A5039916479- Atmospheric chemistry and aerosols
- Trace Elements in Health
- Atmospheric Ozone and Climate
- Atmospheric aerosols and clouds
- Atmospheric and Environmental Gas Dynamics
- Heavy Metal Exposure and Toxicity
- Catalysis and Oxidation Reactions
- Ion channel regulation and function
- Coal and Its By-products
- Muscle Physiology and Disorders
- Air Quality and Health Impacts
- RNA Research and Splicing
- Catalytic Processes in Materials Science
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Thermography and Photoacoustic Techniques
- Odor and Emission Control Technologies
- Heavy metals in environment
- Spectroscopy and Laser Applications
- Photochemistry and Electron Transfer Studies
- Laser-induced spectroscopy and plasma
- TiO2 Photocatalysis and Solar Cells
- Aeolian processes and effects
- Porphyrin and Phthalocyanine Chemistry
- Chemical Thermodynamics and Molecular Structure
Skidmore College
2015-2024
Saratoga Hospital
2015
University of Iowa
2009-2011
Lawrence University
2010
Corning (United States)
2009
Baylor University
2005-2006
Central University of Venezuela
2001-2002
Petroleum of Venezuela (Venezuela)
2001
University of Tennessee at Knoxville
2001
Nitrous acid (HONO), a highly reactive trace atmospheric gas, is often underestimated in global models due to the poor understanding of its sources and sinks, especially marine boundary layer (MBL). Herein, we have investigated HONO formation from irradiation nitrate solutions presence increasingly complex photosensitizers including dissolved organic matter (m-DOM), which contains chromophoric matter, collected large-scale mesocosm experiment. In particular, aqueous m-DOM, humic (HA),...
Metal‐regulatory transcription factor 1 (MTF1) is a conserved metal‐binding in eukaryotes that binds to DNA sequence motifs, termed metal response elements. MTF1 responds both excess and deprivation, protects cells from oxidative hypoxic stresses, required for embryonic development vertebrates. To examine the role cell differentiation, we use multiple experimental strategies [including gene knockdown (KD) mediated by small hairpin RNA clustered regularly interspaced short palindromic...
In this study, CO2 adsorption in the presence and absence of co-adsorbed H2O was investigated zeolite Y. Several different Y materials were including commercial NaY, NaY ion-exchanged with Ba2+ nanocrystalline NaY; herein referred to as BaY nano-NaY. Following heating these zeolites 573 K cooling room temperature, adsorbed a function pressure. FTIR spectra show that majority adsorbs pores three (NaY, nano-NaY) linear complex exchangeable cation, indicated by intense absorption band near 2350...
Mineral dust aerosol is known to provide a reactive surface in the troposphere for heterogeneous chemistry occur. Certain components of mineral aerosol, such as semiconductor metal oxides, can act chromophores that initiate chemical reactions, while adsorbed organic and inorganic species may also be photoactive. However, relatively little about impact photochemistry atmosphere. In this study, we investigate trace atmospheric gases including HNO(3) O(3) with using an environmental chamber...
Nitrous acid (HONO) is a key molecule in the reactive nitrogen cycle. However, sources and sinks for HONO are not fully understood. Particulate nitrate photochemistry has been suggested to play role formation of marine boundary layer (MBL). Here we investigate impact relevant organic compounds on from aqueous photochemistry. In particular, steady-state, gas-phase yields were measured irradiated solutions at low pH containing marine-dissolved matter (m-DOM). m-DOM induces nonlinear increase...
Nitric acid, a well-known sink of NOx gases in the atmosphere, has been found to be photoactive while adsorbed on tropospheric particles. When onto semiconductive metal oxides, nitrate's photochemical degradation can interpreted as photocatalytic process. Yet, photolysis nitrate ions surface aerosols also initiated by changes symmetry ion upon adsorption. In this study, we use quantum chemistry model vibrational spectra TiO2, semiconductor component atmospheric aerosols, and determine...
The loading of copper (Cu) into cytochrome c oxidase (COX) in mitochondria is essential for energy production cells. Extensive studies have been performed to characterize mitochondrial cuproenzymes that contribute the metallation COX, such as Sco1, Sco2, and Cox17. However, limited information available on upstream mechanism Cu transport delivery mitochondria, especially through Cu-impermeable membranes, mammalian phosphate transporter SLC25A3, also known PiC2, binds Cu+ transports ion these...
Zinc (Zn) is an essential trace element that plays a key role in several biological processes, including transcription, signaling, and catalysis. A subcellular network of transporters ensures adequate distribution Zn to facilitate homeostasis. Among these are family importers, the Zrt/Irt-like proteins (ZIP), which consists 14 members (ZIP1-ZIP14) mobilize from extracellular domain organelles into cytosol. Expression varies among tissues during developmental stages, their at various cellular...
Atmospheric aerosols are known to provide an important surface for gas-solid interfaces that can lead heterogeneous reactions impacting tropospheric chemistry. In this work, α-Fe2O3, TiO2, γ-Al2O3, SiO2 and ZnO, common components of atmospheric aerosols, served as models investigate the interface nitric acid with in presence simulated solar radiation. Adsorbed nitrate gaseous products be continuously monitored infrared spectroscopy (IR). Kinetic studies adsorbed species were carried out...
In this study, horizontal attenuated total reflection (HATR) Fourier-transform infrared (FT-IR) spectroscopy was combined with quartz crystal microbalance (QCM) gravimetry to investigate the adsorption isotherms of water on fly ash, a byproduct coal combustion in power plants. Because composition variability source region, uptake studied at room temperature as function relative humidity (RH) ash from several regions: United States, India, The Netherlands, and Germany. FT-IR spectra show...
Zinc transporters facilitate metal mobilization and compartmentalization, playing a key role in cellular development. Little is known about the mechanisms pathways of Zn movement between metalloproteins during myoblast differentiation. We analyzed differential expression ZIP ZnT C2C12 account for transient decrease intracellular upon myogenesis induction followed by gradual increase myotubes. Considering subcellular localization function each transporters, our findings indicate that fine...
Atmospheric nitrous acid (HONO), a trace atmospheric gas, is often underestimated in global models due to the poor understanding of its daytime sources and sinks. HONO known accumulate during nighttime undergo rapid photodissociation day form NO highly reactive OH radical, making it important have accurate estimations. Despite photolysis, recent field observations found quasi-steady-state concentrations at midday, suggesting photolytic formation pathways replenish HONO. Recent studies...
Atmospheric combustion particles, such as fly ash emitted from coal-fired power plants, are a potential source of atmospheric iron, with significant implications in climate and global biogeochemical cycles. While the iron content speciation depend closely on region process, few studies have been carried out comparing processing produced plants different regions. In this study, we present an investigation dissolution acidic aqueous solutions: HNO3 HCl at pH 1 2 under daytime nighttime...
ABSTRACT Copper (Cu) is an essential trace element required for respiration, neurotransmitter synthesis, oxidative stress response, and transcriptional regulation. Imbalance in Cu homeostasis can lead to several pathological conditions, affecting neuronal, cognitive, muscular development. Mechanistically, Cu-binding proteins (Cu-BPs) have important but underappreciated role transcription regulation mammalian cells. In this context, our lab investigates the contributions of novel Cu-BPs...
Environmental context. Dust particles produced from wind blown soils are of global significance as these dust not only impact visibility, evident in the recent 2009 Australian storm, but also atmospheric chemistry, climate and biogeochemical cycles. The amount water vapour atmosphere (relative humidity) can play a role processes yet there few studies little quantitative data on water-dust particle interactions. focus this research is quantifying interactions for several sources including...
Environmental contextIron, a limiting nutrient of plankton in the ocean, is deposited to sea from atmospheric aerosols. In particular, acidic conditions promote dissolution iron fly ash, by-product coal-fired power plants. Here, we report that leached ash depends on its source region, and type combustion process may influence species mobilized. AbstractFly an iron-containing plants, has been observed aerosol plumes. Under resulting uptake gases, can impact global biogeochemical cycles....
Adhesion is a crucial characteristic of epithelial cells to form barriers pathogens and toxic substances from the environment. Epithelial attach each other using intercellular junctions on lateral membrane, including tight adherent junctions, as well Na+,K+-ATPase. Our group has shown that non-adherent chinese hamster ovary (CHO) transfected with canine β1 subunit become adhesive, those homotypic interactions amongst subunits Na+,K+-ATPase occur between neighboring cells. Ouabain,...
We have carried out kinetic and reaction yield studies to determine the effect of O(3) on heterogeneous two cyclic volatile methylsiloxanes (cVMS), octamethylcyclotetrasiloxane (D(4)) decamethylcyclopentasiloxane (D(5)), with model mineral dust aerosol in order obtain a better understanding atmospheric fate cVMS. The chemistry was studied an environmental chamber using FT-IR spectroscopy monitor progress. uptake kinetics extent for D(4) D(5) presence were quantified components aerosol,...
Transition metals are essential micronutrients for organisms but can be toxic to cells at high concentrations by competing with physiological in proteins and generating redox stress. Pathological conditions that lead metal depletion or accumulation causal agents of different human diseases. Some examples include anemia, acrodermatitis enteropathica, Wilson's Menkes' It is therefore important able measure the levels transport transition biological samples sensitivity accuracy order facilitate...
Organic chromophores initiate much of daytime aqueous phase chemistry in the environment.