Michael Tayao
A5059526917- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Retinal Development and Disorders
- Advanced Fluorescence Microscopy Techniques
- Caveolin-1 and cellular processes
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroendocrine Tumor Research Advances
- Microbial metabolism and enzyme function
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Phagocytosis and Immune Regulation
The Kinghorn Cancer Centre
2021-2025
Garvan Institute of Medical Research
2019-2025
UNSW Sydney
2021-2023
St Vincent's Clinic
2021-2023
Joyson Safety Systems (Japan)
2016
Gallagher (United States)
2016
St. Leonards Hospital
2016
University of Technology Sydney
2016
Keogh Institute for Medical Research
2016
Abstract The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance this crosslinking and stabilizing fibrillar collagens its known role tumor desmoplasia. Using small-molecule drug-design approaches, we generated validated PXS-5505, first-in-class highly selective potent pan-lysyl inhibitor. We demonstrate vitro vivo that inhibition decreases chemotherapy-induced pancreatic desmoplasia stiffness, reduces cancer cell invasion metastasis,...
Abstract In recent decades, the role of tumor biomechanics on cancer cell behavior at primary site has been increasingly appreciated. However, effect latter stages metastatic cascade, such as seeding secondary sites and outgrowth remains underappreciated. This work sought to address this in context triple negative breast (TNBC), a type known aggressively disseminate all disease progression. Using mechanically tuneable model systems, mimicking range stiffness's typically found within tumors,...
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that functions as tumor suppressor gene. Double hit BAP1 inactivation has been reported in range of types, including intrahepatic cholangiocarcinoma (ICC), sometimes association with germline mutation.We performed immunohistochemistry for on well-characterized cohort 211 ICC patients undergoing surgical resection curative intent at 3 institutions based different countries. The median age diagnosis was 65 years (range, 36.5-86)...
Intravital imaging guides a personalized medicine approach to target mechanoreciprocity in pancreatic cancer.
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis range types, but yet be explored. We show that expression NPY and NPY1R are up-regulated mouse models human PC. Moreover, using the genetically engineered, autochthonous KP R172H C model PC, we...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome highly metastatic KPC (
Background Pancreatic cancer is both common and highly lethal therefore new biomarkers or potential targets for treatment are needed. Loss of BRCA associated protein-1 (BAP1) expression has been found in up to a quarter intrahepatic cholangiocarcinomas. Given the close anatomical relationship between cholangiocarcinoma pancreatic ductal adenocarcinoma, we sought investigate frequency loss BAP1 adenocarcinoma. Methods The records department Anatomical Pathology Royal North Shore Hospital,...
Abstract Background The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response cells to interventions normal disease situations. Unlike vivo settings, experiments allow fine‐tuned control range microenvironmental elements independently within an isolated setting. recent expansion three‐dimensional (3D) assays has created number representative tools study more physiologically 3D relevant microenvironment. Complex models that can...
<p>Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Forster resonance energy transfer (FRET) biosensor mouse coupled in vivo photoswitching track intratumoral movement, we help guide treatment scheduling breast cancer setting impair metastatic progression. We uncover altered Rac1 activity at the center versus invasive border tumors...
<p>Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Forster resonance energy transfer (FRET) biosensor mouse coupled in vivo photoswitching track intratumoral movement, we help guide treatment scheduling breast cancer setting impair metastatic progression. We uncover altered Rac1 activity at the center versus invasive border tumors...