Rhiannon D. Grant
A5062142761- Microbial metabolism and enzyme function
- Chemotherapy-induced cardiotoxicity and mitigation
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Renal cell carcinoma treatment
Garvan Institute of Medical Research
2019-2023
The Kinghorn Cancer Centre
2021-2023
Abstract The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance this crosslinking and stabilizing fibrillar collagens its known role tumor desmoplasia. Using small-molecule drug-design approaches, we generated validated PXS-5505, first-in-class highly selective potent pan-lysyl inhibitor. We demonstrate vitro vivo that inhibition decreases chemotherapy-induced pancreatic desmoplasia stiffness, reduces cancer cell invasion metastasis,...
Abstract Background The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response cells to interventions normal disease situations. Unlike vivo settings, experiments allow fine‐tuned control range microenvironmental elements independently within an isolated setting. recent expansion three‐dimensional (3D) assays has created number representative tools study more physiologically 3D relevant microenvironment. Complex models that can...