A5077395016- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Enterobacteriaceae and Cronobacter Research
- Microbial Inactivation Methods
- Probiotics and Fermented Foods
- Polyomavirus and related diseases
- Fungal and yeast genetics research
- Cell Image Analysis Techniques
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Genetics and Neurodevelopmental Disorders
- Protein Degradation and Inhibitors
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- Autophagy in Disease and Therapy
University of Michigan
2023-2024
Michigan Center for Translational Pathology
2023
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding mechanisms governing ERMCS regulation their roles in metabolism limited by lack tools that permit temporal induction reversal. Through unbiased screening approaches, we identified fedratinib, an FDA-approved drug, dramatically increases abundance...
BK polyomavirus (BKPyV) is a human pathogen that infects nearly everyone by adulthood and persists throughout person’s life. Only people with significant immune suppression develop disease from the virus, however.
Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate resistance to common antifungal therapies. Additionally, there host toxicity associated with many compounds due conservation between essential mammalian and fungal proteins. An attractive new approach for antimicrobial development target virulence factors: non-essential processes that are required organism disease in hosts. This expands potential space while...
Abstract Dengue Virus (DENV) causes dengue fever, a pandemic-potential disease with currently no FDA-approved antivirals. Additionally, the available vaccine for DENV can increase risk of severe fever those who have never had infection due to antibody-dependent enhancements. Thus, there is an urgent need identify virus Antivirals that target NS4B, replication compartment forming protein and flavivirus family, are promising new drug class minimize cytotoxic effects host cells....
Fungal pathogens like