Young-Kyung Lee
A5005786768- Cholangiocarcinoma and Gallbladder Cancer Studies
- Caveolin-1 and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Bacteriophages and microbial interactions
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
Garvan Institute of Medical Research
2023-2024
The Kinghorn Cancer Centre
2023-2024
The University of Adelaide
2023
Synthetic biology has developed sophisticated cellular biosensors to detect and respond human disease. However, have not yet been engineered specific extracellular DNA sequences mutations. Here, we naturally competent Acinetobacter baylyi donor from the genomes of colorectal cancer (CRC) cells, organoids, tumors. We characterized functionality in vitro with coculture assays then validated them vivo sensor bacteria delivered mice harboring observed horizontal gene transfer tumor our mouse...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome highly metastatic KPC (
Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment many diseases. To monitor spatial temporal activity live setting, we generated Akt-FRET biosensor mouse that allows longitudinal assessment using intravital imaging conjunction with image stabilization optical window technology. We demonstrate sensitivity various cancer models verify its suitability to response drug targeting spheroid organotypic...