A5103709307- RNA and protein synthesis mechanisms
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
Centre de Recherche en Cancérologie de Lyon
2016-2025
Centro de Investigación del Cáncer
2025
Cancer Research Center
2025
Hospices Civils de Lyon
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Inserm
2016-2024
Université Claude Bernard Lyon 1
2016-2024
Laboratoire CarMeN
2021-2024
Centre National de la Recherche Scientifique
2016-2022
Centre Léon Bérard
2016-2022
Research Article5 September 2016Open Access Source DataTransparent process ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors Geoffrey Richard Cancer Center of Lyon, INSERM U1052, France CNRS UMR 5286, Université de ISPB, Lyon 1, Centre Léon Bérard, Search for more papers by this author Stéphane Dalle Dermatology Unit, Hospices Civils CH Sud, Pierre Bénite Cedex, Marie-Ambre Monet Maud Ligier Amélie Boespflug Roxane M Pommier Arnaud la Fouchardière Department...
Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. While prescribed as an inhibitor DNA replication, 5-FU alters all RNA pathways. Here, we show that treatment leads production fluorinated ribosomes exhibiting altered translational activities. incorporated into ribosomal RNAs mature cancer cell lines, colorectal xenografts,...
Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes to treat due lack effective therapeutic options. Ribosome biogenesis has recently emerged as a promising target across various cancers. Despite current targeting ribosome through RNA polymerase I (RNA Pol I) inhibition, we speculated that other factors essential for assembly, such rRNA maturation factors, may also represent targets in TNBC. Here, demonstrate biogenesis-related genes are notably overexpressed...
Abstract Background Neuroblastoma is a heterogeneous malignant paediatric tumor with prognosis depending on patient age and disease stage. Current treatment strategies rely four key diagnostic criteria: age, histological stage, MYCN gene status, genomic profile. It has been reported that MYC oncogenic activity depends ribosome biogenesis, whose hyperactivation in cancer cells supports their high proliferative capacity, thus represent potential therapeutic target. Methods we utilized the...
Abstract Obesity is associated with both chronic and acute respiratory illnesses, such as asthma, obstructive pulmonary disease (COPD) or increased susceptibility to infectious diseases. Anatomical but also systemic local metabolic alterations are proposed contributors the pathophysiology of lung diseases in context obesity. To bring perspective this discussion, we used NMR compare obesity-associated metabolomic profiles those liver, heart, skeletal muscles, kidneys, brain serum from male...
Obesity is a risk factor for many diseases, such as type 2 diabetes and cardiovascular diseases. In line with the need precision medicine, search biomarkers reporting progression of obesity- diet-associated disorders urgent. We used NMR to determine metabolomics profile key organs (lung, liver, heart, skeletal muscle, kidney, brain) serum from male C57Bl/6J mice (5 weeks old) fed 6, 10, 14 on high-fat high-sucrose diet (HFHSD) vs. standard (STD). determined metabolite concentrations in at...