A5081632497- Blood properties and coagulation
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemoglobin structure and function
- Cell death mechanisms and regulation
- Mast cells and histamine
- Cancer-related Molecular Pathways
- Angiogenesis and VEGF in Cancer
- Neonatal Health and Biochemistry
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral-associated cancers and disorders
- Phagocytosis and Immune Regulation
- Pressure Ulcer Prevention and Management
- Plant biochemistry and biosynthesis
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Clinical Laboratory Practices and Quality Control
Tel Aviv University
2012-2023
Rabin Medical Center
2011-2021
Clalit Health Services
2013-2014
Lenox Hill Hospital
2004
A large proportion of B‐chronic lymphocytic leukaemia (B‐CLL) cells express the anti‐apoptotic protein Bcl‐2. Basic fibroblast growth factor (bFGF) has been shown to upregulate expression Bcl‐2 in B‐CLL cell lines. Vascular endothelial (VEGF) enhance survival by upregulating In present study, we measured serum and cellular levels bFGF VEGF 85 patients with CLL using a commercial quantitative sandwich enzyme immunoassay technique. Levels were also assayed concomitantly Western blot analysis....
n -3 Fatty acids are recognised as influencing both wound healing and immunity. We assessed the impact of a fish oil- micronutrient-enriched formula (study formula) on pressure ulcers immune function in critically ill patients an intensive care unit. A total forty with receiving nutritional support were enrolled (intervention group, 20, received study formula; control isoenergetic formula). Total differential leucocyte count percentage adhesion molecule positive granulocyte lymphocyte cells...
Abstract: B‐Chronic lymphocytic leukemia (B‐CLL) is an example of a human malignancy caused by alterations in the pathways programmed cell death. In this disease anti‐apoptotic protein, bcl‐2, overexpressed and may lead to prolonged survival malignant CLL clone. present study we examined expression bcl‐2 bax, which has antagonistic role against function cells from patients at different stages disease, immunoblot analysis. A direct association between stage level patients' cell, was observed....
Background:To describe Rituximab associated neutropenia (RAN), and to explore its underlying mechanism.Case Report:We three patients with RAN. The effect of patient's plasma on colony forming unit, Granulocyte-Monocyte (CFU-GM) was measured by the addition culture a healthy bone-marrow. Repeated tests were performed after recovery white count.In leukopenic period inhibited CFU growth completely. Control did not have such an effect. Addition cell supernatant bone marrow cells change number...
It is now clear that angiogenesis and factors are important in the pathogenesis of haematological malignancies. High pretreatment levels serum basic fibroblast growth factor have been shown to be associated with poor prognosis patients non-Hodgkin's lymphoma. The aim this study was evaluate whether lymphoma cells express and/or its receptor (fibroblast receptor-1) expression correlates levels, intratumoral microvessel density, patient outcome. We measured by enzyme-linked immunosorbent assay...
It is unclear what minimal criteria will identify all new cases of acute leukemia in adults various settings.To determine the adult detection rate criteria, we recorded complete blood count (CBC) test results from consecutive patients with (130 hospitalized and 96 outpatients) without (34,827 33,695 outpatients).Basic for a reflex review (hemoglobin, platelets, five-part differential) detected 91% hospital (118 130) compared to 75% (72 96) outpatients. No were missed if did testing when...
Elevated counts of nucleated red blood cells (NRBCs), as well prolongation pregnancy, have been suggested predictors adverse perinatal outcome. However, the association between these 2 variables has received only minimal attention. We sought to evaluate fetal NRBCs in prolonged pregnancies.Umbilical cord was prospectively collected at delivery from 75 (at or beyond 287 days) pregnancies. One hundred and fifty term deliveries (260-286 served controls. All pregnancies were accurately dated...
Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold test for PFD is platelet aggregation, performed light transmission aggregometry (LTA). A newer and less validated method the closure time (CT), Analyzer 100 (PFA-100). Data regarding validity these tests in children limited. aim this study was to evaluate usefulness LTA PFA-100 diagnosis pediatric patients with This retrospective included...
B-chronic lymphocytic leukemia (B-CLL) is a disease caused primarily by defects in the apoptosis mechanism. AN-9, butyric acid (BA) derivative, potent differentiating and an anti-cancer drug that induces HL-60 cells. Herein we show affect of alone combination with doxorubicin, on cell cultures from B-CLL patients. Cells 17 patients were cultured tested for viability, apoptosis, bcl-2 bax protein expression. Exposure to AN-9 was accompanied marked viability loss (up 46%, p=0.0017). reduced up...
The availability of historical data decreases the rate blood smear review rates in outpatients, but we are unaware studies done at referral centres. In following study, determined effect on peripheral smears over a 3-month period and then detection patients with acute leukaemia.All results complete counts (CBCs) tested three ADVIA 120 analyzers regional Rabin Medical Centre, Beilinson Campus were accessed computerised laboratory information system. Over period, proportion total CBC criteria...
A study of the effects three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation differentiation primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA an effective inhibitor cell inducer cytodifferentiation. An acute non-lymphoblastic leukemia patient treated sodium butyrate. temporary increase in differentiation-associated parameters were noted. However, SB short-lived. lack...
Hereditary thrombocythaemia (HT) is an inherited autosomal dominant disorder. Recent studies reported six different mutations, four within the thrombopoietin (TPO) gene and two c-Mpl (TPO receptor) in unrelated families with HT. This study investigated molecular basis of hereditary Israeli-Jewish family. We screened genes for TPO by amplification sequencing all corresponding exons including exon/intron boundaries promoters. In addition, plasma levels erythropoietin (EPO) were measured. No...