A5036084412- Renal and related cancers
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Acute Kidney Injury Research
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Organ Donation and Transplantation
- Birth, Development, and Health
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Innovations in Medical Education
- Biochemical and Structural Characterization
- Advances in Oncology and Radiotherapy
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Urological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Pharmacy and Medical Practices
- Skin and Cellular Biology Research
- Congenital Heart Disease Studies
- Innovative Teaching Methods
- Student Assessment and Feedback
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Problem and Project Based Learning
Arkansas State University
2019-2023
New York Institute of Technology
2016-2022
Michigan State University
2020
York University
2020
Massachusetts General Hospital
2013-2015
Harvard University
2010-2011
Northwestern University
2004-2010
The nucleoporin Nup98 gene is frequently rearranged in acute myelogenous leukemia (AML). In most cases this results fusion of the N terminus to DNA binding domain a homeodomain transcription factor. prototype these fusions, Nup98-HOXA9, associated with human AML and induces mouse models. To understand mechanisms by which Nup98-HOXA9 causes AML, we expressed it myeloid cells identified its target genes using high density oligonucleotide microarrays. analysis was performed triplicate confirmed...
Acute kidney injury (AKI) is a common and significant medical problem. Despite the kidney's remarkable regenerative capacity, mortality rate for AKI patients high. Thus, there remains need to better understand cellular mechanisms of nephron repair in order develop new strategies that would enhance intrinsic ability tissue regenerate. Here, using novel, laser ablation-based, zebrafish model AKI, we show collective migration epithelial cells primary early response acute injury. We also cell...
Constructive feedback is an important aspect of medical education to help students improve performance in cognitive and clinical skills assessments. However, for appropriately act on feedback, they must recognize quality have the opportunity practice giving, receiving, acting feedback. We incorporated literacy into a case-based concept mapping small group-learning course. Student groups engaged peer review group-constructed maps provided written Faculty also group used simple rubric assess...
The limb- and heart-specific Tbx5 transcription factor coexpresses with directly binds to the novel PDZ-LIM domain protein, LMP4. LMP4 is distributed in cytoplasm associated actin cytoskeleton. In presence of LMP4, shuttles dynamically between nucleus and, a complex localizes filaments. Nuclear cytoplasmic distribution developing chicken wings suggests functional significance LMP4–Tbx5 interaction. primary epicardial cells, we demonstrate that protein subcellular relocalization can be...
Knowledge integration is an important aspect of education. In clinical education, there emphasis on the basic medical science with practice to provide a higher order comprehension for future physicians. Also importance in education promotion and development professional behaviors (i.e., teamwork interpersonal behavior). We set out design implement weekly, 2 hour educational active learning activity first-year preclinical students foster knowledge promote development. As part our case-based...
New nephron formation (nephrogenesis) ceases in mammals around birth and is completely absent adults. In contrast, postembryonic nephrogenesis well documented the mesonephric kidneys of fishes amphibians. The transient mesonephros reptiles (including birds) replaced by metanephros during embryogenesis. Thus, one may speculate that restricted to kidney. Previous reports have suggested non-avian (hereafter reptiles) continually form nephrons throughout life. We investigated presence adult...
Acute kidney injury, often caused by an ischemic insult, is associated with significant short-term morbidity and mortality, increased risk of chronic disease. The factors affecting the renal response to injury following ischemia reperfusion remain be clarified. We found that Stem cell antigen-1 (Sca-1), commonly used as a stem marker, heavily expressed in tubules adult mouse kidney. evaluated its potential role using Sca-1 knockout mice submitted acute (IRI), well cultured proximal tubular...
Multiple choice questions (MCQs) are frequently used in medical education, and practice commonly requested by students. Automated generation of MCQs board-exam format would potentially save significant time for faculty generate a wider set materials. The goals this study were to explore the feasibility using ChatGPT OpenAI USMLE/COMLEX style quiz items as aids, analyze how what extent students voluntarily use these prepare exams. Researchers gave second year studying renal physiology access...
Vertebrate limb development involves a reciprocal feedback loop between mesenchyme and the overlying apical ectodermal ridge (AER). Several gene pathways participate in this loop, including Fgf signaling. In forelimb lateral plate mesenchyme, Tbx5 activates Fgf10 expression, which turn initiates maintains mesenchyme/AER signaling loop. Recent findings have revealed that transcriptional activity is regulated by dynamic nucleocytoplasmic shuttling interaction with Pdlim7, PDZ-LIM protein...
Abstract Reptile, avian, and mammalian species all possess a metanephric kidney to maintain fluid homeostasis. The physiology of the is intimately related tissue organization gross morphology, which dependent upon organ size, animal habitat, body plan. Reptiles have significant variations in plan as result differences visceral placement morphology. One that appears show great morphological variation reptilian found Crocodylia, Testudines, Squamata (Sauria Ophidia). However, limited research...
Acute Kidney Injury (AKI) is a common medical condition with high mortality rate. With the repair abilities of kidney, it possible to restore adequate kidney function after supportive treatment. However, better understanding how nephron cell death and occur on cellular level required minimize enhance regenerative process. The zebrafish pronephros good model system accomplish this goal because contains anatomical segments that are similar mammalian nephron. Previously, most used study injury...
The mammalian metanephric kidney develops from reciprocal interactions between the mesenchyme and ureteric bud (UB) to give rise a variety of cell types structures including interstitial cells, vasculature, epithelial tubules. Progenitor cells adjacent UB, termed cap (CM), undergo mesenchymal‐to‐epithelial transition (MET) form called renal vesicles before elongating differentiating into nephrons, functional unit kidney. Several genes are expressed in CM that required for proper development....
Context: There is a lack of adequate instructional intervention in the core competencies interprofessionalism and meaningful use electronic health records (EHRs).Evidence demonstrates that medical schools are graduating students understanding importance EHRs collaborative skills necessary to practice effectively team-based environment.Simulation education has shown promise for addressing these deficiencies.Objective: The specific objective study included application evaluation cognitive task...
Kidney formation proceeds in reptiles, birds, and mammals through the sequential development of pronopheros, mesonephros, finally metanephros. Metanephric nephron formation, termed nephrogenesis, ceases around birth is completely absent adults. We investigated presence adult nephrogenesis reptiles by examining kidneys from several species including T. scripta, C. picta, B. constrictor, tegu, A. carolinensis, mississipiensis. found that all major reptilian groups (Testudines, Archosauromorpha...
Acute kidney injury (AKI) is a common clinical problem with significant consequences on healthcare. It of great importance to understand the genetic and cellular changes induced by AKI. Stem cell antigen‐1 (Sca‐1, Ly6a), GPI‐anchored protein expressed progenitor as well differentiated populations. Although commonly used marker enrich for stem/progenitor cells, little known about function Sca‐1. Recent work has suggested Sca‐1 may play role in Smad activation downstream TGFβ receptor 1,...
The transcription factor Six2 plays a crucial role in maintaining self-renewing nephron progenitor cap mesenchyme (CM) during metanephric kidney development. In mouse and human, expression at single-cell resolution has detected cells as they leave the CM pool differentiate. may play these differentiate remains unknown. Here, we took advantage of zebrafish pronephric which forms directly from intermediate mesoderm to test six2b function tubule development differentiation. Expression early was...
Acute Kidney Injury (AKI) is a common medical condition with high mortality rate. With the repair abilities of kidney, it possible to restore adequate kidney function after supportive treatment. However, better understanding how nephron cell death and occur on cellular level required minimize enhance regenerative process. The zebrafish pronephros good model system accomplish this goal because contains anatomical segments that are similar mammalian nephron. Previously, most used study injury...