma cell lines, Huh7 SMMC7721, were transfected with resultant recombinant pSEB-3Flag-F or original (negative control) screened selective antibiotic, blasticidin. Stable expression verified RT-PCR analysis. Analysis growth cycle carried out MTS assay,...