A5051981250- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Photoreceptor and optogenetics research
- Microtubule and mitosis dynamics
- Planarian Biology and Electrostimulation
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
- FOXO transcription factor regulation
- Caveolin-1 and cellular processes
- Additive Manufacturing and 3D Printing Technologies
- Cell Adhesion Molecules Research
- Amyotrophic Lateral Sclerosis Research
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Innovative Microfluidic and Catalytic Techniques Innovation
State University of New York at Oswego
2025
Southern California Eye Institute
2025
University of Southern California
2025
Harvard University
2021-2022
Harvard Stem Cell Institute
2021
Digital light processing bioprinting favors biofabrication of tissues with improved structural complexity. However, soft-tissue fabrication this method remains a challenge to balance the physical performances bioinks for high-fidelity and suitable microenvironments encapsulated cells thrive. Here, we propose molecular cleavage approach, where hyaluronic acid methacrylate (HAMA) is mixed gelatin methacryloyl achieve high-performance bioprinting, followed by selectively enzymatic digestion...
Failure of central nervous system (CNS) axons to regenerate after injury results in permanent disability. Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed direct target-specific axon regeneration. Here, we demonstrate that applying an external guidance cue form electric field stimulation adult rats optic nerve crush was effective at directing long-distance, retinal ganglion cell...
Cell adhesion to the substrate influences a variety of cell behaviors and its proper regulation is essential for migration, although details molecular pathways regulating during migration are lacking. Rap1 small GTPase that regulates in mammalian cells, as well Dictyostelium discoideum social amoeba, which an established model studying directed migration. In Dictyostelium, controls via effects on mediator talin Ser/Thr kinase Phg2, inhibits myosin II function. Kinase responsive stress B...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron loss accompanied cytoplasmic localization of TDP-43 proteins and their insoluble accumulations. Haploinsufficiency TBK1 has been found to associate with or cause ALS. However, the cell-autonomous mechanisms which reduced activity contributes human pathology remain elusive. Here, we generated cellular model harboring loss-of-function mutations gene editing that deficiency was...
Abstract Cell adhesion to the substrate influences a variety of cell behaviors and its proper regulation is essential for migration, although details molecular pathways regulating during migration are lacking. Rap1 small GTPase that regulates in mammalian cells, as well Dictyostelium discoideum social amoeba, which an established model studying directed migration. In , controls via effects on mediator talin Ser/Thr kinase Phg2, inhibits myosin II function. Kinase responsive stress B (KrsB),...