A5027152393- Plant Reproductive Biology
- Plant Molecular Biology Research
- Advanced Electron Microscopy Techniques and Applications
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Electron and X-Ray Spectroscopy Techniques
- Polysaccharides and Plant Cell Walls
- Distributed Sensor Networks and Detection Algorithms
- Catalytic Processes in Materials Science
- Photosynthetic Processes and Mechanisms
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Research in Cotton Cultivation
- Microtubule and mitosis dynamics
- Supramolecular Self-Assembly in Materials
- Intelligent Tutoring Systems and Adaptive Learning
- Helicobacter pylori-related gastroenterology studies
- Tree Root and Stability Studies
- Infections and bacterial resistance
- Distributed Control Multi-Agent Systems
- Cancer-related molecular mechanisms research
- Ideological and Political Education
- Biopolymer Synthesis and Applications
- Antibiotic Resistance in Bacteria
- Growth Hormone and Insulin-like Growth Factors
Nanjing University of Science and Technology
2024-2025
Capital University
2024
Peking University
2019-2023
Nankai University
2022-2023
Zunyi Medical University
2022
Beijing Computing Center
2022
WuXi AppTec (China)
2020
Chinese Academy of Sciences
2014-2019
State Key Laboratory of Plant Genomics
2014-2019
University of Chinese Academy of Sciences
2014-2019
Microtubules (MTs) and actin filaments (F-actin) function cooperatively to regulate plant cell morphogenesis. However, the mechanisms underlying crosstalk between these two cytoskeletal systems, particularly in shape control, remain largely unknown. In this study, we show that introduction of MyTH4-FERM tandem into KCBP (kinesin-like calmodulin-binding protein) during evolution conferred novel functions. The MyTH4 domain FERM N-terminal tail physically bind MTs F-actin, respectively. During...
The cellular functions are executed by biological macromolecular complexes in nonequilibrium dynamic processes, which exhibit a vast diversity of conformational states. Solving the continuum important biomolecular at atomic level is essential to understanding their functional mechanisms and guiding structure-based drug discovery. Here, we introduce deep manifold learning framework, named AlphaCryo4D, enables atomic-level cryogenic electron microscopy (cryo-EM) reconstructions that...
This article investigates the security problem of distributed state estimation for nonlinear systems subject to stealthy attacks and limited energy. First, a novel detection strategy information consensus filter is designed resist adversary which can modify data transmitted through wireless network. Unlike existing attack strategies, proposed defense capable simultaneously verifying authenticity received local estimate error covariance. Afterward, considering communication resources, an...
Fibre cell initiation and elongation is critical for cotton fibre development. However, little known about the regulation of during Here, regulatory role a novel protein GhCFE1A was uncovered. preferentially expressed at rapid stages development; in addition, much higher expression detected stage fibreless mutants than fibre-bearing TM-1 wild-type. Importantly, overexpression not only delayed but also significantly reduced density lint fuzz initials stem trichomes. Yeast two-hybrid assay...
Course recommendation aims at finding proper and attractive courses from massive candidates for students based on their needs, it plays a significant role in the curricula-variable system. However, nearly all nowadays need help selecting appropriate abundant ones. The emergence application of personalized course recommendations can release that cognitive overload problem. still needs to mature improve its scalability, sparsity, cold start problems resulting poor quality recommendations....
Summary The 26S proteasome regulates proteostasis and myriad cellular processes. Here we reconstitute the hidden dynamics of human during protein degradation using cryo-EM data-driven deep learning, which identified 64 proteasomal conformers. These conformers revealed substrate-dependent conformational entanglement two 19S regulatory particles in doubly capped holocomplexes. rate-limiting step single-nucleotide exchange AAA-ATPase motor is ATPase re-engagement with substrate, while...
Abstract The cellular functions are executed by biological macromolecular complexes in nonequilibrium dynamic processes, which exhibit a vast diversity of conformational states. Solving continuum important biomolecular at atomic level is essential to understand their functional mechanisms and guide structure-based drug discovery. Here we introduce deep learning framework, named AlphaCryo4D, enables atomic-level cryogenic electron microscopy reconstructions continuum. AlphaCryo4D integrates...
ABSTRACT Proteus mirabilis , a significant pathogenic bacterium within the Enterobacteriaceae family, is widely distributed across various natural environments. This study conducted genomic comparison analysis of 1,267 strains P. using extensive genome data from public databases. The objective was to elucidate pan-genomic structure revealing composition and distribution core accessory gene families among different strains. Additionally, an attempt made construct multilocus sequence typing...
The 2.5-MDa 26S proteasome maintains proteostasis and regulates myriad cellular processes. How polyubiquitylated substrate interactions regulate activity is not understood. Here we introduce a deep manifold learning framework, named AlphaCryo4D, which enables atomic-level cryogenic electron microscopy (cryo-EM) reconstructions of nonequilibrium conformational continuum reconstitutes hidden dynamics autoregulation in the act degradation. AlphaCryo4D integrates 3D residual with embedding...
By using the periodic density functional theory (DFT) method, adsorption and activation of CO on clean potassium-modified transition metals, which includes Fe(100), Co(0001), Ni(111)/(100), Cu(111), Ru(0001), Rh(111)/(100), Pd(111), Pt(111) surfaces, have been investigated systematically. The calculation results show that additive potassium atoms greatly enhances binding strength O while only slightly improving C atoms. Moreover, energy dissociation is decreased in presence Our indicate...
Abstract Ryanodine receptors (RyRs) are Ca 2+ -regulated channels of 2.2-megadalton in muscles and neurons for calcium signaling. How regulates ion conduction the RyR remains elusive. We determined a 2.6-Å cryo-EM structure rabbit skeletal muscle RyR1, used multiscale dynamics simulations to elucidate cation interactions with RyR1. investigated 21 potential cation-binding sites that may together rationalize biphasic response The selectivity filter captures hydration complex by...
Ion-complementary self-assembling peptides have been studied in many fields for their distinct advantages mainly due to self-assembly properties. However, shortcomings, such as insufficient specific activity and poor mechanical properties, also limited application. For better wider application of this kind promising biomaterials, ion-complementary can be modified with properties not being destroyed the greatest extent. The modification strategies were reviewed by taking RADA16-Ⅰ an example....