A5091815085- Virus-based gene therapy research
- Crystallization and Solubility Studies
- Animal Virus Infections Studies
- X-ray Diffraction in Crystallography
- Animal Disease Management and Epidemiology
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Luminescence and Fluorescent Materials
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Crystallography and molecular interactions
- RNA regulation and disease
- Mosquito-borne diseases and control
- Protein Structure and Dynamics
- Color perception and design
- Click Chemistry and Applications
- RNA Research and Splicing
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Biosensors and Analytical Detection
- Redox biology and oxidative stress
Peter Doherty Institute
2022-2024
The University of Melbourne
2022-2024
La Trobe University
2019-2022
Chengdu Technological University
2021
South China Agricultural University
2014-2016
Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general method of using the fluorogenic probe NTPAN-MI reported quantify subcellular change in response protein unfolding. fluorescence selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on extent proteostasis. also reveals collapse host proteome caused by influenza A virus infection. The emission profile contains information local...
A growing number of studies have demonstrated that both macroautophagy/autophagy and apoptosis are important inner mechanisms cell to maintain homeostasis participate in the host response pathogens. We previously reported a functional autophagy pathway is trigged by infection classical swine fever virus (CSFV) required for viral replication release cells. However, interplay CSFV-infected cells has not been clarified. In present study, we induction with rapamycin facilitates cellular...
Abstract Bacterial synthesis of vitamin B2 generates a by‐product, 5‐(2‐oxopropylideneamino)‐ d ‐ribityl‐aminouracil (5‐OP‐RU), with potent immunological properties in mammals, but it is rapidly degraded water. This natural product covalently bonds to the key protein MR1 endoplasmic reticulum antigen presenting cells (APCs), enabling refolding and trafficking cell surface, where interacts T receptors (TCRs) on mucosal associated invariant lymphocytes (MAIT cells), activating their...
Abstract Memory regulatory T cells (mTregs) have been demonstrated to persist long‐term in hosts after the resolution of primary influenza A virus (IAV) infection. However, whether such IAV infection‐experienced (IAV‐experienced) mTregs differentiate into a phenotypically and functionally distinct Treg subset what function they play at infection site remains poorly defined. In this study, we characterized phenotype, examined responsiveness assessed suppressive IAV‐experienced memory Tregs...
MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B–related metabolite antigens from diverse microbes and presents them at the cell surface to stimulate MR1-restricted lymphocytes including mucosal-associated invariant T (MAIT) cells. presentation MAIT recognition mediate homeostasis through host defense tissue repair. The cellular mechanisms regulating expression are critical its function recognition, yet they poorly defined. Here, we report that...
Abstract Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general method of using the fluorogenic probe NTPAN‐MI reported quantify subcellular change in response protein unfolding. fluorescence selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on extent proteostasis. also reveals collapse host proteome caused by influenza A virus infection. The emission profile contains...
Abstract Bacterial synthesis of vitamin B2 generates a by‐product, 5‐(2‐oxopropylideneamino)‐ d ‐ribityl‐aminouracil (5‐OP‐RU), with potent immunological properties in mammals, but it is rapidly degraded water. This natural product covalently bonds to the key protein MR1 endoplasmic reticulum antigen presenting cells (APCs), enabling refolding and trafficking cell surface, where interacts T receptors (TCRs) on mucosal associated invariant lymphocytes (MAIT cells), activating their...
CD4+ T cells recognize peptides presented by major histocompatibility complex class II molecules (MHC-II). These are generally derived from exogenous antigens. Macroautophagy has been reported to promote endogenous antigen presentation in viral infections. However, whether influenza A virus (IAV) infection-induced macroautophagy also leads through MHC-II is still debated. In this study, we show that IAV infection of an immunodominant epitope NP311-325 cells. Mechanistically, such...
The innovative design strategy of intelligent infusion set was studied from the perspective user needs. Firstly, experience map is used to analyze user's behavior process, emotional process and thinking during infusion, so as find opportunities sort out Then KANO model needs classify quantitative attributes each need. Then, Better-Worse index calculated according frequency statistics, key points are summarized results, output. This method can help determine opportunity product innovation...