A5054266587- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Neurogenetic and Muscular Disorders Research
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Protease and Inhibitor Mechanisms
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Bone health and treatments
- RNA Research and Splicing
- Genetics and Physical Performance
- Diabetes and associated disorders
- Peptidase Inhibition and Analysis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Cardiovascular Effects of Exercise
- Knee injuries and reconstruction techniques
- Cytokine Signaling Pathways and Interactions
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
Universidade da Coruña
2019-2024
Instituto de Investigación Biomédica de A Coruña
2019-2024
Complexo Hospitalario Universitario A Coruña
2019-2024
To analyze the influence of mitochondrial genome variation on DNA methylome articular cartilage.DNA methylation profiling was performed using data deposited in NCBI Gene Expression Omnibus database (accession no. GSE43269). Data were obtained for 14 cartilage samples from subjects with haplogroup J and 20 H. Subsequent validation an independent subset 7 9 H by RNA-seq. Correlated genes validated real-time polymerase chain reaction cohort 12 Appropriate analyses R Bioconductor qBasePlus...
The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship OA metabolic syndrome, suggests that there are systemic factors related disorders involved phenotype of OA. aim this work is study effects palmitate oleate on cellular metabolism an “ vitro ” model human chondrocytes. TC28a2 chondrocyte cell line was used analyze effect mitochondrial glycolytic function, Adenosine triphosphate (ATP) production lipid droplets...
Abstract Background Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model stratify patients at an early stage according risk of joint structure disease progression. Some genetic factors, including single nucleotide polymorphism (SNP) genes mitochondrial (mt)DNA haplogroups/clusters, have been linked this For first time, aim determine, by using machine learning,...
Abstract To evaluate the influence of mitochondrial DNA haplogroups on risk knee OA in terms their interaction with obesity, a population from Mexico. Samples were obtained (n = 353) patients (KL grade ≥ I) and 364) healthy controls 0) Mexico city Torreon (Mexico). Both Caucasian Amerindian mtDNA assigned by single base extension assay. A set clinical demographic variables, including obesity status, considered to perform appropriate statistical approaches, chi-square contingency tables,...
<h3>Background:</h3> There is a pressing need to identify patients prone suffer the rapidly progressive knee osteoarthritis phenotype (RPKOA) in order implement preventive strategies and include them clinical trials. However, overlapping with risk factors of normal progression makes search for specific rapid challenging. <h3>Objectives:</h3> To decipher molecular patterns that allow specifically differentiate between non-rapid progressors from OAI. <h3>Methods:</h3> This study included...
In the context of cytokine storm takes place in severe COVID-19 patients,
<h3>Background</h3> Erosive hand osteoarthritis (OA) is considered a more severe form of OA that includes pain and inflammation (1,2). However, data are needed regarding the different phenotypes, especially erosive non-erosive, to conclude if they represent two subsets or even degrees affectation same disease (1,3,4) <h3>Objectives</h3> To compare clinical pattern patients with those do not show this phenotype <h3>Methods</h3> The study was conducted in Prospective Cohort Osteoarthritis A...
<h3>Background:</h3> There is a pressing need to identify individuals with accelerated osteoarthritis include them in clinical trials and implement prevention strategies. During the last years, mtDNA haplogroups have been consistently associated OA terms of genetic factors influencing both incidence progression disease (1,2) <h3>Objectives:</h3> To analyze influence on risk rapid knee patients from Osteoarthritis Initiative (OAI). <h3>Methods:</h3> We selected Caucasian OAI that were...
Background: There is a need to identify patients with the rapid progressive phenotype of Osteoarthritis (RPOA) include them in clinical trials and implement prevention strategies. During last years, nuclear single nucleotide polymorphisms (SNPs) were associated susceptibility progression disease, but not phenotype. Objectives: Analyze influence previously knee OA-associated SNPs on risk RPOA OAI. Methods: Caucasian from OAI selected assigned into three different groups (N=252/group) based...
Background The development of a tool capable identifying patients suffering the rapid progressive knee Osteoarthritis (RPOA) was established as goal to implement prevention strategies and include them in clinical trials. Previous studies showed that mitochondrial DNA (mtDNA) variation plays role on incidence progression OA, but their influence RPOA is unknown. Objectives To find new mtDNA variants related order develop predictive model based genetic variables. out functional significance...
Background: The early identification of patients with rapid progressive osteoarthritis (RPOA) could allow the implementation prevention strategies and their inclusion in clinical trials. Polymorphisms nuclear mitochondrial DNA (mtDNA) have been associated OA. Preliminary analyses by our group showed single nucleotide polymorphism (nSNP) rs12107036 TP63 as a potential risk factor for RPOA knee. Objectives: i) To analyze interactions between mtDNA haplogroups ii) apply Next Generation...