Jörg Zimmermann
A5053729438- Genetic Associations and Epidemiology
- Computability, Logic, AI Algorithms
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Neural dynamics and brain function
- Algorithms and Data Compression
- COVID-19 and Mental Health
- Prostate Cancer Treatment and Research
- Logic, Reasoning, and Knowledge
- Complex Systems and Time Series Analysis
- Model Reduction and Neural Networks
- Advanced Radiotherapy Techniques
- Personality Traits and Psychology
- Prostate Cancer Diagnosis and Treatment
- Advanced MIMO Systems Optimization
- Bioinformatics and Genomic Networks
- Cognitive Abilities and Testing
- Advanced Multi-Objective Optimization Algorithms
- Anomaly Detection Techniques and Applications
- Schizophrenia research and treatment
- AI-based Problem Solving and Planning
- ICT Impact and Policies
- Tryptophan and brain disorders
Landwirtschaftskammer Niedersachsen
2017-2024
Koblenz University of Applied Sciences
2023
University of Bonn
2002-2021
SUNY Upstate Medical University
2021
Klinikum Bremen-Mitte
2013-2018
Praxis
2018
Bonn Aachen International Center for Information Technology
2016-2018
Medizinische Hochschule Hannover
2017
Czech Academy of Sciences, Institute of Computer Science
2013
University of Rostock
2011
Significance Early life stress (ELS) is an important risk factor for schizophrenia. Our study shows that ELS in mice increases the levels of histone-deacetylase (HDAC) 1 brain and blood. Although altered Hdac1 expression response to widespread, increased prefrontal cortex are responsible development schizophrenia-like phenotypes. In turn, administration HDAC inhibitor ameliorates ELS-induced We also show brains patients with schizophrenia blood from who suffered ELS, suggesting analysis...
Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports genome-wide polygenic score (GPS) for educational attainment (GPSEDU) can be used to explain variability in cognitive performance. We aimed identify different domains associated with GPSEDU transdiagnostic clinical cohort chronic patients known deficits. Bipolar from the PsyCourse (N = 730; 43% female) were used. Likewise, we tested whether GPSs (GPSSZ) disorder (GPSBD)...
In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical genomic evidence have challenged this Kraepelinian dichotomy. There only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design first results of the PsyCourse study ( N = 891 individuals at baseline), an ongoing transdiagnostic affective‐to‐psychotic continuum that combines deep phenotyping...
Humans differ in their ability to learn how control own brain activity by neurofeedback. However, neural mechanisms underlying these inter-individual differences, which may determine training success and associated cognitive enhancement, are not well-understood. Here, it is asked whether neurofeedback of frontal-midline (fm) theta, an oscillation related higher functions, could be predicted the morphology structures known critically involved fm-theta generation. Nineteen young, right-handed...
The present study explored anxious apprehension in panic disorder patients and controls two threat conditions, darkness of shock. Autonomic arousal startle eyeblink reflexes were recorded 26 22 during adaptation, a safe condition, shock, darkness. Exposure to resulted clear potentiation the reflex. Panic but not responded with an increase heart rate that was positively related severity agoraphobic avoidance. Threat shock tended be stronger without comorbid depression than attenuated those...
Abstract As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing probabilistic susceptibility developing a disorder could guide mitigation measures and intervention. In this context, polygenic risk scores (PRSs) quantifying additive effects multiple common genetic variants hold potential predict complex diseases index severity gradients. PRSs for schizophrenia (SZ) bipolar (BD) were computed using Bayesian regression continuous...
Abstract Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of affective-to-psychotic spectrum controls, we investigated genetic basis time course two core executive subfunctions: set-shifting (Trail Making Test, part B (TMT-B)) updating (Verbal Digit Span backwards) in 1338 genotyped individuals. Time was assessed with four measurement points, each 6 months apart. Compared to initial...
Stressful life events influence the course of affective disorders, however, mechanisms by which they bring about phenotypic change are not entirely known.We explored role DNA methylation in response to recent stressful a cohort bipolar patients from longitudinal PsyCourse study (n = 96). Peripheral blood methylomes were profiled at two time points for over 850,000 sites. The association between impact ratings and was assessed, first interrogating sites vicinity candidate genes previously...
As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature mediating factors is unclear. Therefore, we investigated how ELS, education, symptom burden are related performance. The sample comprised 215 (age, 42.9 ± 12.0 years; 66.0 % male) 197 controls 38.5 16.4 39.3 from PsyCourse Study. ELS was assessed Childhood Trauma...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Zimmermann J, Osieka R, Bruns T, et al. Five-year effectiveness of low-dose-rate brachytherapy: comparisons with nomogram predictions in patients non-metastatic prostate cancer presenting significant control intra- and periprostatic disease. Journal Contemporary Brachytherapy. 2018;10(4):297-305. doi:10.5114/jcb.2018.77949. APA Zimmermann, J., Osieka, R., Bruns, T., Hollberg, H., Wiechmann, B., & Netzbandt, O....
We investigate stochastic local search by Markov chain analysis in a high and low dimensional discrete space. In the n-dimensional space B/sup n/ function called Jump is considered. The shows that an algorithm using large neighborhood never accepting worse points performs much better than any with certain probability. also functions many optima. compare neighborhoods optimal temperature schedules which depend on state of process.
We propose a simple 3-parameter model that provides very good fits for incidence curves of 18 common solid cancers even when variations due to different locations, races, or periods are taken into account. From data perspective, we use selection (Akaike information criterion) show this model, which is based on the Weibull distribution, outperforms other models like Gamma distribution. modeling distribution can be justified as accumulation driver events, establishes link stem cell division...
Various neural network based methods are capable of anticipating human body motions from data for a short period time. What these lack the interpretability and explainability its results. We propose to use Dynamic Mode Decomposition with delays represent anticipate motions. Exploring influence number on reconstruction prediction various motion classes, we show that anticipation errors in our results comparable or even better very times (<0.4 s) than recurrent method. perceive method as...
Biological systems and processes are highly dynamic. To gain insights into their functioning time-resolved measurements necessary. Time-resolved gene expression data captures temporal behaviour of the genes genome-wide under various biological conditions: in response to stimuli, during cell cycle, differentiation or developmental programs. Dissecting dynamic patterns from this may shed light on regulatory system. The present approach facilitates discovery. fundamental idea behind it is...