A5079281691- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Advanced Biosensing Techniques and Applications
- Inflammatory mediators and NSAID effects
- HIV-related health complications and treatments
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- S100 Proteins and Annexins
- Systemic Lupus Erythematosus Research
- Protein purification and stability
- Chemokine receptors and signaling
- Neurogenetic and Muscular Disorders Research
Instituto de Investigación Biomédica de A Coruña
2019-2024
Complexo Hospitalario Universitario A Coruña
2019-2024
Servicio Gallego de Salud
2019-2024
Universidade da Coruña
2021-2022
Objective Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management patients using preventative strategies. We develop and validate a prognostic model useful predicting incidence radiographic KOA (rKOA) non-radiographic osteoarthritic subjects stratify individuals at high risk developing disease. Methods Subjects without signs according to Kellgren Lawrence (KL) classification scale (KL=0 both knees) were enrolled OA initiative (OAI) cohort...
Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human osteoarthritic tissue, which may serve as disease markers. With aim, secretomes and healthy cartilages obtained knee hip were analyzed shotgun peptidomics. This discovery step led identification 1175 different peptides, corresponding 101 proteins, products physiological or pathological...
To gain new insight into the molecular changes of meniscus by comparing proteome profiles healthy controls with mild degeneration and end-stage osteoarthritis (OA).We obtained tissue plugs from lateral medial menisci 37 individuals (central part posterior horn) classified as (n = 12), signs joint damage 13) OA 12). The protein profile was analysed nano-liquid chromatography-mass spectrometry using data-independent acquisition quantified Spectronaut. Linear-mixed effects modelling applied...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence systemic autoantibodies, with a great clinical molecular heterogeneity. Factor (RF) anti-citrullinated protein antibodies (ACPA) are routinely used for diagnosis RA. However, additional serological markers needed to improve management this disease, allowing better patient stratification desirable application precision medicine strategies. In present study, we investigated those...