A5068978904- Biocrusts and Microbial Ecology
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Computational Drug Discovery Methods
- Slime Mold and Myxomycetes Research
- Microbial Community Ecology and Physiology
- Algal biology and biofuel production
- HIV-related health complications and treatments
- Plant Gene Expression Analysis
- Synthesis and biological activity
- Pulmonary Hypertension Research and Treatments
- Plant and Biological Electrophysiology Studies
- Cardiovascular Disease and Adiposity
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Salmonella and Campylobacter epidemiology
- Disaster Response and Management
- Enzyme Structure and Function
- Vitamin C and Antioxidants Research
- Protist diversity and phylogeny
- Drug-Induced Hepatotoxicity and Protection
- Vitamin K Research Studies
- Atherosclerosis and Cardiovascular Diseases
Northeastern Illinois University
2019-2024
Indianapolis Zoo
2022
Indiana University School of Medicine
2021
Indiana University
2021
University of Wisconsin–Milwaukee
2019
Japan Synchrotron Radiation Research Institute
2019
University of Chicago
2019
Kyoto University
2019
University of Gothenburg
2019
SPring-8
2019
Phytochromes (PHYs) are photoreceptor proteins first discovered in plants, where they control a variety of photomorphogenesis events. PHYs as photochromic can reversibly switch between two distinct states: red light (Pr) and far-red (Pfr) absorbing form. The discovery Bacteriophytochromes (BphPs) nonphotosynthetic bacteria has opened new frontiers our understanding the mechanisms by which these natural photoswitches single cell development, although role BphPs vivo remains largely unknown....
Phytochromes are sensory photoreceptors that use light to drive protein structural changes, which in turn trigger physiological reaction cascades. The process starts with a double-bond photoisomerization of the linear methine-bridged tetrapyrrole chromophore photosensory core module. molecular mechanism photoconversion depends on and electrostatic properties environment, highly conserved related phytochromes. However, specific role individual amino acids is yet not clear. A histidine...
Abstract There is an urgent need for anti-viral agents that treat and/or prevent Covid-19 caused by SARS-Coronavirus (CoV-2) infections. The replication of the SARS CoV-2 dependent on activity two cysteine proteases, a papain-like protease, PL-pro, and 3C-like protease known as main Mpro or 3CLpro. shortest safest path to clinical use repurposing drugs with binding affinity PLpro 3CLpro have established safety profile in humans. Several studies reported crystal structures SARS-CoV-2 complex...
Abstract The SARS coronavirus 2 main protease 3CLpro tailor cuts various essential virus proteins out of long poly-protein translated from the RNA. If is inhibited, functional cannot form and replicate assemble. Any compound that inhibits therefore a potential drug to end pandemic. Here we show diffraction power crystals effectively destroyed by Ebselen. It appears Ebselen may be widely available, relatively cost effective way eliminate 2.
Abstract Phytochromes are red/far-red light photoreceptors in bacteria to plants, which elicit a variety of important physiological responses. They display reversible photocycle between the resting (dark) Pr state and activated Pfr state, signals received transduced as structural change through entire protein modulate activity protein. It is unknown how Pr-to-Pfr interconversion occurs structure intermediates remain notoriously elusive. Here, we present short-lived crystal structures...
Introduction: People living with HIV experience increased cardiovascular comorbidities despite immediate prescription of combined antiviral therapy (ART) upon diagnosis. Previously, we reported that the virally encoded HIV-Nef protein persists in extracellular vesicles (EV) aviremic patients on ART and endothelial-specific transgenic expression murine models causes endothelial surface pro-apoptotic EMAPII. Co-culture expressing T cells induced senescence which could be completely abrogated...
Rationale: People living with HIV experience increased rates of cardiovascular co-morbidities including pulmonary hypertension (600-fold higher prevalence) despite immediate prescription combined antiviral therapy (ART) upon diagnosis. Previously, we reported that the virally encoded HIV-Nef protein persists in extracellular vesicles (EV) isolated from bronchoalveolar lavage fluid aviremic patients on ART. Interestingly, Nef-positivity correlated EMAPII levels, a cellular which when released...
Introduction: Migration of leukocytes in response to chemical gradients, chemotaxis, is dependent on many factors, including cell type, surface markers, the chemoattractant, etc. Sphinogsine-1-phosphate (S1P) a chemoattractant playing large role migrating activated T cells out lymph nodes by binding their S1P receptor, S1P1. The importance egress from highlighted pharmacological disruption this migration can lead immune dampening and thus control multiple sclerosis, an autoimmune disease. In...