A5023636277- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Optical Network Technologies
- Advanced Photonic Communication Systems
- Advanced Fiber Optic Sensors
- Nail Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Oral Health Pathology and Treatment
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Dermatologic Treatments and Research
- Chemotherapy-related skin toxicity
- Spondyloarthritis Studies and Treatments
- Cancer and Skin Lesions
- Skin Diseases and Diabetes
- Inflammatory Myopathies and Dermatomyositis
- Urticaria and Related Conditions
- Magneto-Optical Properties and Applications
- Photonic Crystals and Applications
- Contact Dermatitis and Allergies
- Advanced Fiber Laser Technologies
- Microfluidic and Capillary Electrophoresis Applications
Tohoku University
2016-2025
Sendai City Hospital
2015
NTT (Japan)
1988-2009
NTT (United States)
2002
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inflammation of various organs such as skin, kidneys, bones, and brain the presence autoantibodies. Although cause SLE not completely understood, environmental factors, genetic susceptibility, hormone factors are thought to play essential roles in pathogenesis SLE. Among microbiota linked development different diseases. The nasal cavity gut involved development, but influence skin still unclear. Here, we...
Here, a novel porous microneedle (PMN) device with bilaterally aligned electroosmotic flow (EOF) enabling controllable dual-mode delivery of molecules is developed. The PMNs placed at anode and cathode compartments are modified anionic poly-2-acrylamido-2-methyl-1-propanesulfonic acid cationic poly-(3-acrylamidopropyl) trimethylammonium, respectively. direction EOF generated by PMN the compartment is, therefore, reversed from to anode, countering unwanted cathodal suctioning interstitial...
The authors have fabricated an optical WDM module with a simple configuration using PLC platform together spot-size converted LD (SS-LD) and waveguide PD (WG-PD). Since the can be formed simply by flip-chip bonding of SS-LD WG-PD, this reduces number components, thus helps achieve cost reduction.
La and Ga substituted yttrium iron garnet single-mode buried channel waveguides, prepared using liquid-phase-epitaxial growth Ar ion beam etching, have been successfully applied as 45/spl deg/ nonreciprocal waveguide rotators (NRWR) for hybrid integrated isolators at /spl lambda/=1.55 mu/m. The optical magneto-optical properties of the NRWRs epitaxial films are investigated in detail. We describe assembly procedure present measurement results isolators. composed a NRWR, half-wave plate...
An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose this study was to identify cellular by which LL-37 amplifies inflammation induced damage-associated molecular patterns (DAMPs). We performed DNA microarray, reverse transcription polymerase chain reaction, immunoblotting, proximity ligation assays using cultured keratinocytes treated with and/or DAMP poly(I:C), a synthetic...
We fabricated a new type of waveguide polarization-independent optical circulator which does not need polarization-beam splitter. The is based on non-reciprocal Mach-Zehnder interferometer consists two Faraday rotators, thin-film half-waveplates and planar lightwave circuit-type 3-dB couplers. provides 14.0-23.7-dB isolation 3.0-3.3 dB insertion loss at /spl lambda/=1.55 μm. This presents possibility for developing devices in the field integrated optics.
A two-step bonding technique for optical device assembly on a planar lightwave circuit platform was developed, which consists of chip-by-chip thermo-compression prebonding step and simultaneous reflow step. The used to realize multichip integration the platform. characteristics were examined by investigating its strength accuracy. accuracies in horizontal vertical directions 1.1 0.8 /spl mu/m, respectively, with high strength. first applied 3 chip integrated transceiver module 136 fabricated...
Bending loss of high-silica single-mode bending optical waveguides using a waveguide side-wall as reflecting facet is described theoretically and experimentally function the angle. Two types waveguides, which have exposed to air coated with metal film, are treated. The causes discussed in terms los due Goos-Hanchen effect perpendicularity roughness facet.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated consist type 1 helper T cells, but no detailed phenotypical analysis other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous BCC. present case, investigated immunohistochemical profiles TILs, not only focusing on cytotoxic immunosuppressive...
The fabrication and characteristics of a hybrid-integrated optical gate matrix switch were studied. was composed silica-based single-mode guided-wave circuit two InGaAsP array chips, each which comprised eight laser diode gates. chips assembled on the using hybrid integration technique. insertion loss fabricated 4*4 scattered among switching paths ranged from 26 to 33 dB. applicable 400 Mb/s signal system with bit error rate 10/sup -9/. numerical analysis shows that residual reflectivity at...
A 2 × nonblocking optical matrix switch, composed of four elemental switches formed in a slab waveguide, is described. Switching action based on total internal reflection caused by an electrically controlled change refractive index the liquid crystal. Propagation loss was remarkably reduced to 2.3 dB/cm, both using crystal as cladding layer and operating at 1.31 μm wavelength. The experimental switch exhibited 7.3-7.7 dB insertion loss, -17.3 -18.2 crosstalk, 14° switching angle.
Enforced enrichment of the active promoter marks trimethylation histone H3 lysine 4 (H3K4me3) and acetylation 27 (H3K27ac) by inhibiting demethylases deacetylases is positively associated with hard tissue formation through induction osteo/odontogenic differentiation. However, key endogenous epigenetic modulator odontoblasts to regulate expression genes coding dentin extracellular matrix (ECM) proteins has not been identified. We focused on nuclear factor (NF)–κB inhibitor ζ (IκBζ), which was...
An index alignment technique was developed for a planar lightwave circuit platform. The successfully applied to the hybrid integration of spot-size converted laser diode on fabricated modules exhibited an average coupling loss 4.2 dB and maximum optical output power 10 mW at injection current 70 mA.
Abstract Rhododendrol ( RD ), 4‐(4‐hydroxyphenyl)‐2‐butanol, inhibits melanin synthesis and has been used for skin‐whitening cosmetic products. very effective in lightening skin pigmentation, but some persons have developed so‐called vitiligo, which vitiligo starts on the face, neck hands where topical applied even extended over areas not applied. lesions patients lasted years resistant to conventional treatments. We examined effects of cholecalciferol a blinded randomized clinical trial....
An optical gate matrix switch that is made by integrating InGaAsP laser diode gates with high-silica guided-wave splitter and combiner circuits in a hybrid fashion proposed demonstrated. It provides point-to-multipoint switching. A preliminary experiment for 4*4 shows the capable of more than 400-Mb/s bandwidth signal switching.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Milia en plaque (MEP) is an uncommon disorder characterized by erythematous containing numerous milia. The pathogenesis of MEP not clear. authors report a man with on the right retroauricular area, white-yellow cysts varying in size. Histological examination showed that multiple cystic structures at various levels dermis were lined stratified squamous epithelium and contained keratinous material-these findings consistent diagnosis In addition to epidermal cysts, however, lesion consisted...