Purpose: The study establishes normative data of tear volume (TV) and turnover rate (TTR) in healthy dogs cats, 2 species commonly used for translational research ophthalmology. Methods: Thirty-six 24 cats were enrolled, encompassing a variety breeds with diverse skull conformations (brachycephalic, mesocephalic, dolichocephalic). Two microliters 10% fluorescein instilled onto the upper bulbar conjunctiva both eyes, followed by collection 2-μL capillary tubes at 0, 2, 4, 6, 10, 15, 20 min....

In this paper, we report a new power-free multifunctional soft contact lens device that can measure intraocular pressure (IOP), achieve extended drug delivery in situ, and detect glaucoma biomarkers, all within the same device. Experiments demonstrate sensor Interleukin 12p70, one possible biomarker for glaucoma, concentration as low 2 pg/ml artificial tears. The sustained release of last up to 30 days. ex vivo tests using cadaver pig eyes, detected IOP range 10-50 mmHg with excellent repeatability.

Because of the physiological and anatomical constraints eye, ophthalmic drug delivery is challenging. When applied topically, less than 1% administered drugs reach aqueous humor. The a within an efficient therapeutic concentration, to required site action, for extended period time, complicated. Herein, novel type contact lens device, with embedded microtubes as containers, reported. This device can provide simple, noninvasive, release up 45 days higher bioavailability lower risk adverse...

Abstract Objective To evaluate the visual outcome of three techniques corneal transplantation surgery in treating severe inflammatory keratopathies horse. Design Retrospective medical records study. Animals studied Medical 206 horses that received at University Florida Veterinary Center from 1993 to 2007 were reviewed. Procedure Data collected included signalment, types ocular lesions, type transplant performed, length follow‐up, complications, and outcomes. Results Full thickness...

To describe clinical findings in equine subepithelial keratomycosis (SEK).Retrospective medical records study.Medical of horses that had (SEK) at the University Florida Veterinary Medical Center from 2007 to 2011 were reviewed.Data collected included signalment, descriptions ocular lesions, diagnostic techniques, and therapeutic outcomes.Twenty-one horses, consisting three Quarter horse geldings, two Morgan one mare, Arabian mares, warm blood Thoroughbred Appaloosa Holsteiner gelding, mare...

Abstract Purpose To evaluate the IOP values obtained from normal canine eyes, by means of TonoVet Plus (TVP) and TonoPen Avia (TPA), compare them to an established tonometer, (TV). Methods Tonometry was performed bilaterally in 50 healthy dogs, age 1‐11 years. The rebound tonometers (TV TVP) were used first (in a random order), then, one drop tetracaine hydrochloride applied each eye, approximately minute later estimated using TPA. mean ± standard deviation (SD) calculated for tonometer...

To describe the clinical application and effect of MicroPulse™ transscleral cyclophotocoagulation (MP-TSCPC) in dogs with glaucoma.Twelve primary (n = 8) or secondary 4) glaucoma, aged 2-13 years (mean ± SD, 7.2 3.8 years).MP-TSCPC was performed under sedation general anesthesia. Laser duty cycle 31.3%, laser power varied from 2000-2800 mW, each hemisphere treated for 90-180 seconds. The probe applied to quadrant a "sweeping motion," sparing 3 9 o'clock positions.The number MP-TSCPC...

Abstract Background and Objectives To determine the threshold for electrophysiological detection of functional changes after laser photocoagulation in rats, to correlate damage with retinal morphology. Study Design/Materials Methods Argon‐laser lesions, covering a quarter or half retina, were produced right eyes 25 rats. Eyes evaluated by flash electroretinography (ERG) histologically at 3, 21, 60 days lasering. Results Lasering but not quarter, significant decrease signals all time points....

A 10-year-old, spayed female Bichon Frise was referred to the Veterinary Medical Center of University Florida with a 6-week history blepharospasm and nonhealing ulcer left eye. Ophthalmic examination revealed 3-4 mm diameter corneal faint edema at lesion edge, raised grayish area on paraxial cornea near 2 o'clock position. Cytological testing fungal hyphae extracellular cocci. Culture found heavy growth Enterococcus faecalis Curvularia spp. Treatment combination topical antibiotics...

To describe Schirmer tear test I and rebound tonometry findings in healthy bovine calves.Thirty-three clinically normal dairy breed calves of mean (SD) 11 (1.1) weeks (range, 9.3-13.3 weeks) age were evaluated.A was performed on each eye followed by tonometry, using a TonoVet(®) without topical anesthesia. We report means statistical analysis data for assay.For both (STT) significant differences not found between fellow eyes (P = 0.1536 P 0.83, respectively). The STT value all 20.4 (5.0)...

Abstract Objective To describe cases of suspected anticoagulant rodenticide toxicity manifesting with predominantly ocular signs. Materials and methods Six canine that presented to veterinary referral hospitals for abnormalities were diagnosed or confirmed ingestion reviewed commonalities in presentation outcome. Results Five dogs had unilateral signs one dog bilateral manifestations. Signs included subconjunctival hemorrhage, exophthalmos, commonly orbital pain without other significant...

Summary Reasons for performing study We wanted to investigate the visual outcome of horses presented with iris prolapse and treated corneal transplantation. Objective To evaluate penetrating keratoplasty alone in combination overlying conjunctival or amniotic membrane grafting. Methods A retrospective medical records University Florida Veterinary Medical Center period 1998‐2010. Data collected from included signalment, clinical descriptions ocular lesions, treatments, therapeutic outcome....

Abstract Objective The goal of this work is to study the dark adaptation curve normal horse electroretinogram (ERG). Procedures electroretinographic responses were recorded from six healthy female ponies using a contact lens electrode and mini‐Ganzfeld unit. horses sedated intravenously with detomidine, an auriculopalpebral nerve block was then performed, pupil fully dilated. ERG in response low intensity light stimulus (30 mcd.s/m 2 ) that given at times ( T = 5, 10, 15, 20, 25, 30, 40, 50,...

A free-ranging gopher tortoise (Gopherus polyphemus) presented for trauma and blindness. Fibrinous exudate obscured visualization of the globes. This exudative crust extended from conjunctival fornices through palpebral fissure was manually removed. Ophthalmic examination revealed bilateral corneal ulcerations scarring phthisis bulbi left globe. Histology a necrotic conjunctivitis with intralesional fungal hyphae. Culture ulcer eye isolated moderate growth mixed flora consisting Curvularia...

To evaluate the impact of extensive bullet-hole nontapetal fundic lesions in horses on retinal function as measured by full-field electroretinography (ERG).Full-field ERG was performed two with numerous fundus both eyes. The first recorded from eye more response to a low-intensity light stimulus (0.03 cd s/m(2) ) that given at times (T) T = 5, 10, 15, 20 min dark adaptation. Consecutively, combined rod-cone evaluated bilaterally high-intensity (3 ), followed cone evaluation flicker 30 Hz)....

A 4 yr old intact male rat terrier presented with severe bilateral nonresponsive panuveitis. Bilateral uveitis, blepharospasm, conjunctival hyperemia, diffuse corneal edema, peripheral bullous retinal detachment, and secondary ocular hypertension were noted. Ocular lesions progressed despite aggressive medical treatment followed by cutaneous depigmentation crusting along the nasal planum. Intensive oral topical anti-inflammatory antiglaucoma medications administered, but disease progressed....

To compare Schirmer tear test I (STT I) values obtained from placement of strips in the ventral and dorsal conjunctival fornices dogs.

The retina of some avian species contains two macular regions, making it an excellent model for retinal, and especially macular, development. Previous studies have provided evidence the involvement Pax6 in purpose was to perform a comprehensive expression analysis isoforms different regions pigeon retina.The mRNA transcripts were amplified by RT-PCR characterized sequencing analysis. Semiquantitative PCR quantitative real-time analyses used study level each transcript. Western blot performed...

Abstract OBJECTIVE To determine whether 2- or 3-times-daily application of topical ophthalmic 0.005% latanoprost solution is more effective at lowering intraocular pressure (IOP) in clinically normal dogs. ANIMALS 9 PROCEDURES For each dog, I drop was applied to 1 eye every 8 12 hours day for 5 days; the contralateral received treatment with saline (0.9% NaCl) times application. Ocular examinations both eyes were performed 6 starting 48 prior and ending 42 after period. Following a 5-week...

An 11-year-old Oldenburg mare presented following three episodes of acute, transient blindness, ataxia, and disorientation within the preceding 7 months. Clinical improvement, including return vision, occurred 1 week initiating corticosteroid therapy for each episodes. However, mild right-sided miosis was a consistent finding on ophthalmic examinations. Routine clinicopathologic testing revealed no significant abnormalities, cerebral spinal fluid selected infectious diseases unrewarding....

To compare the effect of commercially available solution and compounded ointment formulations dorzolamide(2%)-timolol(0.5%) on intraocular pressure (IOP) normal horses.Eighteen clinically horses.A randomized, masked prospective design was used with horses divided into two equal groups. One eye each horse selected for topical ophthalmic treatment either 0.2 mL or g every 12 h 5 days. The contralateral in both groups untreated. Rebound tonometry performed 6 starting 2 days prior to ending...

Abstract Objective To describe the occurrence of hypokalemia, metabolic acidosis, and suspected renal tubular acidosis associated with administration topical ophthalmic carbonic anhydrase inhibitor (CAI) in a cat. Case Summary A 2‐year‐old, 5.3 kg, male, castrated, domestic short‐haired cat developed hyporexia 6 weeks after starting dorzolamide 2% therapy for treatment ocular hypertension. Two later, was evaluated severe weakness, cervical ventroflexion, anorexia. Plasma electrolyte...